Alright, my doctor prescribed me Celebrex today for my shoulder and I was wondering if I could take 200mg of Codeine about 5 hours after my Celebrex dose.
I used an Interactions checker and it said there was a moderate interaction but it gave the information in terms that I'm unable to understand.
What I got from this: You can take these two together without any health problems at all, but the Celebrex will make the Codeine weaker.MONITOR: Drugs that are inhibitors of CYP450 2D6 may interfere with the analgesic effect of codeine. The mechanism is decreased in vivo conversion of codeine to morphine, a metabolic reaction mediated by CYP450 2D6.
MANAGEMENT: The possibility of reduced or inadequate pain relief should be considered in patients receiving codeine with drugs that inhibit CYP450 2D6. An increase in the codeine dosage or a different analgesic agent may be necessary in patients requiring therapy with CYP450 2D6 inhibitors.
Am I right, or am I completely wrong?
I bassically want to know if taking 200mg of codeine about 5-6 hours after a Celebrex dose will have any health problems, and if it would be OK?