Bluelight

Thread: The Big & Bangin' Miscellaneous Chemistry/Pharmacology Odds N' Ends Thread: Part 3

Page 2 of 3 FirstFirst 123 LastLast
Results 26 to 50 of 62
  1. Collapse Details
     
    #26
    Bluelighter neurotic's Avatar
    Join Date
    Dec 2011
    Location
    intravenous
    Posts
    1,591
    Getting a proper mg scale is not exactly ridiculously simple for me actually.

    I'm in a third world country and the best I can get locally is either a high-end piece from a labware store costing roughly the price of a popular car or an AWS-100, a centigram scale, for an insultingly inflated price. Granted the latter would suffice for compounds such as 4-FA, but I'd rather have a more precise and fairly priced piece suitable for any chemical I might stumble onto: I do intend to buy, say, a GEMINI-20 off of Amazon in the relatively near future, just have to figure out how international stuff works there. I see the irony, but in the meantime... and in any case none of the options above are a hassle for me.
    Reply With Quote
     

  2. Collapse Details
     
    #27
    Quote Originally Posted by neurotic View Post
    I am interested in the long-term storage of chems — here, 4-FA particularly — in solutions proper for IV use. More elaborately,

    So I have a bunch of 4-FA, and without a proper scale, I am forced to go with volumetric dosing. I would gladly choose vodka were it not for the fact that my ROA is mainlining. I thought of a few workarounds and would like y'all's opinion:

    — Dissolve in a 5% alcohol solution made from vodka and water, keep in fridge. What I'm not sure here is: is it too much water? Is 5% alcohol too much to be IV'ed? — I could at least conceive slightly alcoholic pharmaceutical IV preparations.

    — Dissolve in vodka, when going to use — this is going to be un-often enough for it to not be a turn-off —, evap off vodka or most of it, replace with appropriate amount of water — 4-FA doses are big enough so that they should be visible. I'm thinking here no appreciable amount of salted 4-FA should be lost though I ask just to be sure...
    Depends on the volume of alcohol you end up IVing. If you IV less than maybe 5mL of pure ethanol, you're probably fine.
    Reply With Quote
     

  3. Collapse Details
     
    #28
    Bluelighter neurotic's Avatar
    Join Date
    Dec 2011
    Location
    intravenous
    Posts
    1,591
    Overall amount of ethanol injected should be less than that — I use 1ml syringes...

    What about the concentration however? I imagine 40% ethanol straight into the veins shouldn't be much healthy, seeing what that stuff does to the lining of your stomach...
    Reply With Quote
     

  4. Collapse Details
     
    #29
    Quote Originally Posted by neurotic View Post
    Overall amount of ethanol injected should be less than that — I use 1ml syringes...

    What about the concentration however? I imagine 40% ethanol straight into the veins shouldn't be much healthy, seeing what that stuff does to the lining of your stomach...
    Hmm, I'm not sure about concentration actually. Maybe wait for another response. I know that some benzodiazepines are administered IV in a solution of ethanol, but these are infusions over a period of time. Also, here's a study testing the efficacy of IV ethanol for alcohol-dependent patients.

    https://www.ncbi.nlm.nih.gov/pubmed/15537562
    Reply With Quote
     

  5. Collapse Details
     
    #30
    Moderator
    Neuroscience and Pharmacology Discussion
    sekio's Avatar
    Join Date
    Sep 2009
    Location
    Atreides Palace
    Posts
    18,590
    IV injection of alcohol solutions of any sort is a no-no because of their hypotonicity: needs adjustment with salt, sugar or the like to make it vein-tolerable (and these tend to decrease the solubility of organics in ethanol/water mixes!)

    For most compounds, 4FA included, dissolving in bacteriostatic water (distilled water + 1% benzyl alcohol) is more than enough, plus storage in the dark and cold between 5-10C. Esters like cocaine, heroin, methylphenidate & analogs should be kept dry and reconstituted with basteriostatic water only when they are needed, to avoiid decomposition via hydrolysis.
    Guidelines for OD ||| OD Standards ||| OD Directory Read Me First! ||| NPD Rules
    Please read the links above or PM me if I lock your post. Stay Safe. R.I.P. F28
    Reply With Quote
     

  6. Collapse Details
     
    #31
    Bluelight Crew Solipsis's Avatar
    Join Date
    Mar 2007
    Location
    NL
    Posts
    15,177
    Dammit, once again I'm trying to calibrate my mettler toledo AE-160 and it's giving me the error after I give it a 100 mg weight.

    Not sure how to proceed, I forgot how I solved it last time(s), if it was the same issue then... but I seem to recall something similar.

