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slackboxed
21-02-2008, 08:08
Recently, SWIM ate about 200mgs of (pure powdered) alprazolam one night, drank with it, and then four days later she ate about 20 gel tab hits of lsd and while she was tripping she ate around 500mgs of alprazolam all at once. She is prescribed benzos so she had a little bit of a tolerance, but holy shit I have never seen anyone so fucked up on benzos before in my entire life! She actually drank beer an hour into it. I read up on erowid that it takes about ~330mgs-2000mgs to kill lab rats with alprazolam.

How much alprazolam do you think it would take to kill a 120lb girl with a slight benzo tolerance (she is prescribed 5mg valiums 4x a day)? We're talking some pure powder here, supposidely 98-99% pure unadulterated but who the hell knows now a days ya know?

Oh the dumbass girl is alright. No serious injuries occured somehow.

drew345
21-02-2008, 08:11
wow 500mg and slight tolerance just dont really go together. I say either way you should tell her shes gonna die. if she fucks up and mixes alcohal or opiates, in to big a dose she is done for.

burn out
21-02-2008, 08:20
why is this person eating so much alrazolam powder? that's the question that should be addressed.

Ham-milton
21-02-2008, 08:34
Well, just Alprazolam, no alcohol or opiates (especially no opiates), and she'll be fine, but that's a horrible road to start going down.

BlueEclipse
21-02-2008, 08:36
wow if your having to take that much you need to lay off. esp if u said she has lil tolerance. As far as i kno and correct me if im wrong it takes alot to overdose and dieing on alprazolam but once u have a high tolerance for it and trying to quit suddenly can cause you to have many problems and possible die. IE start having sezuires and other things.

burn out
21-02-2008, 08:44
Well, just Alprazolam, no alcohol or opiates (especially no opiates), and she'll be fine, but that's a horrible road to start going down.

i can't believe people are saying she'll be fine. 500 mgs of alprazolam to someone with almost no benzo tolerance? i know it's ridiculously hard to overdose on benzos alone but the LD50s have never been tested on humans, not to mention what kind of affects this type of overdose could have on the nervous system.

slackboxed
21-02-2008, 08:45
It's not like we can taper her off, she just ate all of the fucking alprazolam. If she develops a super-tolerance from this, she's fucked because she actually does have panic disorders. Is there a step up on the benzo chain or any way to taper her off this shit with out having any more alprazolam? She is still prescribed valium.

willow11
21-02-2008, 08:49
^Valium is the best for tapering....long half life. If neccesary she should ask to get her dose bumped up for a week or two and then back down to 20mg a day.

burn out
21-02-2008, 08:49
i don't think she would need to taper from only 2 doses no matter how high they were . there will be so much alprazolam in her system that despite it's short half life, it will be as if she is doing a very fast taper and the valium should prevent any seizures. all she has to worry about is the short term affects of ingesting 1,000 times the initial dose of alprazolam at once. if she feels fine now, she should be fine. but taking these ridiculous amounts of benzos when you have little tolerance is not safe and just because she is fine doesn't mean other people can assume its safe to take that much.

'medicine cabinet'
21-02-2008, 09:06
that sounds absolutely horrible...talk about black out city. im surprised nothign more serious happened to her all things considered. i guess when you take 20 gel tabs your sense of reasoning goes out the window.

smokester
21-02-2008, 09:19
Your (or her/SWIYrs) best bet would be clonazepam for the quick taper after this binge (as opposed to long term addiction at does that high) back to a therapeutic dosage of her valium if preferable.

Clonazepam:

a)has a high therapeutic index, being a potent benzo anticonvulsant (something she needs more than anything) and anxiolytic (root of problem)

b)reasonable intermediate half-life (so she wouldnt actually be accumulating the drug and cheating tapering, actually fueling high-tolerance addiction considering it was a short alprazolam (xanax) binge, while easing intensity of the WDs)

Ham-milton
21-02-2008, 10:00
i can't believe people are saying she'll be fine. 500 mgs of alprazolam to someone with almost no benzo tolerance? i know it's ridiculously hard to overdose on benzos alone but the LD50s have never been tested on humans, not to mention what kind of affects this type of overdose could have on the nervous system.

500mg barely even begins to approach the danger zone. We're talking at least 1g/kg. I cannot find an overdose resulting in death from alprazolam without another depressant added to the mix.

Alprazolam, and benzos in general, are fairly selective BZR agonists. Because they work in a way that's very different than Barbs and other "old" depressants.

How long has she been using it? If it's been a fairly short period of time, withdrawal won't be a big concern. You can take 500mg two days in a row and be fine afterwards, though you'll certainly feel like shit, it's not really a big worry.

When I last looked into it, you cannot use Diazepam to taper from Alprazolam. I assume it's because of differences in binding profiles and not the ultra-short halflife issue. By using Diazepam in conjunction with a alprazolam taper, you could get off the xanax a lot easier and then afterwards taper off of diazepam which should be comparatively easier.

However, I can't reccomend ANYONE to taper from benzos or any other classical depressant (Barbs, Benzos, Methyprylon, Glutethimide). It's simply too dangerous and can easily fuck you up for the rest of your life.

If you have anything but a very weak dependence (and you're getting them from a legit source), you should seriously consider staying on them for the rest of your life. Even if you became dependent through extra-medical sources, you really ought to see a doctor. They can help you taper off safely, and if it does prove to be too painful (I can't imagine the 24/7 panic attacks and the twitching and the pain, etc), they can work out a careful regiment to keep you on the drug for the rest of your life. They won't do so lightly, but if you really can't taper, most doctors realize the neccessity of keeping benzo-dependent people on them forever.

Valium
21-02-2008, 10:27
poor girl...

probably payed a shiessload of money for that giant bag of 'pure unadulterated' powdered sugar.....

you have to be careful when you buy. it's not even necessary to buy, but i won't get into that here, since the forum restrictions forbid me from engaging in such activity.


i will preach for a minute, may i?

I am an EXTREMELY like in bold and caps locks and italics and underlined giant red gothic letters dripping with blood form of EXTREMELY experienced benzo user. I say this not to boast or establish my status here for people whom I don't even know anyway..what would it give me?

Im just saying....even with my tolerance, specialty being xanax, if i took 200mg one day and then got smashed and then the hypothetical next day, which would happen in the magical supposition that I made it through the night, intubated in the ICU at Lenox Hill (as I have so many nights before, thank you doctors of lenox hill. **blows air kisses and dollar bills**), and then took 500 forking milligrams of the same xanax and then walked around sipping a beer.......

i mean is this supposed to be funny? its not. its absurd. its bad humor. waiting for godozepam... i swear to god.

i hope no one believes that this is possible. after about 25-60 mg, most EXPERIENCED users (i mean the same ones that write EXPERIENCED on their Armani Le Collezioni suits in blood-dripping red letters...the Experienced will say in a chorus :oh f*ck.,,,,not again. not this crap anymore......" then they run to vomit but its too late because its all been absorbed so they wait for the inevitable..10..20 minutes...complete loss of skeletomuscular coordination. No memory of own name, and marked delirium. a few minutes after this, SLEEP. sleep lasts about 48 hours in the little EXPERIENCED and that involves crapping your pants cause you sure aint gona be able to wake up in the night. and for the EXPERIENCED armanis, its a deep 12-15 hour sleep from which naught but even a banshee can waken thee.

