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Thread: (Loperamide/96 mgs) Experienced: YES, I'm high.

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    #51
    Bluelighter funkee's Avatar
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    I took 48mg to combat withdrawal, no high whatsoever. Though my shits have stopped, 10 hours and counting............................
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    #52
    Bluelighter chrlefxtrt's Avatar
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    130mg of loperamide gave me a codeine-esqe buzz. I posted on th OP's other thread my experiences with it. It works for me and that is all I care about. For those interested, I also shit normally after two days and the effects lasted over 8hrs for me.
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    #53
    ^^Why do you assume this is placebo. Have you or anyone you know personally ever attempted to take a high dose like these here -of loperamide to get opiate effects? If so, at what dosages, if not why are you posting such comments?
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    #54
    Shadowmeister
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    I think it's quite amusing that whenever anyone hears anything about certain substances, such as loperamide, that they immediately assume placebo effect. Have you tried it? If not, then what basis do you have for making such an assertion? I'm going to start deleting posts that don't add anything to the discussion, which includes and is primarily targeted at these "OMG placebo!!!1" posts. They're pointless and insulting to the OP and anyone else who is asserting that loperamide can provide more than placebo effect (including myself). I've received effects from loperamide multiple times, and I'm very much experienced with drugs of all kinds so I think I'm more than capable of discerning real effects from placebo.

    It's like people have some sort of reactionary defense mechanism in place against people reporting effects from certain medications, like loperamide, and, strangely, neurontin, which most assuredly does have effects (and good ones at that). If you don't have anything useful to add, then don't post. Why do you feel the need to try to humiliate the OP? What good is that doing anyone?

    I just don't get it. But what I do get is the power to moderate this forum. So please keep your useless comments to yourselves. Thank you.
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    loperamide-inexperienced-first try as mental and physical withdrawal aid 
    #55
    I too was surprised and disappointed at the closed-mindedness here.

    I was in mild withdrawal after tapering from H (iv) with vics. So not too far out of the woods, when yesterday, while feeling nasty digestive symptoms and mental issues such as depression and cravings, I popped 18 pills of 2mg loperamide (36mg). I had slightly crushed them. I didn't have much expectations. My previous experience with this as a withdrawal aid was mostly at recommended doses or above, which it didn't do much for me besides ease my stomach.

    After an hour, I thought, well this isn't working beyond my stomach. I felt it doing something in my gut and easing the tension which was there. Two hours later and it was the same; I still had my mental issues and pain/mild twitching going on. I figured that people dont take into account that they are dehydrated during withdrawal, and loperamide will ease this, leading to some physical and mental ease. I still believe this is partly its mechanism of action.

    However, after about 150 minutes I definitely noticed a relief. Fatigue lessened. Mentally my depression faded and the pains subsided. This effect lasted into today, which is about 18hrs later, although I had some runs this morning (which I was happy to have since I was somewhat concerned about having bad constipation). Cravings are still absent. I hope I don't crash too hard when it all leaves my system. I also slept very well which was definitely due to CNS activity on my opioid system.

    So my conclusion is, it does get into the CNS for me at this dose, definitely not getting me high but relieving the withdrawal like a dose of codeine would. Better than tramadol for sure but I never got much from that with my tolerance. Also I still believe it works by allowing one to absorb water out of the intestines to hydrate the body, and hydration can cause both physical and mental parts of what one thinks is just withdrawal, to go away.

    I once read a scientific article about how MDMA damages the BBB. I hope that isn't why this worked for me; I've done X about 15 times.

    Good find. Thank you for bringing this up, malfunkshun, you have helped me out.
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    #56
    Bluelighter lucid scream's Avatar
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    Quote Originally Posted by mr light

    I was in mild withdrawal after tapering from H (iv) with vics. So not too far out of the woods, when yesterday, while feeling nasty digestive symptoms and mental issues such as depression and cravings, I popped 18 pills of 2mg loperamide (36mg). I had slightly crushed them. I didn't have much expectations. .
    yeah, you wont get any relief taking the dose recommended on the box. it is an opiod, and there is a cross-tolerance, so you have to dose equivalent to your tolerance for your DOC.
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    #57
    Bluelighter The Monkey Mantra's Avatar
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    I've taken loperamide at doses of up to 96 mg when I wasn't withdrawing, and maybe 48 mg when I was withdrawing from percocet after a long hospital stay.