    I seem to be 0.1% off.
    Reply With Quote
     

  7. Collapse Details
     
    #32
    Moderator
    Neuroscience and Pharmacology Discussion
    sekio's Avatar
    Join Date
    Sep 2009
    Location
    Atreides Palace
    Posts
    18,590
    Check the batteries. Most scale bugs I've seen are due to flat batteries. And also don't breathe, have loud music going, or move while weighing/calibrating.
    Guidelines for OD ||| OD Standards ||| OD Directory Read Me First! ||| NPD Rules
    Please read the links above or PM me if I lock your post. Stay Safe. R.I.P. F28
    Reply With Quote
     

  8. Collapse Details
     
    #33


    Just saw this for sale and apparently it's a psychedelic. Anyone seen this before? I've never seen this novel sort of structure before.
    Reply With Quote
     

  9. Collapse Details
     
    #34
    Bluelight Crew Solipsis's Avatar
    Join Date
    Mar 2007
    Location
    NL
    Posts
    15,177
    Quote Originally Posted by sekio View Post
    Check the batteries. Most scale bugs I've seen are due to flat batteries. And also don't breathe, have loud music going, or move while weighing/calibrating.
    Thanks but it's AC powered, a nice classic obese sub-mg weighing piece of machinery.. Yes I realize how subtle drafts, vibrations etc can influence it - i got it nice and level on a sturdy counter top, windows closed, silence, not moving.

    Right after I give it the 100 mg weight it is asking for (CAL 100), it tries to measure and is giving me a CAL ERR, and I don't think it's because it doesn't know what to say.

    Quote Originally Posted by aced126 View Post


    Just saw this for sale and apparently it's a psychedelic. Anyone seen this before? I've never seen this novel sort of structure before.
    for the record - asked in PD and identified as U-47700.
    Reply With Quote
     

  10. Collapse Details
     
    #35
    Moderator
    Neuroscience and Pharmacology Discussion
    sekio's Avatar
    Join Date
    Sep 2009
    Location
    Atreides Palace
    Posts
    18,590
    Soli, have you tried monkeying with the integration/stability detection settings on the scale? I've gotten temperamental milligram scales working again by just adjusting the "sensitivity" a few Arbitrary Units in the right direction. And the cal weight -according to the manual - is apparently supposed to be 100 grams, not 100mg - maybe that is why you are having trouble?

    I don't think I've seen a scale that has the option for an external foot pedal either.


    aced, compounds of that sort are these curious novel opioids developed at Upjohn some time in the 80s, however many of them have more activity at the kappa receptor than is classically tolerable in an analgesic. AH7921 and U47700 are the mu-selective cmpds that the RC guys picked up. AH7921 was not anything to write home about but I'm told U47700 is much more "abusable" i.e. rapid rise in brain concentrations followin administration not unlike oxycodone or fentanyl.
    Guidelines for OD ||| OD Standards ||| OD Directory Read Me First! ||| NPD Rules
    Please read the links above or PM me if I lock your post. Stay Safe. R.I.P. F28
    Reply With Quote
     

  11. Collapse Details
     
    #36
    Bluelight Crew Solipsis's Avatar
    Join Date
    Mar 2007
    Location
    NL
    Posts
    15,177
    Oh shiet, i think you saved the day with that one.. it probably IS 100 grams that's required now that I think about it, it typically is a weight at the maximum of the range of the scale, which of course makes most sense in terms of physics / significant numbers. (Well, 'probably'.., you consulted the manual no less, what's to speculate?)

    The strange thing is, I thought I remembered successfully calibrating this thing before and I very well may have as I used to have more access to necessary items etc, and yeah I recall reading the manual myself. Furthermore the very legit russian calibrating weight set I have on hand "conveniently" stops at 50 grams (wump wump wuuump).

    Can I somehow use the 21 gram weight of my soul to calibrate? :')
    (the answer is yes, it would involve a setup where you would weigh me before and after voting on Donald Trump for experimental purposes)

    I think I don't feel like spending a lot of money on a true 100g weight, a chinese piece of shit that weighs a 100 grams will have to do, if the error on it is 3 mg then for my purposes that is probably fine wouldn't you say? I think these days the most potent substance I'd be weighing on it would be something like DOM. I'd say the scale wouldn't fuck up too much on account of the 0,003%, what do you think?

