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Thread: Offsite Studies & Where can YOU, as a member, offer yourself for a study?

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    #26
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    Quote Originally Posted by Paulymorphone View Post
    ...but in California
    lol, UCLA actually has a number of neuro projects related to what you're interested in OP. Wanna come out to cali? who doesn't Tronica and the post above her's, I think, hit the needle, pun intended, on the head here imho.

    Seek (professional ideally) help + get some time away from your DOC/drugs generally = the ticket to stability and harmonious bliss
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    #27
    Bluelighter SinisterMuffin's Avatar
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    I am most interested in studies regarding the use of MDMA to help those diagnosed with disorders like manic depression and PTSD, as I have been with both. I also suffer suicidal tendencies, fibromyalgia, and terrible insomnia which I think are all closely related to the PTSD and manic depression/bipolar disorder. While most of my experiences with MDMA (or 'ecstasy') have been for fun, there have been times where I ingested it and became extremely introspective and tried to sort through some of my life difficulties. I think participating in therapy enhanced by MDMA would be greatly beneficial to me in helping me work through all of my deep-seated issues. I think that if I were able to gain a new perspective and work through things while on MDMA, that I could face my day-to-day life much more easily, and perhaps even be "cured" (of sorts) like onthemend. I think since all of my conditions are related, that to be able to work through my underlying issues and come to an understanding with them (instead of constantly dwelling on them and all of the negatives my life) would ultimately lessen the effects or possibly even erase the bulk of my disorders.

    Perhaps I am completely incorrect in thinking this, but I am willing to try. Conventional methods (medications, antidepressants, counseling, sessions with psychiatrists, etc) have yet to have much of an impact on improving my life. I know a lot of it is mental, and am not expecting a miracle, but I know that MDMA has a way of making me see things more clearly. It allows me to look at things in my life more objectively, as if they aren't my own problems, and therefore makes me able to see past those issues or a way through them... so using that along with counseling or therapy or something similar seems greatly beneficial to me. Perhaps I would no longer feel the need to use MDMA or other substances if I were able to reach such long-lasting mental clarity like onthemend has. If need be, I am even willing to travel wherever I am needed to participate in such a study. Even if my PTSD does not stem from war, it is still a serious condition that has held me back for the majority (16 years) of my short life (23 years). I want to be ale to enjoy my life rather than mourn it. I'd like to be a productive, functioning member of society. I'd like to make my family proud, and to one day have one of my own. But as much as I want all of these things, I am not sure I can do it on my own...

    So, there you have it. While I would prefer a study centered around the use of MDMA as a therapeutic tool, if there is any study in regards to the above, I am willing to consider the possibilities. I would be honored if approached.
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    #28
    I have taken over 1000 ecstasy pills over a 19 year period. In the first year I had one or two weekends of no e and in the following years I caned it for around 4-5 years. Since then I have taken it regularly but not abused it. I would be happy to be studied!
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    There's a drug study in my area coming up, I was wondering what to expect if I join 
    #29
    Bluelighter llamer's Avatar
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    I don't like med studies, being confined, all that shit. But this pays alright.

    They dose you with meth on day 1 or 2, and keep you loaded with wellbutrin and nalaxone for 12 days total. on day 10 the hit you with another blast of meth.

    Just wondering if this sounds sketchy at all. I'm not really worried, but normally when I get high I like to take hella benzos to curb my depression on the comedown. I sincerely DOUBT that these other pharms will do that.

    But I'm also wondering if you guys think 30mg racemic methamphetamine IV would be considered too intense a dose. I've smoked it and snorted it, but it's not like I ever weighed it out before hand. I think I'd be able to handle it (I've done it only a few times), but how much would you say it differs from 2 big rips off some high quality crank? last time I did that I was high as fuck and it wasn't so bad, just the comedown blew and I like to sleep like the rest of all animals.

    OFF TOPIC? I dunno, thanks to anyeone if they share a thought or two
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    #30
    Bluelight Crew PepperSocks's Avatar
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    Sort of off-topic as this forum is for the posting of actual studies (ongoing or completed) and not for chit-chat about the latest newspaper article, etc.