But 200 ... and 500 the next day with beer or whatever else was in that whole little tale (someone forgot to take their thiothixene apparently, while composing this gem of a story), You would be a pretty little corpse in about one hour. No vomiting. No screaming. Nothing. Pure, simple, Roche-class first class upper west side penthouse sleek black steinway DEATH.


so stop writing all of this garbage...whats the point. you know its a lie. we know it too.

what DO YOU REALLY WANT to know? and WHY ask it here? are you that,....

nevermind. je m'exscuse.

Morphinator
21-02-2008, 10:28
Ham-milton,

I can't say anything of alprazolam (for the simple reason that I haven't read studies or heard of overdose cases involving alprazolam alone), but I have read some disturbing things about OD situations with only a single benzo being responsible. I will show some examples when I dig them up for you.

Nitrazepam, temazepam, and flunitrazepam have all been involved in many overdose deaths without the consumption of alcohol, narcotics, or any other drug. Cases involving other benzodiazepines which have caused death from an overdose (without the consumption of any other drugs) include triazolam and flurazepam.

dboymagic
21-02-2008, 10:38
talk about barred out! i dont think it is okay at all to do that much!

Valium
21-02-2008, 11:01
MORPHINATOR speketh in ful trothe.


700mgs of alprazolam powder in 36 hours.....

my favorite part is how she took over 200mg the night before, and then woke up in the morning to take 700 and was walking around sipping a beer nonchalantly.



honestly...i understand it's mean that they restrict internet use in some psych wards, but this is a case where the patient is harming himself by delving further into delusion land here on the in ter net. sad stuff.


"um yea...ill be there in an hour, im getting ready. im so nervous though....how much xanax should i take?

how much is that?

oh mm okay so like thats what 5 handfuls about? right? uh huh. ok fine. no prob.

what?


oh i cant use water?


but i dont like whisky.


fine fine, stop screaming. ill be there.

bye.

glub glub glub
rattle
rattle

there goes a mule
with a corpse on his saddle.

- Federico Garcio Xorca

Ham-milton
21-02-2008, 11:29
Ham-milton,

I can't say anything of alprazolam (for the simple reason that I haven't read studies or heard of overdose cases involving alprazolam alone), but I have read some disturbing things about OD situations with only a single benzo being responsible. I will show some examples when I dig them up for you.

Nitrazepam, temazepam, and flunitrazepam have all been involved in many overdose deaths without the consumption of alcohol, narcotics, or any other drug. Cases involving other benzodiazepines which have caused death from an overdose (without the consumption of any other drugs) include triazolam and flurazepam.

And what do those benzos have in common? They're all hypnotics and extremely amnesic.

The first three also have inherent toxicity that makes even normal doses potentially dangerous for some people. Temazepam is the worst, as I recall. I forget the specifics of their toxicity, and it's 3:30am here, but I'll look it up in the morning.

I don't know why, but for some reason I also seem to remember them having the lowest therapeutic ratios (ED50/LD50)

smokester
21-02-2008, 12:13
^The nitro-containing compounds form superoxide free radicals. The downside of clonazepam is also its neurotoxicity. Alprazolam at least isnt, much like diazepam.

Morphinator
21-02-2008, 13:36
And what do those benzos have in common? They're all hypnotics and extremely amnesic.

The first three also have inherent toxicity that makes even normal doses potentially dangerous for some people. Temazepam is the worst, as I recall. I forget the specifics of their toxicity, and it's 3:30am here, but I'll look it up in the morning.

I don't know why, but for some reason I also seem to remember them having the lowest therapeutic ratios (ED50/LD50)

Ham-milton, I got the major British study on the toxicity of different benzos and a study from the Karolinska Institute about hypnotic abusers that I thnk you'd find interesting.

British study first:


Benzodiazepines have a relatively high therapeutic index.[46] Death after admission is rare and due to respiratory depression with aspiration of gastric contents.[47] Over 10 years in the United Kingdom, however, 1512 fatal poisonings have been attributed to benzodiazepines with or without alcohol.[48] These were compared with prescription data to establish a fatal toxicity index (deaths per million prescriptions) for each benzodiazepine. Similar indices have been derived for antidepressants[49] and barbiturates.[50] There were clear differences between benzodiazepines. Of drugs frequently prescribed, temazepam by far had the highest number of deaths per million prescriptions at 11.9 (95% confidence interval 10.9 to 12.8); above that of some tricyclic antidepressants. In contrast, oxazepam had an index of 2.3 (1.2 to 3.4), and the average index for all benzodiazepines combined was 5.7.

Although there are potential sources of error in these studies,[51] a bias that would lead to differences between compounds was not identified.[52] Clinical studies can adjust for potential confounders which studies that use coronial data are unable to take into account. If differences between the benzodiazepines are supported by data from clinical studies this also adds credence to the fatal toxicity index which first noted these findings.

The aim was therefore to determine if temazepam caused more sedation and oxazepam less sedation than other benzodiazepines.

During 1991-3, 542 patients with benzodiazepine poisoning presented to the hospital, 239 of these patients, however, had ingested either more than one benzodiazepine or co-ingested other sedating drugs. The drugs ingested by the remainder were temazepam (64), oxazepam (45), diazepam (113), clonazepam (24), flunitrazepam (21), nitrazepam (18), others (18).

Details of coma scores and odds ratios of the benzodiazepines ingested showed that temazepam was significantly more toxic than most other benzodiazepines.[53] Two out of the 45 subjects (4%) who ingested oxazepam were stuporous or comatose, 38 out of the 194 subjects (19%) who ingested other benzodiazepines (clonazepam, diazepam, flunitrazepam, nitrazepam and others) were stuporous or comatose, while 16 out of the 64 subjects (25%) who ingested temazepam were stuporous or comatose. None of the oxazepam subjects were comatose, 16 out of the 194 subjects (8%) who ingested other benzodiazepines were fully comatose, and 9 out of 64 subjects (14%) who ingested temazepam were fully comatose.

