There is a TON of conflicting information regarding the alleged interaction between Tramadol and Methadone; it seems that every idiot wants to come on the Internet and chime in with their 2 cents.
Some sources say that tramadol displaces methadone at the receptor.
Some sources say that tramadol induces an enzyme which metabolizes methadone very rapidly, and diminishes effects.
Some sources say that mixing the two will provoke a lethal pharmacological interaction (as in, more lethal than mixing tramadol with any other opiate).
It is easy to imagine that these claims could have just been mere rumors that resulted when someone misinterpreted what someone else said. For example, someone might have read "Don't take tramadol if you're on methadone, because it blocks it" (meaning tramadol can't break through a methadone tolerance) as "Don't mix tramadol and methadone!!1 Tramadol blocks methadone!"
Then there are others who dismiss all these claims as the bullshit they most likely are. But who knows? The Internet is becoming an increasingly erroneous source of information (especially regarding drugs), and the Adv. Drug Disc. section of bluelight seems to be one of the last safe havens from these morons flocking to their computers.
Thanks for any response.