    However, I can see merit in a thread like this to discuss what to expect when you participate in a study; especially if it involves the use of active substances. [Other mods voice your thoughts]

    As for your substance related question; that's more an Other Drugs specialty, but I'll take a stab nonetheless. I haven't done the IV thing or meth thing but I have done proper weighed doses of pure racemic amphetamine, dextro amphetamine (oral, sublinual, and nasal). 30mg is definitely a strong dose for a non-tolerant user and will produce a signifigant high, but it shouldn't be dangerous under normal circumstances. I would expect the IV and vaporization routes to produce similar onset times so take that into account. I would imagine 30mg of IV methamphetamine to be strong but with your previous use it should be manageable (or enjoyable :P).

    I'm not sure about the interactions of wellbutrin, naloxone, and methamphetamine. By the looks of it, that would be my primary cause for concern (day 10). They may provide a benzo on the comedown and they may not; you'll have to ask them (ask them a lot of things, you're the guinea pig).

    Also make sure you read the entire procedure, all that it entails, and that they have verified ethics approval. This sounds a mite sketchy but possible with the proper safeguards. Do your research and exercise your right to ask a million questions.
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    Adderall/vyvanse high dose 60mg 10 years+ up for study 
    #31
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    ive been perscribed vyvanse and adderall interchangably since the 3rd grade and i am a senior now, and would really like to be apart of a study and am curious how i could go about doing so.
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    #32
    Bluelight Crew PepperSocks's Avatar
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    There have been a few ADHD/stimulant survey studies come through this forum; I suggest you use the 'advanced search' feature.

    Also check out http://www.clinicaltrials.gov ; they are a database that lists many drug studies internationally.
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    #33
    Greenlighter SjDrS7926's Avatar
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    WOW i have to wish u all luck.. and that u all if u havent already gets the awnsers u need and the relief that u deserve....
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    #34
    Bluelighter OTGee's Avatar
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    If anyone wants to do a study on synthetic cannabinoids

    I have recieved permenant GI Discomfort from overdoses / moderate - heavy use. My throat / chin / neck area also feels weird and tight and it is very uncomftorable sometimes.
    My fiancee has had severe migranes, anxiety disorders, severe tinnitus and smoking cannabis now makes her feel weird (unlike any high she has ever experienced she says) and smoking cannabis usually just results in more panic attacks anyway now for her so she has taken a break to see if it might get better. Recently her anxiety has improved a bit and so has the tinnitus since taking natural suppliments but it is still prominent. It has become some what bareable she says but before she was talking about ending her own life. This was all from a one off overdose, she never used them again after.

    Sometimes we both get flashbacks to overdoses that feel horrible, I have OD'ed on am-2201 before and it was nothing like what we experienced after a supposed am-2201/2233 blend that is 20x as worse, the overdoses are worse then hell its self and the withdrawals were a bitch as well. We both just feel 'different' or 'weird' since then and its not just us creating a placebo effect. Sometimes I get precise pangs of pain that I cannot describe, its not in a part of my body, just a twang of pain (That sounds insane I know) but this is infreqeuent. My negatives are nothing compared to my fiancee's and it eats me up in side that I may have ruined her what was once daily, lovely relationship with cannabis and caused so many things that make it hard for her to live her day to day life as it was me who encouraged her to smoke the synthetics.
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    #35
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    Quote Originally Posted by YourLiege View Post
    Alcohol and it's weird affect on me

    This had not happened until the past 6-8months.

    Everytime I consume any alcoholic beverage now, I feel an IMMEDIATE sick feeling. Malaise, Dehydration, headache, soreness, weakness, energy loss. I mean, IMMEDIATE. I don't know why now it does that to me, but it never happened in the previous 12 or so years I've had a drink...or many. Last summer I was bartending and could drink during, before and after work. I did drink heavily for the 3 months of the summer and then I stopped drinking so heavily. Just 2x a week or so. But for a while now, I get that reaction in my body to ANY alcoholic beverage and don't know why.

    I know Alcohol is supposed to dehydrate you, etc but, it's really weird how it affects me now. Thoughts????