The results show that there are differences between temazepam, oxazepam, and other benzodiazepines in the degree of sedation they cause in overdose, and the observed differences are not due to confounding by age, sex, dose ingested, co-ingestion of alcohol, chronic benzodiazepine use, or history of drug or alcohol abuse. This provides a plausible explanation why temazepam and oxazepam have different fatal toxicity indices from other benzodiazepines.[54]

The sedation produced by benzodiazepines in therapeutic doses and overdose has a poor correlation with measured drug concentration but is increased with rapid absorption.[55][56][57][58] Temazepam is more rapidly absorbed and oxazepam is more slowly absorbed than other benzodiazepines.[59][60][61][62][63] Further research is required to determine if the rate of absorption is different in overdose and is sufficient to explain the differences in sedation. Slowing the rate of absorption may reduce toxicity, but this would also reduce their sedative effect in therapeutic doses.[64] Drug regulatory authorities should be aware that changes in formulation of benzodiazepines may affect toxicity in overdose.

Pharmacodynamic factors such as benzodiazepine receptor affinity and potency may also be important. Because of the wide variations in half life, adjustments for dose by conversion into defined daily doses or diazepam equivalents is imperfect.[65] These are designed to compare use rather than potency. Though they correlate reasonably well with sizes of prescriptions and tablets, they may not account for potency per tablet taken in overdose.[66]

SOURCES:

Gaudreault P, Guay J, Thivierge RL, Verdy I (1991). "Benzodiazepine poisoning. Clinical and pharmacological considerations and treatment". Drug Saf 6 (4): 247–65. PMID 1888441.

Höjer J, Baehrendtz S, Gustafsson L (1989). "Benzodiazepine poisoning: experience of 702 admissions to an intensive care unit during a 14-year period". J. Intern. Med 226 (2): 117–22. PMID 2769176.

Serfaty M, Masterton G (1993). "Fatal poisonings attributed to benzodiazepines in Britain during the 1980s". Br J Psychiatry 163: 386–93. PMID 8104653.

Cassidy S, Henry J (1987). "Fatal toxicity of antidepressant drugs in overdose". Br Med J (Clin Res Ed) 295 (6605): 1021–4. PMID 3690249.

Johns MW (1977). "Self-poisoning with barbiturates in England and Wales during 1959-74". Br Med J 1 (6069): 1128–30. PMID 861497.

Dwyer PS, Jones IF (1984). "Fatal self-poisoning in the UK and the paracetamol/dextropropoxyphene combination". Hum Toxicol 3 Suppl: 145S–174S.

Serfaty M, Masterton G (1993). "Fatal poisonings attributed to benzodiazepines in Britain during the 1980s". Br J Psychiatry 163: 386–93.

Buckley NA, Dawson AH, Whyte IM, O'Connell DL (1995). "Relative toxicity of benzodiazepines in overdose". BMJ 310 (6974): 219–21.

Serfaty M, Masterton G (1993). "Fatal poisonings attributed to benzodiazepines in Britain during the 1980s". Br J Psychiatry 163: 386–93.

Gaudreault P, Guay J, Thivierge RL, Verdy I (1991). "Benzodiazepine poisoning. Clinical and pharmacological considerations and treatment". Drug Saf 6 (4): 247–65.

Busto U, Kaplan HL, Sellers EM (1980). "Benzodiazepine-associated emergencies in Toronto". Am J Psychiatry 137 (2): 224–7.

Fuccella LM, Bolcioni G, Tamassia V, Ferrario L, Tognoni G (1977). "Human pharmacokinetics and bioavailability of temazepam administered in soft gelatin capsules". Eur. J. Clin. Pharmacol 12 (5): 383–6.

Greenblatt DJ, Harmatz JS, Engelhardt N, Shader RI (1989). "Pharmacokinetic determinants of dynamic differences among three benzodiazepine hypnotics. Flurazepam, temazepam, and triazolam". Arch. Gen. Psychiatry 46 (4): 326–32.

Gaudreault P, Guay J, Thivierge RL, Verdy I (1991). "Benzodiazepine poisoning. Clinical and pharmacological considerations and treatment". Drug Saf 6 (4): 247–65.

Busto U, Kaplan HL, Sellers EM (1980). "Benzodiazepine-associated emergencies in Toronto". Am J Psychiatry 137 (2): 224–7.

Fuccella LM, Bolcioni G, Tamassia V, Ferrario L, Tognoni G (1977). "Human pharmacokinetics and bioavailability of temazepam administered in soft gelatin capsules". Eur. J. Clin. Pharmacol 12 (5): 383–6.
Greenblatt DJ, Harmatz JS, Engelhardt N, Shader RI (1989). "Pharmacokinetic determinants of dynamic differences among three benzodiazepine hypnotics. Flurazepam, temazepam, and triazolam". Arch. Gen. Psychiatry 46 (4): 326–32.

Mitler MM (1981). "Evaluation of temazepam as a hypnotic". Pharmacotherapy 1 (1): 3–13.
Fuccella LM, Bolcioni G, Tamassia V, Ferrario L, Tognoni G (1977). "Human pharmacokinetics and bioavailability of temazepam administered in soft gelatin capsules". Eur. J. Clin. Pharmacol 12 (5): 383–6.

Alexander B, Perry PJ (1991). "Detoxification from temazepam: schedules and strategies". J Subst Abuse Treat 8 (1-2): 9–17.

Serfaty M, Masterton G (1993). "Fatal poisonings attributed to temazepam in Britain during the 1980s". Br J Psychiatry 163: 386–93.

Morphinator
21-02-2008, 13:53
^The nitro-containing compounds form superoxide free radicals. The downside of clonazepam is also its neurotoxicity. Alprazolam at least isnt, much like diazepam.

Well neither of those benzos will fry your brain some certain ones will.

[
]Withdrawal from certain hypnotic benzodiazepines are often more problematic and are often difficult to manage. Some hypnotics include nitrazepam (Mogadon®), temazepam (Restoril®), flurazepam (Dalmane®), triazolam (Halcion®), flunitrazepam (Rohypnol®), flutoprazepam (Restas®), and nimetazepam (Ermin®).

