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Thread: Plugging (rectal) doxylamine (unisom) for insomnia?

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    Plugging (rectal) doxylamine (unisom) for insomnia? 
    #1
    Anyone know the bioavailabilities of doxylamine? Specifically... orally, rectally, intranasally, etc. I am having terrible insomnia and do not want to insuffilate anything and am hoping plugging doxy will achieve a similarly high BA as intranasal does.

    From what I've heard on here... oral is around 20-25% and nasal is around 70% i'd assume plugging would be even higher...maybe 80-90%? anyone know and is there any safety issues with plugging a low dose (< 5mg) of this antihistamine?

    Is it possible to make a solution of h2o and doxy and use it intranasally as a liquid to avoid any potential damage to the nasal lining and lungs from insuffilating powders?
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    #2
    you low on unisom pills? in this case, you might want to just swallow more.
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    #3
    Bluelighter
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    internasal 70.4% and 24.7% oral.

    source
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    #4
    ^just for the record, that's rats.

    +1 to hydroazuanacaine's post
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    #5
    Quote Originally Posted by hydroazuanacaine View Post
    you low on unisom pills? in this case, you might want to just swallow more.
    i have a lot...and that's not the problem...swallowing takes too long for the drowsiness to hit (30-40 minutes)... i'm looking for a very quick (under 5 mins) sedation similar to insuffilation...is there any danger in plugging 2-5mg of doxylamine? i know plugging can offer a much faster onset in the action of a lot of drugs...
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    #6
    For anyone who stumbles across this, anecdata:

    Averaged estimates.
    Very experienced with therapeutic doses of doxylamine although I don't use it frequently so I don't consider myself to have much of a tolerance.
    Very experienced with rectal administration/the drug isn't getting lost anywhere.
    I've experimented with the doses; these get me to comparable levels, although the specific effects vary.
    Nasal administration via filtered liquid solution.

    Oral
    Dose (standard to one 25mg pill, oral): 25mg
    Duration to peak: 1.5h
    Duration: 14h
    Effects: Strong anticholinergic, most physically sedating, best quality sleep. Significant delay if taken with food.
    Hangover: Moderate

    Nasal
    Dose (standard to one 25mg pill, oral): 8mg
    Duration to peak: 0.5h
    Duration: 8h
    Effects: Nearly matches oral in terms of efficacy with less cloudiness the next day. Irritating to nasal mucosa. Less allergy-related effects.
    Hangover: Minimal

    Rectal
    Dose (standard to one 25mg pill, oral): 15mg
    Duration to peak: 0.75h
    Duration: 6h
    Effects: Induces drowsiness with significantly less physical sedation. Doesn't keep me asleep as well (although this usually isn't a problem for me).
    Hangover: Minimal

    Does this sound like varying levels of absorption? Part of me wants to believe plugging is always more effective than insufflation.
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    #7
    Bluelighter ErgicMergic's Avatar
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    Quote Originally Posted by enoughorangejuice? View Post
    i have a lot...and that's not the problem...swallowing takes too long for the drowsiness to hit (30-40 minutes)... i'm looking for a very quick (under 5 mins) sedation similar to insuffilation...is there any danger in plugging 2-5mg of doxylamine? i know plugging can offer a much faster onset in the action of a lot of drugs...
    Why do you want such a quick onset of sedation? The problem with plugging is that the effects will wear off quicker, leaving you not enough sedation for a full, 8 hours of sleep. I find that a decent dose of Doxylamine (12.5mg for me) taken orally lets me sleep for 7-8 hours with no lingering hangover. I think the duration of effects is perfect as it is.

    I have thought about plugging LSD for the same reasons as you are thinking, however. I think it will take on more of a psilocybin duration (6 hours or so) when LSD is plugged, not sure how to dissolve a blotter properly, though.
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