    -YLLC
    If the alcohol is made with wheat, could be a gluten issue. I know alot of people live for years with gluten allergies and dont even know, so maybe you have just reached the point that it is showing effects now.
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    #36
    Director of Research Tronica's Avatar
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    Quote Originally Posted by OTGee View Post
    If anyone wants to do a study on synthetic cannabinoids

    I have recieved permenant GI Discomfort from overdoses / moderate - heavy use. My throat / chin / neck area also feels weird and tight and it is very uncomftorable sometimes.
    My fiancee has had severe migranes, anxiety disorders, severe tinnitus and smoking cannabis now makes her feel weird (unlike any high she has ever experienced she says) and smoking cannabis usually just results in more panic attacks anyway now for her so she has taken a break to see if it might get better. Recently her anxiety has improved a bit and so has the tinnitus since taking natural suppliments but it is still prominent. It has become some what bareable she says but before she was talking about ending her own life. This was all from a one off overdose, she never used them again after.

    Sometimes we both get flashbacks to overdoses that feel horrible, I have OD'ed on am-2201 before and it was nothing like what we experienced after a supposed am-2201/2233 blend that is 20x as worse, the overdoses are worse then hell its self and the withdrawals were a bitch as well. We both just feel 'different' or 'weird' since then and its not just us creating a placebo effect. Sometimes I get precise pangs of pain that I cannot describe, its not in a part of my body, just a twang of pain (That sounds insane I know) but this is infreqeuent. My negatives are nothing compared to my fiancee's and it eats me up in side that I may have ruined her what was once daily, lovely relationship with cannabis and caused so many things that make it hard for her to live her day to day life as it was me who encouraged her to smoke the synthetics.
    Hi OTGee... I am doing research on synthetic cannabinoids in Australia. I've done a literature review recently and there are other cases of GI problems which have been linked to synthetic cannabinoid use. There are also some pharmacological reasons why we would expect synthetic cannabinoids to be more harmful than cannabis although more research is needed.

    Are you able to access any treatment?
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    #37
    What about people with epilepsy?
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    MDPV in the midwest 
    #38
    Greenlighter piecewise.da's Avatar
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    Would love to participate in a study of MDPV or its close relatives. I was a daily MDPV user for 9 months before the DEA ban. I handle it well, no anxiety, can control re-dosing compulsions. However, when I am unconscious and have MDPV in my system I will constantly kick my legs and talk or yell insane and horrible things. What has been described to me sounds like I am running in place while reliving childhood sexuall abuse from the vantage point of my abuser. I have a lot of issues that preclude me from mainstream drug studies. I smoke cigarettes, take opiates for back and leg pain, and psych meds for PTSD and Bipolar Type 1 w/ psychotic features. But if your study is near Kansas City and you want me, drop me a line.
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    #39
    Bluelighter d-kong's Avatar
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    i am a willing participant for clinical trials with new medications...especially if they have anything related in any sort of thing that may cause psychedelic reactions but also may be used to help with other situations. anyways...im definitely a willing participant. i've always been interested in such a thing...(I'll eat the brownie lol)
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    #40
    I have what I think is a unique experience:

    I am 36 years old and have used DXM in almost every day use since the age of 25. I am a software engineer and a family man that has been able to not only keep my job and social status, but have also improved my career and family situation. The only negatives I've found from using almost daily 3rd plateau doses is annoying sweating and some memory loss (stuff like peoples names, which do come back, they just take longer to remember). When I find myself having more negative effects, I quit for a few days and seem to come back to normal. Most euphoric effects have left me, except for 1k+ mg doses, but since I'm addicted, I still find it somewhat worthwhile for the anti-depressant effects at lower dosages. I did quit for about a year, but I'm pretty much stuck as a self medicating dxm user for now, until I can either swap it out or find something that can switch my brain off to the need to get high. People, don't follow my lead, I'm obviously a freak.
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    #41
    case study on aripiprazole, valproate, olanzapine treatment, compliance, and recreational drug interactions from a patient point of view (bipolar I diagnosis)

    Subject : male (me), 31 years.