Neuropsychological function can be permanently affected by abuse of certain hypnotic benzodiazepines (temazepam, nitrazepam, flunitrazepam, flutoprazepam, and nimetazepam were found to be particularly toxic), with brain damage similar to alcoholic brain damage, as was shown in a 4– to 6-year follow-up study of hypnotic abusers by Borg and others of the Karolinska Institute. The CT scan abnormalities showed dilatation of the ventricular system. However, unlike alcoholics, hypnotic abusers showed no evidence of widened cortical sulci. The study concluded that, when cerebral disorder is diagnosed in hypnotic benzodiazepine abusers, it is often permanent.[5] An earlier study by Borg et al. found evidence of cerebral disorder in those that exclusively abused hypnotic benzodiazepines, suggesting that cerebral disorder was not the result of other substances of abuse. Anxiolytic benzodiazepines, such as diazepam, clonazepam, alprazolam, bromazepam and lorazepam were not found to have the same toxic properties of most of the hypnotics.[6]

The brain damage associated with chronic hypnotic benzodiazepine abuse and withdrawal is an effect rarely, if ever reported among anxiolytic benzodiazepines such as alprazolam (Xanax®), diazepam (Valium®), clonazepam (Rivotril®; Klonopin®) and other similar anxiolytics. There are reports in the medical literature of at least six psychotic states developing after abrupt withdrawal from temazepam including delirium, paranoia, and suicide ideation after abrupt withdrawal of only 30 mg of temazepam and in other cases, auditory and visual hallucinations and visual cognitive disorder developed after abrupt withdrawal from 10 mg of temazepam, 5 mg of nitrazepam and 0.5 mg of triazolam. Two psychotic states developing after abrupt withdrawal from nitrazepam has also been reported in medical literature. Chronic high dose abuse of flutoprazepam and nitrazepam have been linked to speech disorders such as stuttering and cluttering. Besides being linked to the development of speech or communication disorders, they have also been linked to cognition problems and balance disorders. Several studies have shown that moderate to high dose abuse of temazepam, nimetazepam, flutoprazepam, and flunitrazepam cause aphasia, dysnomia, delusional disorders, severe memory problems, motor coordination damage, and neurological problems. Depersonalisation has also been reported as a benzodiazepine withdrawal effect from doses as low as 5 mg temazepam, 7.5 mg flurazepam, and 2.5 mg nitrazepam.[7] The studies conducted by Borg et al. on chronic abusers of diazepam, alprazolam, bromazepam, lorazepam, and clonazepam never produced any kind of abnormalities in brain function, severe deterioration of memory, and speech and communication disorders. Depersonalisation was a withdrawal effect from 20 mg diazepam, 1.7 mg alprazolam, 1.8 mg clonazepam, 14 mg bromazepam, and 4.2 mg lorazepam. These findings suggest that depersonalisation occurs with temazepam, flurazepam, and nitrazepam at doses much lower than their therapeutic doses, whereas the anxiolytics required doses higher than their therapeutic doses to produce a depersonalisation withdrawal effect.

Abrupt withdrawal from very high doses is even more likely to cause severe withdrawal effects. Many well documented cases of withdrawal from high dose abuse of temazepam have caused severe hypoperfusion of the whole brain with diffuse slow activity on EEG. After withdrawal, abnormalities in hypofrontal brain wave patterns persist beyond the withdrawal syndrome and organic brain damage occurs from chronic high dose abuse of temazepam. Widespread abuse of temazepam has provided doctors, pharmacologists, and scientists with plenty of case studies, and as a result, temazepam withdrawal has been well known to cause a sudden and often violent death.[8] High dose abuse of nitrazepam, flunitrazepam, flutoprazepam, triazolam, nimetazepam, flurazepam, and a few other hypnotic benzodiazepines have also been known to cause abnormalities in brain function, including severe hypoperfusion of the whole brain with diffuse slow activity on EEG. Just like temazepam, abnormalities in hypofrontal brain wave patterns persist well beyond the withdrawal syndrome and brain damage occurs. However, cases are not as well documented in medical literature for most of the aforementioned hypnotics as is with temazepam.

Besides the well documented cases of chronic high dose abuse of temazepam and the life threatening withdrawal syndrome associated with it, flutoprazepam, nitrazepam, and triazolam have also been known to cause sudden and violent deaths during withdrawal.


SOURCES:

Borg S; Bergman H, Engelbrektson K, Vikander B. (1989). "Dependence on hypnotic benzodiazepines: neuropsychological impairment, field dependence and clinical course in a 5-year follow-up study.". British journal of addiction. 84 (5): 547-53.

Borg S; Bergman H, Holm L. (Feb 1980). "Neuropsychological impairment and exclusive abuse of hypnotics.". The American journal of psychiatry. 137 (2): 215-7.

Terao T, Yoshimura R, Terao M, Abe K (1992). "Depersonalization following nitrazepam, flurazepam, and temazepam withdrawal". Biol. Psychiatry 31 (2): 212–3

Kitabayashi Y, Ueda H, Narumoto J, et al (2001). "Chronic high-dose temazepam dependence 123I-IMP SPECT and EEG studies". Addict Biol 6 (3): 257–261.

Borg S. Sedative hypnotic dependence: neuropsychological changes and clinical course. Nord Pskiatr Tidsskr 1987; 41: Suppl 15: 17-19.[]

kadaj
21-02-2008, 15:37
It's not like we can taper her off, she just ate all of the fucking alprazolam. If she develops a super-tolerance from this, she's fucked because she actually does have panic disorders. Is there a step up on the benzo chain or any way to taper her off this shit with out having any more alprazolam? She is still prescribed valium.

ARGH THATS THE SAME GIRL THAT ATE ALL MY OC!!! Damn that girl! Glad she didn't die though lol... What up slackb0xed you know who this is. That girl needs to go to the psych ward for real. I'm sorry I don't know her very well and I don't care what kind of contributing/noncontributing member of society she might be she needs professional help on the real. Her benzo habit makes my IV opiate habit pale Antarctically in comparison.

kadaj
21-02-2008, 15:41
poor girl...


so stop writing all of this garbage...whats the point. you know its a lie. we know it too.

what DO YOU REALLY WANT to know? and WHY ask it here? are you that,....

nevermind. je m'exscuse.

I can tell you I know both the OP and SWIM and the only nonfactual part of the story is the supposed dose of "pure" alprazolam. It most likely was really that much powder, but I doubt it was that pure.

Armoth
21-02-2008, 16:29
this is obviously the same girl that asked how much valium it would take to kill her self, this is a harm reduction site, not a "hey i want to kill myself" site.

donkeyPUNCH
21-02-2008, 17:09
not that I've actually read most of the posts, but I CALL BULLSHIT.

biggerstronger
21-02-2008, 17:48
IMPOSSIBLE. That girl would be knocked out/blacked out for several days at the very least. She takes 20mg of valium per day! The story you tell is just not possible unless she is also shooting grams and grams of meth to keep her up along with it and is a walking zombie. Even then I would not believe it. Say she took 100mg of actual alprazolam instead of the 700mg that you said she would still be blacked out for a few of days.

700mg of alprazolam within a 2 day period alongside alcohol/lsd would have her on her death bed. Toxicity vs actual effect are two very different things. Although the dose may not be toxic to her body she would still have extreme effects from the huge dose including death if mixed with enough other drugs or alcohol. I believe this is a trolling attack people. lol.

Jamier
21-02-2008, 20:03
Alright im not trying to say you are lying here but cmon now 200mg of pure powder alprazolam thats 100 bars then 500 mgs thats equvilant to 250 bars no way... Thats all im saying maybe 20mg and 50 mg but the other numbers nope...

slackboxed
21-02-2008, 20:24
Well, the story is the best I could describe it while sort of in shell shock. SWIM did vomit several times through out the course of the night while we were playing video games.