    The 96 mg dose made me sleep a *lot*. I wasn't really euphoric or anything, but I had the frog-in-the-throat sensation and a *definite mellowness*.

    When I took 48 mg to alleviate Percocet withdrawal symptoms it totally worked. I just felt normal. No hot-cold goosebumps and aches or anything.
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    #58
    Bluelighter QuasiStoned's Avatar
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    I believe that it really takes a while for the loperamide to get through the BBB. It seems to me that while withdrawing, it takes about 2 hours before I start to feel some sort of relief. Then as time goes on the relief slowly increases.

    I took 30mg last night, felt better after a few hours, slept okay. Now today I'm not even yawning anymore, and I'm at the 24 mark from loperamide, and 72 hour mark from pods. Note that I'm withdrawing from Poppy pod tea which has an incredible half life (I could probably quit cold turkey and withdraw for 7 - 10 days as all the morphine gets metabolized and feel worse each day) but this is still saying something in favor of loperamide.

    EDIT
    If I hadn't taken the loperamide last night I'd be squirming around uncomfortably at this point.
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    #59
    Hey malfunkshun, I believe you.

    !!!
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    #60
    Bluelighter diche's Avatar
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    holy gutrot batman
    96 pills, yeah ur gonna feel something, eck!
    I can barely stomach 30 pills, and those were dxm

    but who am I to judge, you felt great off Loperamide, nuff said
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    #61
    Shadowmeister
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    Quote Originally Posted by QuasiStoned
    I believe that it really takes a while for the loperamide to get through the BBB. It seems to me that while withdrawing, it takes about 2 hours before I start to feel some sort of relief. Then as time goes on the relief slowly increases.
    I agree with that. Early yesterday morning I woke up withdrawing from kratom, so I took 48mg of loperamide. It took about 2 hours for me to stop feeling the need to squirm, although I was still uncomfortable, but it became bearable and I could sleep some at last. Then a little later, probably 5 hours into the loperamide (which did not provide a high but just a heavy feeling and relief from withdrawal), I took half my normal dose of kratom, which was all I had left. Normally I would not even feel it, but with loperamide already in play, I got a fantastic kratom high, stronger than it's been in years. I even started nodding a bit, which kratom doesn't normally even have the ability to do because it's a stimulating opiate-ish thing. It also lasted hours longer.
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    #62
    Bluelighter QuasiStoned's Avatar
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    ^^^
    I used to actually use loperamide with success to potentiate my kratom. It really does work!

    If loperamide were completely peripheral, how would it be relieving our withdrawals so well?? It's ridiculous how everyone argrues about the BBB when it's clear that it is able to get through somewhat.
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    #63
    Something makes me think Immodium sales are going to start going up LOL.

    I'm going to give it a try next time i have nothing to keep the withdrawal away.

    And i to believe everyone who says they got some kind of affect from it at the different levels they report. I also agree that some people are being closed-minded about Loperamide. It's the same kind of slight prejudice you get from some people and poppy seed tea. There are a few people on various groups like Bluelight AND Bluelight who just refuse to believe that poppy seed tea works. On one group, a while back on person made this long post on how he refused to believe it worked (because it didn't work for hm) and said anyone who felt anything was simply feeling a placebo. Arghhhh, that made me so mad. Poppy seed tea, firstly... it can be a hit or miss, and secondly it depends on how much it was washed and also it depends on your tolerance.

    The first time i did poppy seed tea i was a Tramadol addict so my tolerance to stronger opiates was somewhat low although prior to Tramadol my DOC was Vicodin, so i had a mild tolerance. But that first batch of poppy seed tea i had gave me one of the greatest highs I'd ever had up to that time in my life. My god, it was such a beautiful high. I could feel it all through my body and my legs felt like they were floating. Odd thing was, it took 2 hours to kick in. So at first i thought... awww shit, it didn't work, or i didn't use enough. But 2 hours later i was eating a bowl of cereal when it started to kick in and OMG, what a great night that was. Of course now my tolerance is so high because I've been on Oxy and Fent. But poppy seed tea will still take care of any withdrawal i have for about 12 hours and i will get a very mild buzz. So i can always count on it for w/d, but if I'm broke PST isn't an option, that's one downfall for me and pst.