    The first episode in life being major depressive for 6 months without treatment, starting during first college year in France at Paris VI (who on earth can not be depressed by pacing in this architectural asbestos laden nightmare campus, seriously ! ) escalating to a moderate/severe depressive episode requiring 150 mg venlafaxine daily (3 * 50 mg divided in the day, XR was not available in France at this time).

    Diagnosis : unipolar depression

    Revised diagnosis : bipolar I, current episode depressive

    2002 Was a turning point since it was the year (in december, 7 2002) of a first mixed episode with psychotic/delusional features triggered by a burnout work condition (worked already as an IT engineer, self-educated by absorbing thousands of IT network admin books), receding into depression since olanzapine 2*10mg + 3* 20 mg prazepam were added and venlafaxine withdrawn (the olanzapine antidpressant effect being to weak to compensate the venlafaxine withdrawal and resultant depression)

    The 2002-2008 period has seen a compensated phase without any kind of official treatment,guidance, and compliance, but including substance abuse (weak opioids - codeine) as a coping mechanism. This was later switched to buprenorphine (self-medicated) for it's emotional/blunt affect properties and antidepressive properties (based on high baseline reward and euphoria) rather than SSRI stimulation. dosage was 0.3 mg daily, which is low and at the border between pain relief dosage and opiate dependance maintenance dosage.

    Recreational use of other substances included cannabinoids (some experiences creating a decompensation potential for a mixed state)
    benzodiazepines (long half life bromazepam to a dosage of 18 to 24 mg per day at peak usage, in a 2 week acute use/ 2 week abstinence patttern. Physical BZD withdrawals symptoms were never observed)

    No further professional diagnosis were made.

    2008 Has seen an hypomanic phase during 1 month triggered by positive affective events reinforced by buprenorphine withdrawal, creating a sensory; affective, cognitive overload; escalating to an acute manic phase : psychotic/delusional persecutive and "impeding doom" ideation. These elements where non congruent with the manic phase, but too short lived to call it a "mixed state" At this time the diagnosis of bipolar I was officially done. the manic phase was treated with olanzapine 10 mg/day + 20 mg very weak BZD (prazepam)

    Since 2008, my compensation mechanisms have greatly increased since it did not require any hospital commitment (commitment by request of a third party in 2002, commitment by choice in 200 The treatment consisting of valproate 2*500mg and aripiprazole 20mg decreased over 3 years to 5 mg.

    sometimes, aripiprazole is discontinued for 2 weeks to reduce the plasma concentration and during treatment the dosage strategy is a completely day by day tuned dosage (sometimes 5, sometimes, 10 mg, sometimes 20 mg) in order to explore the dose response stimulation/sedation curve of aripiprazole.

    Cocaine hydrocloride and cocaine base (inhaled) were shown to have a diminished reward and euphoric effect during the 2009-2011 time line. probabbly because of the dopamine receptors blockade by aripiprazole and natural tolerance creating a dampening effect. runaway cocaine occured for the first 5 months with a peak use of 1g every 3 days, to a low of 1g every 3 weeks. slight depression symptoms emerged and were treated with venlafaxine 75mg XR. cocaine use decreased in 2011 Q4 and 2012 Q1

    later, Venlafaxine was introduced at a range of 37.5 to 75 mg, dose-modulated each month by self-assessment and doctor guidance.

    feb. 2012 has seen a protracted and incomplete burnout syndrome managed entirely with rest caused by acute use of ethylphenidate and intensive night work for the end of 2011 (3 weeks of 100+ hours of work/week, mainly IT cognitive intensive tasks)

    I will update soon. take care !
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    #42
    Bluelighter P A's Avatar
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    But I'm also wondering if you guys think 30mg racemic methamphetamine IV would be considered too intense a dose.
    Honestly, if I were one of the researchers, I would be very concerned about the ethical implications of their study. I mean, no antioxidants or anything in combination with a high-dose IV neurotoxin? I mean, jesus harold christ. There's no way that even half of the participants of this study could appreciate the neurological risk that it entails.