To summarize what has happened since I posted that, the girl is still sleeping since she came down from all that acid and 500mgs for whatever fucking reason she had. The girl paid dirt for the alprazolam, nobody was paying attention to her and she just fucking ate the shit! Last thursday night maybe early friday morning she consumed 200mgs for whatever reason she had. Her whole weekend was a blur and then on tuesday night she consumes 500mgs. She sipped and killed maybe a beer to herself while she was fucked up/barred outter her mind.

Oh yeah, about the powder. SWIM obtains the shit from the North. Says the shit has been reliable for years and it has a very good purity. 98-99.7% pure alprazolam. I'm not fucking stupid though, I would never fuck around with this shit.

I've seen people who buy it just stick to a couch the second they buy it till they run out and that's pretty much the only reason they ever get up unless they gotta take a piss or drop the Cosbys off at the pool.

I gotta get on the road again everyone. Laters

LivingOnValium
21-02-2008, 20:35
That's quite a lot of alprazolam in a short period. I had 84mg of alprazolam (1mg Xanax IR) in less than 48 hours and don't recalll much of it.

Mugz
21-02-2008, 20:50
I found a study that says that alprazolam is more toxic in overdose than other benzos, it even mentions deaths from alprazolam alone, heres that abstract;



Alprazolam is relatively more toxic than other benzodiazepines in overdose

Dr Geoffrey K. Isbister, Emergency Department, Newcastle Mater Hospital, Edith St, Waratah

To describe alprazolam poisoning and the relative toxicity of alprazolam compared with other benzodiazepines.
Methods

A database of consecutive poisoning admissions to a regional toxicology service was searched to identify consecutive benzodiazepine deliberate self poisonings, which were coded as alprazolam, diazepam or other benzodiazepine. Major outcomes used were length of stay (LOS), intensive care (ICU) admission, coma (GCS < 9), flumazenil administration and requirement for mechanical ventilation. Prescription data were obtained for benzodiazepines for the study period.
Results

There were 2063 single benzodiazepine overdose admissions: 131 alprazolam overdoses, 823 diazepam overdoses and 1109 other benzodiazepine overdoses. The median LOS for alprazolam overdoses was 19 h which was 1.27 (95% CI 1.04, 1.54) times longer compared with other benzodiazepines by multiple linear regression. For patients with alprazolam overdoses, 22% were admitted to ICU which was 2.06 (95% CI 1.27, 3.33) times more likely compared with other benzodiazepines after multivariate analysis adjusting for age, dose, gender, time to ingestion and co-ingested drugs. Flumazenil was administered to 14% of alprazolam patients and 16% were ventilated, which was significantly more than for other benzodiazepine overdoses (8% and 11%, respectively). Twelve percent of alprazolam overdoses had a GCS < 9 compared with 10% for other benzodiazepines. From benzodiazepine prescription data, total alprazolam prescriptions in Australia increased from 0.13 million in 1992 to 0.41 million in 2001. Eighty five percent of prescriptions were for panic disorder, anxiety, depression or mixed anxiety/depression.
Conclusions

Alprazolam was significantly more toxic than other benzodiazepines. The increased prescription of alprazolam to groups with an increased risk of deliberate self poisoning is concerning and needs review.

haribo1
21-02-2008, 23:16
Is their a ceiling effect for benzos? After all, once all those GABA receptors are full, more won't do anything...

Lucky SeVen
21-02-2008, 23:31
Recently, SWIM ate about 200mgs of (pure powdered) alprazolam one night, drank with it, and then four days later she ate about 20 gel tab hits of lsd and while she was tripping she ate around 500mgs of alprazolam all at once. She is prescribed benzos so she had a little bit of a tolerance, but holy shit I have never seen anyone so fucked up on benzos before in my entire life! She actually drank beer an hour into it. I read up on erowid that it takes about ~330mgs-2000mgs to kill lab rats with alprazolam.

How much alprazolam do you think it would take to kill a 120lb girl with a slight benzo tolerance (she is prescribed 5mg valiums 4x a day)? We're talking some pure powder here, supposidely 98-99% pure unadulterated but who the hell knows now a days ya know?

Oh the dumbass girl is alright. No serious injuries occured somehow.

BULLSHIT!!! Swim is already dead. Or Swim is a liar. Or Swim is very wrong by stating she ate 200 mg's of alprazolam. Thats 100 bars. BULLSHIT!!!

burn out
21-02-2008, 23:39
Is their a ceiling effect for benzos? After all, once all those GABA receptors are full, more won't do anything...

there might be but the more you take the longer the receptors will stay full, plus there has to be some way they become toxic because there are reports on people overdosing on benzos alone. it's just very difficult to do.

Morphinator
21-02-2008, 23:43
I found a study that says that alprazolam is more toxic in overdose than other benzos, it even mentions deaths from alprazolam alone, heres that abstract;


That study was flawed and very limited. The study below is far larger and spanned over years of data. Look at the sources of the study. Several other studies have concluded the same thing as this, including a Swedish study and an Australian study, which I have posted on here before.


Benzodiazepines have a relatively high therapeutic index. Death after admission is rare and due to respiratory depression with aspiration of gastric contents. Over 10 years in the United Kingdom, however, 1512 fatal poisonings have been attributed to benzodiazepines with or without alcohol. These were compared with prescription data to establish a fatal toxicity index (deaths per million prescriptions) for each benzodiazepine. Similar indices have been derived for antidepressants and barbiturates. There were clear differences between benzodiazepines. Of drugs frequently prescribed, temazepam by far had the highest number of deaths per million prescriptions at 11.9 (95% confidence interval 10.9 to 12.; above that of some tricyclic antidepressants. In contrast, oxazepam had an index of 2.3 (1.2 to 3.4 ), and the average index for all benzodiazepines combined was 5.7.

Although there are potential sources of error in these studies, a bias that would lead to differences between compounds was not identified. Clinical studies can adjust for potential confounders which studies that use coronial data are unable to take into account. If differences between the benzodiazepines are supported by data from clinical studies this also adds credence to the fatal toxicity index which first noted these findings.

The aim was therefore to determine if temazepam caused more sedation and oxazepam less sedation than other benzodiazepines.

During 1991-3, 542 patients with benzodiazepine poisoning presented to the hospital, 239 of these patients, however, had ingested either more than one benzodiazepine or co-ingested other sedating drugs. The drugs ingested by the remainder were temazepam (64 ), oxazepam (45 ), diazepam (113), clonazepam (24 ), flunitrazepam (21 ), nitrazepam (1, others (1.

