My friend who gets boatloads of pills handed me a goodie bag last week with 3 medications in it: Welbutrin, Seroquil, and Asenapine. He told me to take the Asenapine for anxiety or for sleep.
I've taken them 4-5 times now and the first 3 times it had me nodding within 5-10 minutes. I've found if you fight the sleepyness it gives you a semi-recreational euphoria that is comparable to ambien or sonata.
The past few times, however, I've taken them right at bedtime, and it's given me a wicked boost of energy like I've just done some coke, along with akathisia, which is just a general sense of restlessness and unease.
The pharmacology from wikipedia:
"Asenapine shows high affinity (pKi) for numerous receptors, including the serotonin 5-HT1A (8.6), 5-HT1B (8.4), 5-HT2A (10.2), 5-HT2B (9.8, 5-HT2C (10.5), 5-HT5A (8.8, 5-HT6 (9.5), and 5-HT7 (9.9) receptors, the adrenergic α1 (8.9), α2A (8.9), α2B (9.5), and α2C (8.9) receptors, the dopamine D1 (8.9), D2 (8.9), D3 (9.4), and D4 (9.0) receptors, and the histamine H1 (9.0) and H2 (8.2) receptors. It has much lower affinity (pKi < 5) for the muscarinic acetylcholine receptors. Asenapine behaves as a partial agonist at all receptors. As of November 2010 Asenapine is also in clinical trials at UC Irvine to treat stuttering."
anyone had experience with this?