    If I were you, I would go through with the study, but consider administering a ton of antioxidants beforehand. If you must deceive them, do so. The health of your striatal neurons is far more important than the integrity of their data. I recommend liberal doses of acetylcarnitine, CoQ10, and acetylcysteine prior to and a few days after the meth. The first two are highly unlikely to interfere with the results of their study, if I correctly understand their reasons for conducting it.
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    #43
    A ton of antioxidants is pretty vague. A "ton" of Ascorbic Acid (10 000 mg) is pro-oxidant in my understanding. I wouldn't take this study, especially since it's racemic meth. 15mg of l-Methamphetamine IV sounds unpleasant to say the least.

    But yeah, pretty unethical study in my view, IV meth certainly is pretty unhealthy. I wonder why they didn't choose dextrorotatory and just lower the dose or something, perhaps they want to make it kinda unpleasant so they don't turn people into meth addicts.
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    #44
    Quote Originally Posted by P A View Post
    Honestly, if I were one of the researchers, I would be very concerned about the ethical implications of their study. I mean, no antioxidants or anything in combination with a high-dose IV neurotoxin? I mean, jesus harold christ. There's no way that even half of the participants of this study could appreciate the neurological risk that it entails.

    If I were you, I would go through with the study, but consider administering a ton of antioxidants beforehand. If you must deceive them, do so. The health of your striatal neurons is far more important than the integrity of their data. I recommend liberal doses of acetylcarnitine, CoQ10, and acetylcysteine prior to and a few days after the meth. The first two are highly unlikely to interfere with the results of their study, if I correctly understand their reasons for conducting it.
    To the researchers, they just think "They signed the paper, we can't get sued, lets screw up some people's bodies!", considering most people who do drug trials for money probably don't know much about the drug they're testing or the paper they're signing at all.
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    #45
    Bluelight Crew PepperSocks's Avatar
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    Quote Originally Posted by P A View Post
    If I were you, I would go through with the study, but consider administering a ton of antioxidants beforehand.
    Agreed, within reasonable quantities. Every day: Standard multi-vitamin (with good amounts of B's in there), vitamin E, up to 2000mg of vitamin C, Magnesium, 5-HTP/melatonin at night.

    Read up on a good anti-oxidant regimen and ask the researchers if you can take it. If they say you can't take vitamin C or E, that would raise a red flag IMO.
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    #46
    Yeah, that's a pretty good vitamin regimen. Probably good for everyday in general. I usually take 1000mg Vitamin C + Multivitamin + 200mg Magnesium + 1500mg lethicin
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    #47
    Greenlighter bunni's Avatar
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    i just got out of the military and have had sooo many issues since i joined, panic, anxiety, depression and severe back pain, PTSD, anger and all types of stuff.. i would love to test for pain and any like benzo type things, sedatives etc... im in california so if anyone needs a 'guinea pig' or test subject let me know if you need me!
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    #48
    Greenlighter soniclady's Avatar
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    any researchers etc needing input from some one who has been diagnose clinicly depressed at 20 with other illness have used mdma,mdai,mpa,5-meo-dalt,mxe,ket,3-meo-pcp ,kratom, magic mushrooms not all at once but some in combination still here to tell the story and enjoyed every minute

    happy to share info or add input to lagit research
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    #49
    Not sure if this is what this thread is exactly aimed at but I have something that I have always been curious on. My produces fructose (albeit small amounts). I am one of about 5 known people in the world to have this. Curious as to what sort of affect (if any) this would have on certain drug interactions. When I was little a top researcher from Chicago came to investigate my case. I am no longer in contacts with my parents and just know this because I asked once a few years back to provide me with my medical history. Again, sorry if this is the wrong place for this. Just kinda would like to know more about it myself

    ALSO, I have a benign brain tumor in my thalmus. Again just wanting to get more info on this for me personally so if anyone is looking to use me as a guinea pig or wishes to know, I would be glad to have a conversation
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    #50
    Bluelight Crew PepperSocks's Avatar
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    ^ It's 10 days late but if you see this; check out clininaltrials.gov they have a database of studies all over the world. Although this doesn't necessarily pertain to our forum; as it's centered around recreational drug use, and not general health, but do keep close watch on your health. A benign tumour in a place like that isn't something to forget about, I would still get scans done at certain intervals to make sure it doesn't grow and start pressing on things.
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