Details of coma scores and odds ratios of the benzodiazepines ingested showed that temazepam was significantly more toxic than most other benzodiazepines. Two out of the 45 subjects (4 who ingested oxazepam were stuporous or comatose, 38 out of the 194 subjects (19 who ingested other benzodiazepines (clonazepam, diazepam, flunitrazepam, nitrazepam and others) were stuporous or comatose, while 16 out of the 64 subjects (25 who ingested temazepam were stuporous or comatose. None of the oxazepam subjects were comatose, 16 out of the 194 subjects (8 who ingested other benzodiazepines were fully comatose, and 9 out of 64 subjects (14 who ingested temazepam were fully comatose.

The results show that there are differences between temazepam, oxazepam, and other benzodiazepines in the degree of sedation they cause in overdose, and the observed differences are not due to confounding by age, sex, dose ingested, co-ingestion of alcohol, chronic benzodiazepine use, or history of drug or alcohol abuse. This provides a plausible explanation why temazepam and oxazepam have different fatal toxicity indices from other benzodiazepines.

The sedation produced by benzodiazepines in therapeutic doses and overdose has a poor correlation with measured drug concentration but is increased with rapid absorption. Temazepam is more rapidly absorbed and oxazepam is more slowly absorbed than other benzodiazepines. Further research is required to determine if the rate of absorption is different in overdose and is sufficient to explain the differences in sedation. Slowing the rate of absorption may reduce toxicity, but this would also reduce their sedative effect in therapeutic doses. Drug regulatory authorities should be aware that changes in formulation of benzodiazepines may affect toxicity in overdose.

Pharmacodynamic factors such as benzodiazepine receptor affinity and potency may also be important. Because of the wide variations in half life, adjustments for dose by conversion into defined daily doses or diazepam equivalents is imperfect. These are designed to compare use rather than potency. Though they correlate reasonably well with sizes of prescriptions and tablets, they may not account for potency per tablet taken in overdose.

SOURCES:

Gaudreault P, Guay J, Thivierge RL, Verdy I (1991). "Benzodiazepine poisoning. Clinical and pharmacological considerations and treatment". Drug Saf 6 (4): 247–65. PMID 1888441.

Höjer J, Baehrendtz S, Gustafsson L (1989). "Benzodiazepine poisoning: experience of 702 admissions to an intensive care unit during a 14-year period". J. Intern. Med 226 (2): 117–22. PMID 2769176.

Serfaty M, Masterton G (1993). "Fatal poisonings attributed to benzodiazepines in Britain during the 1980s". Br J Psychiatry 163: 386–93. PMID 8104653.

Cassidy S, Henry J (1987). "Fatal toxicity of antidepressant drugs in overdose". Br Med J (Clin Res Ed) 295 (6605): 1021–4. PMID 3690249.

Johns MW (1977). "Self-poisoning with barbiturates in England and Wales during 1959-74". Br Med J 1 (6069): 1128–30. PMID 861497.

Dwyer PS, Jones IF (1984). "Fatal self-poisoning in the UK and the paracetamol/dextropropoxyphene combination". Hum Toxicol 3 Suppl: 145S–174S.

Serfaty M, Masterton G (1993). "Fatal poisonings attributed to benzodiazepines in Britain during the 1980s". Br J Psychiatry 163: 386–93.

Buckley NA, Dawson AH, Whyte IM, O'Connell DL (1995). "Relative toxicity of benzodiazepines in overdose". BMJ 310 (6974): 219–21.

Serfaty M, Masterton G (1993). "Fatal poisonings attributed to benzodiazepines in Britain during the 1980s". Br J Psychiatry 163: 386–93.

Gaudreault P, Guay J, Thivierge RL, Verdy I (1991). "Benzodiazepine poisoning. Clinical and pharmacological considerations and treatment". Drug Saf 6 (4): 247–65.

Busto U, Kaplan HL, Sellers EM (1980). "Benzodiazepine-associated emergencies in Toronto". Am J Psychiatry 137 (2): 224–7.

Fuccella LM, Bolcioni G, Tamassia V, Ferrario L, Tognoni G (1977). "Human pharmacokinetics and bioavailability of temazepam administered in soft gelatin capsules". Eur. J. Clin. Pharmacol 12 (5): 383–6.

Greenblatt DJ, Harmatz JS, Engelhardt N, Shader RI (1989). "Pharmacokinetic determinants of dynamic differences among three benzodiazepine hypnotics. Flurazepam, temazepam, and triazolam". Arch. Gen. Psychiatry 46 (4): 326–32.

Gaudreault P, Guay J, Thivierge RL, Verdy I (1991). "Benzodiazepine poisoning. Clinical and pharmacological considerations and treatment". Drug Saf 6 (4): 247–65.

Busto U, Kaplan HL, Sellers EM (1980). "Benzodiazepine-associated emergencies in Toronto". Am J Psychiatry 137 (2): 224–7.

Fuccella LM, Bolcioni G, Tamassia V, Ferrario L, Tognoni G (1977). "Human pharmacokinetics and bioavailability of temazepam administered in soft gelatin capsules". Eur. J. Clin. Pharmacol 12 (5): 383–6.
Greenblatt DJ, Harmatz JS, Engelhardt N, Shader RI (1989). "Pharmacokinetic determinants of dynamic differences among three benzodiazepine hypnotics. Flurazepam, temazepam, and triazolam". Arch. Gen. Psychiatry 46 (4): 326–32.

Mitler MM (1981). "Evaluation of temazepam as a hypnotic". Pharmacotherapy 1 (1): 3–13.
Fuccella LM, Bolcioni G, Tamassia V, Ferrario L, Tognoni G (1977). "Human pharmacokinetics and bioavailability of temazepam administered in soft gelatin capsules". Eur. J. Clin. Pharmacol 12 (5): 383–6.

Alexander B, Perry PJ (1991). "Detoxification from temazepam: schedules and strategies". J Subst Abuse Treat 8 (1-2): 9–17.

Serfaty M, Masterton G (1993). "Fatal poisonings attributed to temazepam in Britain during the 1980s". Br J Psychiatry 163: 386–93.



Temazepam is a drug which is very frequently involved in drug intoxication, including overdose. Overdose of temazepam may result in excessive sedation, impairment of balance and speech. This may progress in severe overdoses to respiratory depression or coma and possibly death. The risk of overdose is increased if temazepam is taken in combination with alcohol, opiates or other CNS depressants. Temazepam overdose responds to the benzodiazepine receptor antagonist flumazenil.