    Also some people have the same reaction to Tramadol. Just because it didn't work for them or they didn't like it, it sucks PERIOD, no ands, buts or ifs about it. But that isn't the case, Tramadol is tricky little fellow. It depends on a persons system/chemistry and a lot of people are expecting that true-opiate feeling and when they don't get it-- Tramadol sucks period! You have to go into it knowing you won't get that classic opiate high, tramadol offers a very different kind of high. I was one of the lucky people who could get super high off of it and even nod from it occasionaly. But because I've moved up the opiate trail Tramadol doesn't work as well as it used to but i use it as a potentiator sometimes and i also use it for w/d sometimes. It doesn't work for w/d as good as it used to but it still helps. Tramadol works great with Poppy pods, it's a great mix (for me). Tramadol and poppy seed tea although are myths to some people, have been great friends of mine and always will be.

    So i am a believer in this Loperamide. I'm not saying your going to get an oxy or fent high from it but i do believe it is beneficial in many ways and all the people who report feeling a mild buzz or report their w/d easing.. i totally believe you. Whenever i get a chance to give it a try I will report my experience.

    This is a great thread. I'd love to hear more people's reports and not so many "It's a damn placebo people" comments.

    RPG
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    Vicodin 
    #64
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    Vicodin usually does the job. I always seem to throw up after i take a few though i don't know why. I take about 2-3 pills in increments of a few hours. So total i end up taking like 7ish pills. and then i throw up several times after i come down.
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    #65
    Bluelighter cdubb's Avatar
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    wow...96 pills???........
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    #66
    Grapefruit juice inhibits Pgp possibly making more cross the BBB.
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    #67
    fortunatly loperamide pills are really tiny so it's not a big deal. I can 70 robogels no-prob.
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    #68
    Bluelight Crew Beenhead's Avatar
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    I woke up today in some withdraw, and my methadone did not arrive like it was supposed too. I really realldy did not want to have to do this, but I caved, I ahd homework due. I took around 90mg of Loperamide, at ~12:30. At that time I was shaking, cold/hot, mind racing, restless legs, now, I feel 110% with a bit of a buzz.

    Now, I still am not completely satisfied this is safe. I actually can say if the 'buzz' which is very lite, is from access to the brain or just the relief.
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    #69
    Quote Originally Posted by Beenhead
    I woke up today in some withdraw, and my methadone did not arrive like it was supposed too. I really realldy did not want to have to do this, but I caved, I ahd homework due. I took around 90mg of Loperamide, at ~12:30. At that time I was shaking, cold/hot, mind racing, restless legs, now, I feel 110% with a bit of a buzz.

    Now, I still am not completely satisfied this is safe. I actually can say if the 'buzz' which is very lite, is from access to the brain or just the relief.
    Good, thats my main point that I want people to realize, that loperamide will get rid of wd's completely at a high enough dose. It is a lifesaver when you are out of drugs.

    Quote Originally Posted by ClubbinGuido
    I bet you shit iron pellets and sparks fly out of your ass from all that Lopermide.
    Nope, all plumbing working normally.
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    New member, not to be confused with a n00b 
    #70
    Hey guys! I'm new to posting, though I've been bluelighting inintrusivley until I started checking into more easily accessible means of changing my perceptions and decided that after several years and much experience I should try to contribute what I can. I've been actively researching pharmacology and psychokinetics for a long time now using collective information from several resources. I intend to become a socio-psychologist... Or something similar. It's nice to finally be a part of a community like this!

