Okay I know we have an addiction and tolerance thread here but I wanted to ask this question. Since NMDA blockade seems to prevent a lot of the anxiety and seizures of withdrawal, would NMDA antagonists (memantine and dextromethorphan polisterex, due to their long action) be feasible replacements for GABAergic medications like alprazolam, clonazepam, and diazepam?
I know that AMPA is involved as well but I don't really see why stand alone NMDA blockade wouldn't help a lot of people without the intense side effects of SSRIs and similiar drugs. Obviously in the case of DXM caution is needed with certain drugs (serotonin releasers) but memantine doesn't pose that issue and the side effects between the two are much more manageable than medications that make specific targets for serotonin and/or norepinephrine.
The reason that I ask about this is because I just started an NMDA antagonism job to kick Clonazepam once and for all. Well I was up all night and my dose was due at noon and I forgot to take it before I passed out. Obviously I woke up about 4 1/2 hours later with rebound clonazepam anxiety. I was in almost full-blown panic but took my clonazepam and Delsym together. 1mg clonazepam, 15mL Delsym. About 20 minutes later the panic turned to a very stern calming effect and now I feel fine even though I know that for me, clonazepam takes at least an hour and a half to take full effect and usually about around an hour and twenty minutes I would start calming down.
I have been wondering about the GABA - NMDA model for awhile now and it stands to reason (in my mind) that long-term NMDA antagonists could be quite beneficial for anxiety and would be far safer than GABA agonists. Comments? Theories? I never really thought about it but whenever I was using DXM in high doses daily I never had ANY anxiety, even with the tachycardia and other signs of distress in the body. I would think that this would also give the body a break on cortisol release and maybe replenish its own adrenaline stores again. That last one is just a guess though as I'm thinking that may be a possible downside - the body may stop making adrenaline since the brain would be tricked by the excess GABA to think that everything is okay even when it is not. At the same time though I'd rather have that over panic attacks.