Benzodiazepines were implicated in 39% of suicides by drug poisoning in Sweden, with temazepam, nitrazepam and flunitrazepam accounting for 90% of benzodiazepine implicated suicides, in the elderly over a period of 2 decades. In three quarters of cases death was due to drowning, typically in the bath. Benzodiazepines were the predominant drug class used in suicides in this review of Swedish death certificates with 72% of benzodiazepine overdoses showing that benzodiazepines were the sole drug used in deaths by overdose. Benzodiazepines and in particular temazepam, nitrazepam and flunitrazepam should therefore be prescribed with caution in the elderly. Nitrazepam, and especially temazepam were the benzodiazepines most commonly detected in overdose related drug deaths in an Australian study of drug deaths. The two benzodiazepines were found to be the sole cause of death in one third of cases.

In a retrospective study of deaths, when benzodiazepines were implicated in the deaths, the benzodiazepines flunitrazepam, temazepam and nitrazepam were the most common benzodiazepines involved. Benzodiazepines were a factor in all deaths caused by drug addiction in the study. Temazepam, nitrazepam and flunitrazepam were significantly more commonly implicated in suicide related deaths than natural deaths. In four of the cases benzodiazepines alone were the only cause of death. It was concluded that flunitrazepam, nitrazepam, and temazepam were significantly more toxic than other benzodiazepines.

From a research perspective, there are several data acquired through scientific research that suggest temazepam is more frequently involved in drug-related deaths than are all other benzodiazepines. Temazepam is also the benzodiazepine that is by far the most commonly targeted in pharmacy burglaries and prescription forgeries.

SOURCES:

Zevzikovas A, Kiliuviene G, Ivanauskas L, Dirse V (2002). "[Analysis of benzodiazepine derivative mixture by gas-liquid chromatography]" (in Lithuanian). Medicina (Kaunas) 38 (3): 316–20.

Carlsten, A; Waern M, Holmgren P, Allebeck P (2003). "The role of benzodiazepines in elderly suicides". Scand J Public Health 31 (3): 224-8.

Drummer OH; Ranson DL (Dec 1996). "Sudden death and benzodiazepines". Am J Forensic Med Pathol 17 (4): 336-42.

Ericsson HR, Holmgren P, Jakobsson SW, Lafolie P, De Rees B (1993). "[Benzodiazepine findings in autopsy material. A study shows interacting factors in fatal cases]" (in Swedish). Lakartidningen 90 (45): 3954–7.

Injecting Temazepam -- Temazepam Injection and Diversion. Victorian Governmant Health Information (29 March, 2007).

Morphinator
21-02-2008, 23:48
Benzodiazepines have always been regarded as remarkably non-toxic drugs. However, they are not completely safe. They are involved in up to 40% of all self poisoning incidents. Between 1980 and 1989 there were 1512 suicides attributed to benzodiazepine overdose. In 2/3 of these cases the drug was taken alone, in 1/3 with alcohol.

Temazepam, the commonest hypnotic used today, turned out to be the most toxic. The risk of a fatal outcome form benzodiazepine overdosage is greatly increased in the elderly and in people with lung disease, and benzodiazepines increase the risks of fatality if taken with many other drugs not included in this analysis. The combination of benzodiazepines with opiates causes almost 100 deaths each year among drug abusers in Glasgow alone. The cause of benzodiazepine fatalities is depression of respiration: They impair function in brain centres vital for breathing.

That's from the ultimate source on Benzos online - http://www.benzo.org.uk/ashspeech.htm

FractalStructure
22-02-2008, 03:07
those are some hardcore doses... luckily benzos have a very high safety margin (it takes ridiculous amounts to overdose, i mean, lethally). I mean, I usually dont feel even 12mg of clonazepam while im trying to overpower a speed or mdma crash... but in the triple digits? ALPRAZOLAM!? shit. like, even with the much less potent diazepam those are insane doses...

^Temazepam is most toxic? That sucks cuz it happens to be among my favorite benzos (yeah, i know, many will disagree but something about the hypnotic benzos, they feel different, and better IMO. Flurazepam is nice too but not as nice)

But I mean, in response to this article... Is it really a surprise that temazepam is more sedating? a 60mg dose can knock me out, while 6mg of alprazolam doesnt even come close... again, I think they just work differently (the anxiety vs hypnotic benzos, not even -pam or -lam)

Nickatina
22-02-2008, 03:19
Her whole weekend was a blur and then on tuesday night she consumes 500mgs. She sipped and killed maybe a beer to herself while she was fucked up/barred outter her mind.

BULL-FUCKING-SHIT. Someone who has dosed a half a gram of xanax is unable to walk, speak coherently, and is almost definitely passed-the-fuck-out. There is no way she would be able to drink a beer with it.

Why do people make up stupid stories like this? I don't care what kind of tolerance you have, no one has one high enough in that it would be possible.

You are the kind of people that give fodder to the anti-drug warriors. Fuck off with this shit, you just killed my god damned buzz.

burn out
22-02-2008, 03:29
actually, i think it might be possible if you spent years building a tolerance but the point is he also said she had a low benzo tolerance so that makes it pretty unbelievable. i can recall instances of being put out like a light bulb from doses around 4 or 5 mg of xanax. i don't see how someone without a tolerance could remain awake on 500 mgs.

Nickatina
22-02-2008, 03:38
^ Right! He mentioned a low tolerance but even if you had one of say, 20mg (which is rather high), and you proceeded to take 25x that amount, then that is similar to a first timer taking 25 bars and there is no fucking way they will be conscious. I know it is POSSIBLE, but it would be some kind of a miracle.

Ham-milton
22-02-2008, 03:49
Is their a ceiling effect for benzos? After all, once all those GABA receptors are full, more won't do anything...

A lot of benzos effects are due to their effect of potentiating GABA, and partly due to their actions as direct agonists.

It's a pretty complicated subject, but it seems unlikely.

Ham-milton
22-02-2008, 03:54
IMPOSSIBLE. That girl would be knocked out/blacked out for several days at the very least. She takes 20mg of valium per day! The story you tell is just not possible unless she is also shooting grams and grams of meth to keep her up along with it and is a walking zombie. Even then I would not believe it. Say she took 100mg of actual alprazolam instead of the 700mg that you said she would still be blacked out for a few of days.

700mg of alprazolam within a 2 day period alongside alcohol/lsd would have her on her death bed. Toxicity vs actual effect are two very different things. Although the dose may not be toxic to her body she would still have extreme effects from the huge dose including death if mixed with enough other drugs or alcohol. I believe this is a trolling attack people. lol.

Except that nothing you've said is based in fact. With very limited alcohol intake, it could easily be survived. The LSD would have no effect on toxicity.

Like I said earlier, with an LD50 above 1g/kg, 500mg doesn't even begin to approach a lethal dose. Assuming very little alcohol was consumed, there's no reason to believe she couldn't survive this.

To stay awake on it, however? I dunno.

andyman1109
22-02-2008, 04:27
Can you say coma? 500 mgs, right. Maybe if she was superman...

Ham-milton
22-02-2008, 04:29
sleep =/= coma.

williamrobinson57
07-03-2008, 04:41
This is a true story but the names have been altered while times and dates unaltered.