    Okay onto business:

    I fully believe that enough Loperamide was indeed able to produce a high- especially in such a high amount. Some people have their own special internal "potentiation". I'm speaking of this as loosely as a "lack of tollerance" all the way to some birth defect that gave you special receptors. I believe it's fully possible, especially in high doses. This is also dependent on administration. If loperamide was water soluble and could be absorbed in the mucosa of one's nose, than it may save you the trouble of having to use so much. I don't know too many of the properties of loperamide that would help potentiate it or improve conditions for it to cross the blood brain barrier, but there are infinite possibilities out there. My example was ritalin. I've had many experiences with stims... But ritalin did something special when I administered it a certain way with a certain *High content* (Time released- but function defeated) preparation it was excessively effective. This was reported true with injecting- That helps methylphenadate cross much faster. However, this was not the method I used! I took it intra nasally... And it worked like the regular, low content (non time released) preperations worked. Why wouldn't the same hold true for Loperamide?! I'm going to give this a try. There may be a synthesis of some sort in order here, provided I learn about its' chemical structure. Has anyone reverse engeneered it? Atleast converted it into a prodrug? I don't know. More is on the way, for sure. And I hope you keep me updated on your experience with Loperamide! If you could provide a comparison based on a typical opiate scale (For example codine (kinda' high), hydrocodon (High)/Oxycodone (High) *It's different for some, and heroin (nodding off without a doubt... likley drooling high). Give a comparison to something if you would... Poppy tea is extremely variable... I've found out the mgs of codine and morphine in a typical 500mg extraction from typical grocery seeds and the results look like a buzz similiar to but likley less than codeine. If that's what your tea is like, is that what this lorperimide is doing for you, too?

    Keep me posted man. I like where your heading- You go out of your way to try something new. Sometimes it's crazy but you give the report and go where few to none have gone. Gotta' admire that.

    Nice to meet you guys! Keep it euphoric!


    Oh and to add, I experience the very very high level opiate effects on tramodol. Like, definite nodding- I caught my blanket on fire with a ciggarette and stopped taking it! But I've also experienced the true high level addictive opiates.... They produce a more desirable high. I get the good opiate feel on trams but it's deafened by a severe tiredness when not moving around. If this is the experience for you too with trams, maybe I'll have an experience like yours on Lorperimide.

    I'm doing my research and joining your cause!
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    #71
    Quote Originally Posted by Euphorification
    If you could provide a comparison based on a typical opiate scale (For example codine (kinda' high), hydrocodon (High)/Oxycodone (High) *It's different for some, and heroin (nodding off without a doubt... likley drooling high). Give a comparison to something if you would... Poppy tea is extremely variable... I've found out the mgs of codine and morphine in a typical 500mg extraction from typical grocery seeds and the results look like a buzz similiar to but likley less than codeine. If that's what your tea is like, is that what this lorperimide is doing for you, too?
    Hmmm... ok. I'm not 'barely high' or 'kinda high'. I'm not 'basically high', or 'somewhat high'. I'm 'holy shit, I'm actually high' high. Imagine that you had no tolerance and you took a 7 mg vicodin. You'd feel pretty damn good. The buzz isn't as good as vicodin of course, but you asked for a comparison. The effects are actually the most similar to morphine, in that it lasts for hours and it is difficult to sleep when coming down.

    It's not the best high in the world, but the euphoria is there and it's intense and it lasts all day. Here's an analogy - It's not a Maserati, but it'll definitely qualify as a Toyota Prius.

    I caught my blanket on fire with a ciggarette and stopped taking it!
    I've done that a couple of times while lying in bed, winding down after a poppy seed tea binge. Once the cigarette burned down to my hand and scorched the shit out of my fingers.
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    #72
    Bluelighter lyXw33d's Avatar
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    Thanks to lope I now can basically skip w/d's -- just 3 days of feeling tired (but not weak hallelujah) and a bit of a bad mood. Who would have thought (no one outside of the internet believes me though haha).
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    #73
    they say that any of the chemical that crosses the BBB, gets vanished within seconds... he could be right, maybe u got high on the face that u werent withdrawling anymre lol, ya never know...but if u were to get high it wouldnt be that long in my opinion or research
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    #74
    ^^

    Quote Originally Posted by malfunkshun
    Hmmm... ok. I'm not 'barely high' or 'kinda high'. I'm not 'basically high', or 'somewhat high'. I'm 'holy shit, I'm actually high' high. Imagine that you had no tolerance and you took a 7 mg vicodin. You'd feel pretty damn good. The buzz isn't as good as vicodin of course, but you asked for a comparison. The effects are actually the most similar to morphine, in that it lasts for hours and it is difficult to sleep when coming down.
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    #75
    the length of time that you're high does not necessarily have anything to do with how long the chemical is physically in your brain
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