Hey everyone I am wondering if people have any knowledge about these too drugs and there interaction. some web site has a fallowing it seems that, says they live and die by the belief that The saint Johns wart potentiates the shit outa Bupe to the point they dont take it any more without it.
Odd things I read in this forum was they were taking high dose suboxone I E 4-8 mg and still getting a great responce from this combo. which doesnt make sence to me cuz most the people who this forum that get a good effect w/o use of benzos are using low does bupe I E 4 mg or less but more so 2 mg or less per day...
some of the folks say it is something that works better and better the more days u do this combo which if true would be great. theres just so litttle info on the topic im makeing this thread to hopfully get more on it in one place
I guess the reason why its ment to work is it inhibits the same liver enzyme cimitidine does(CYP3A4)t also induces a liver enzyme CYP3A4 (this is the enzyme that is ment to make bupe into NOR bupe.
my understanding is that would b keeping more Bupe around in ur body but also create a higher turn over of that bupe into nor bupe which is ment to b a full agonist so this theroy sounds valid to me but i didnt really get that effect who knows tho the people in the forum that spoke on it sure sound like they did
any who I donno if this is considered sorcing but ill put it in and if it is please just let me know and i will take this paragraph out . but the website that speaks on all this is. http://forum.opiophile.org/showthread.php?t=14532
Please anyone with More knowledge on this topic feel free and explain to me what they know and what they experinced while trying this combo.
and if you dont know anything but think its a cool Idea give it a try and get back to me on how it went