Last Wednesday, a friend of mine (Robert) recieved about 8g of alprazolam after paying for 100g, but thats another story. He needed to test it and Edward (5'10", 280lb), who is a die hard benzo user, was a willing participant. I instructed him that one dose of alprazolam powder is 2mg (quad bar), and that we don't have the scale to measure that amount. I said the best thing to do is give him a grain at a time, up to 3. Well, Robert has a scale that will measure 0.1g's so he measured that amount thinking that it was a total of 5 Xanax 2mg pills.

Well, later that day (20 min. later) i recieved a phone call about how fucked he was. They thought it was the funniest thing ever. I asked how much they gave him and was told only 1/10th of a gram not realizing they gave him 50 quads.

Upon realizing what they had done, I instructed that they need to watch him closely because we are all parties that contributed if something goes wrong. Don't let him drive, shower, bathe, drink alcohol, snort cocaine, nothing. That struck a nerve with everybody, but it gets worse.

(45mins later) I recieve a phone call that he is throwing up all over himself and inside Roberts car. Now this is good news to me, because powder alprazolam comes in a crystalized form. Anyone familiar enough with the drug knows that in the process oof making pills, while mixing with fillers, you run it through a (sieve) 250 micron screen to allow it to mix evenly as well as allowing for quicker absorbtion. With that step being skipped, he probably was able to get some out.

(1:45 min into it) He starts nodding out. He wants to go to sleep. I tell everyone they have to options, A. force him to stay awake or B. somebody will stand guard and make sure he doesn't choke on throw up or spit (Major cause of death from benzo only OD). They opt for option A.

(5hrs into) Edward seems to start coming around and Robert thinks it's fine to take him out to run errands. After running some errands, Robert decides they should get their hair cut. Edward get's his and seems to be doing well, fully coherent. When Robert gets his, Edward just wants to listen to the radio and lie down in the car. Robert sees nothing wrong with this.

(7hrs. into, and 5min. after Edward goes to car) I recieve a phone call. "That mother fucker drove off (Major cause of death w/benzos) in my car (2006 Cadillac w/20" wheels and customs). Come pick me up, NOW, PLEASE!" I go to pick him up, and we have an idea where he went. We take the route he would have taken, because I was 100000000000% sure he would crash. While going down the street we notice an unusual amount of construction signs litter the road. He must have gone that way. As we pull into the neighborhood, we see a bunch of cop cars and a Robert's cadillac had plowed through a SOLID brick mailbox (not the usual hollow ones). The front was propped on the mailbox stump, and the front tires couldn't reach the ground. Edward was arrested for DUI.

I convince Robert it's not entirely his fault, so after many hours of arguing I convince him that he should bond him out and only hold him accountable for 50% of the repair. We gave Edwards mother the money, and she let him sit there for a couple days. When I talked to him Tuesday, he swears he has no recollection of the events, apologizes, and agrees to pay 50%.

Just think though, it could have been a family in another vehicle in an intersection. I consider us fortunate.

Tbird921
07-03-2008, 07:02
Not trying to be a ass or anything, but this doesn't seem that beliveable to me, 20 hits of good acid and 500mg of xanax and shes only weighs 120 pounds, I've seen people black out from 3-5mg of xanax before who were close to 200 pounds, I also seen people black out from taking upwards of 10+ hits of good LSD. If it is true, the 20mg valium she was taking each day wouldn't even touch her and when she stops she is going to be in absolute hell, like the guy in the youtube video.

Nickatina
07-03-2008, 07:10
That's xanax for you, will robinson. Only reason why I got a DUI too. Luckily I didn't hit anyone, but I did catch up to a undercover cop that passed me going 90 mph. And I didn't have shoes. That stuff makes you do very stupid stuff.

thugpassion
07-03-2008, 08:23
That much alprazolam and lsd sounds like bullshit. Both those amounts of drugs could cause serious problems for a person even with a decent tollerance. I think your amounts are way off, or somebody is totaly lyeing.

andyman1109
07-03-2008, 20:11
Ok, first of all, what's the deal with this "pure alprazolam powder"? I've seen this on here a few times and it just seems strange. I guess there are clandestine labs producing illicit, pure alprazolam?

Anyway, when I first read this, I thought it was total bullshit and this was a lie or the girl was dead. After doing a little research, it would SEEM that a person could hypothetically survive a dose of that magnitude. However, one would be extremely lucky to survive without going into coma, inducing seizure, or suffering brain damage from severe respiratory depression. Also, at such a high dose, any other depressants ingested would almost certainly spell doom. Even the single beer consumed in this report could potentially put you over the edge.

I would say, IFF this report is true, this girl is very very lucky to be alive and would be well advised to never do something like this again.

More likely what happened is that the amounts in this story are inaccurate, which could quite easily be the case, seeing as that this 'pure alprazolam powder' could have been anything. It could have been 1% pure, it could have been sugar, no one knows. Much different than if she had consumed say, 1000 peaches lol

Also, in the event this story is true, I believe the stimulating effects of the LSD could actually have helped her situation, helping to keep her from sleeping. LSD is powerful stuff.

williamrobinson57
07-03-2008, 22:15
Ok, first of all, what's the deal with this "pure alprazolam powder"? I've seen this on here a few times and it just seems strange. I guess there are clandestine labs producing illicit, pure alprazolam?

Actually, there the same labs that make the chemical for a lot of the generics worldwide. They are GMP, and ISO 9001 certified. They will provide the certificate of analysis for the batch. The catch is, most won't export without an import permit. So, if you were interested in aquiring this chemical, you would have to find a work around...




More likely what happened is that the amounts in this story are inaccurate, which could quite easily be the case, seeing as that this 'pure alprazolam powder' could have been anything. It could have been 1% pure, it could have been sugar, no one knows. Much different than if she had consumed say, 1000 peaches lol?


I'm would say if the amounts were inaccurate, the person who sold it to her dilluted it. In fact, if there was even a hint of sweetness in the flavor, it's not alprazolam. Alprazolam USP27 is very bitter tasting, sort of like an extra strength tylenol powdered. Most medical grade powder is 98%+, but never pure.

rave23
07-03-2008, 22:49
Recently, SWIM ate about 200mgs of (pure powdered) alprazolam one night, drank with it, and then four days later she ate about 20 gel tab hits of lsd and while she was tripping she ate around 500mgs

700 mgs Xanax
20 hits LSD
in 4 days...

175 mg xanax
5 tabs of acid
every day...

that's almost 3 months worth of perscription xanax every day.

Holly fucking shit... You might as well just not do that again, cause you won't remember shit ;)

morphinedreams
08-03-2008, 12:34
wow. what a combo. how's her sanity? just a couple doses makes me feel pretty loopy.