The cannabinoids are scary. This is coming from someone all too well acquainted with psychosis (both genetic and substance induced).
Weed/pot/MJ/etc is no joke. That plant is a powerhouse and commands respect. If something is wrong in your kingdom, then smoking weed will lead you to the issues at hand.
Hydro is a different beast altogether, but then those synthetics.... fuck...
It's the classic tale of nature providing just what's needed, then human being finds a way to ramp it up for kicks, then science finds a way to make it a nightmare. The further you get from the source, the more twisted shit gets.