Mods feel free to move this about to an appropriate forum.
I have tried almost all SSRI's and SNRI's along with therapy ect...
My depression is of the constant relentless variety that leaves me unmotivated to much at all apart from the essentials.
My mother I believe suffered from much the same condition although her treatment was good old fashioned booze.
100 years ago before the Harrision Taxation act took place in the states pretty much all forms of strong opiods and amphetimines were available as tonics ect..
In the 50's opiods and amphetimines were used as treatment for depression.
I myself and many others I know have tried all the avenues with modern antidepressants mostly to no effect which brings me back to the living 100 years or so ago scenario.
I've found that opiods, really are the best antidepressant there is. Addictive yes. But when you compare the widthdrawal profile against meds such as side effexor and othersand lets not forget Benzo's I really think I would trade my ipod and big screen TV to live in a period where these treatments were standard.
Beggining to rant but Australia is really becoming a hidious nanny state and I just wish, as a 30 year old adult I should have the right to choose opiods over the standard mostly useless modern meds.
If you know the risks and are prepared to make an informed decision to be (addicted) or use opiods as depression treatment for ever, then you should be able to make that choice.
I'd trade most of my mod cons for that.