    P.S. yes I changed those settings, but in light of the above that all seems in vain.. lol i fucked up pretty good there
    Last edited by Solipsis; 13-01-2017 at 19:02.
    Reply With Quote
     

  12. Collapse Details
     
    #37
    Moderator
    Neuroscience and Pharmacology Discussion
    sekio's Avatar
    Join Date
    Sep 2009
    Location
    Atreides Palace
    Posts
    18,590
    Soli, if you're up for it, you can send me a PM with some shipping details and I'll send you a calibration weight(s) - either 1x100 or 2x50, and I'll even double check them on my 4-decimal scale for you. I think I have some extras around, and you really don't need several dozen of them, just a few.
    Guidelines for OD ||| OD Standards ||| OD Directory Read Me First! ||| NPD Rules
    Please read the links above or PM me if I lock your post. Stay Safe. R.I.P. F28
    Reply With Quote
     

  13. Collapse Details
     
    #38
    I figured this'd probably be the place to post this. Playing around with ChemSpider, I've "discovered" a few potential RCs and was wondering whether there was a particular reason some of them wouldn't be good:
    • MDIPA - Comparing iso-amp to amp, it'd probably just last longer and be a bit weaker?
    • 4-MMAR (4-Methylmethaminorex) - Would probably be expensive to make because of the norephedrine ban.
    • βk-MDAT - ?
    • 4-IMC - 4-Iodomethcathinone - ?
    • 4-FC - 4-Fluorocathinone - ?
    Reply With Quote
     

  14. Collapse Details
     
    #39
    Moderator
    Neuroscience and Pharmacology Discussion
    sekio's Avatar
    Join Date
    Sep 2009
    Location
    Atreides Palace
    Posts
    18,590
    What is iso-amp? beta-methylphenethylamine?

    4-MMAR has been made before I think, but not on a large clandestine scale. I think 4,4-DMMAR has been sold though!

    BK-MDAT I thought was known and crappy.

    4-IMC, like 4-Bromomethcathinone, is expected to probably be a triple monoamine releaser/reuptake inhibitor, however its amphetamine relative 4-bromoamphetamine is a selective serotonergic neurotoxin. All the 4-substituted haloamphetamines are except 4-fluoro. So people tend to stay away from the 4-halocathinones (except 4-FMC).

    "Plain" cathinones are not as stable nor as potent as methcathinones, so they aren't typically sold.
    Guidelines for OD ||| OD Standards ||| OD Directory Read Me First! ||| NPD Rules
    Please read the links above or PM me if I lock your post. Stay Safe. R.I.P. F28
    Reply With Quote
     

  15. Collapse Details
     
    #40
    Bluelight Crew Solipsis's Avatar
    Join Date
    Mar 2007
    Location
    NL
    Posts
    15,177
    MDIPA makes it sound like methylenedioxy-N-isopropylamphetamine, MDIP which yes is weak: https://www.erowid.org/library/books...ihkal108.shtml

    It's certainly possible that 4-halocathinones can't really be compared to haloamps but I still wouldn't touch them with a 20 ft pole, aside from 4-FMC indeed, I like fleph a lot but haven't indulged in like 8 years or something.

    ^^ pm'ed sekio for that mighty nice offer

    Question: do metabolites of known and FDA approved drugs have to pass every and all trials again, even if you'd be prepared to prescribe them at a dose no higher than the amount of metabolite produced by safe dosages of the parent? I guess they do since you can never know how the parent attenuates certain toxicity or heavily competes for a sort of further metabolism that would produce greater quantities of a toxic further metabolite?
    Last edited by Solipsis; 20-01-2017 at 22:10.
    Reply With Quote
     

  16. Collapse Details
     
    #41
    Bluelight Crew Solipsis's Avatar
    Join Date
    Mar 2007
    Location
    NL
    Posts
    15,177
    I didn't think this would warrant its own thread so:
    - could any interesting or unusual interactions take place from theanine with NMDA antagonists, even if this would require pretty heavy dosages? Any comment on how theanine could affect the interaction observed between nootropics and dissociatives?
    Reply With Quote
     

  17. Collapse Details
     
    #42
    I had a dog that used to have seizures if she had msg
    Reply With Quote
     

  18. Collapse Details
     
    #43
    Bluelight Crew Solipsis's Avatar
    Join Date
    Mar 2007
    Location
    NL
    Posts
    15,177
    MSG is more toxic to dogs, they can get brain damage or die.
    Reply With Quote
     

  19. Collapse Details
     
    #44
    Bluelighter MDPV_Psychosis's Avatar
    Join Date
    Mar 2012
    Location
    Norcal
    Posts
    738
    Quote Originally Posted by Solipsis View Post
    MSG is more toxic to dogs, they can get brain damage or die.
    Oh shit, I didn't know that. Is it bad enough that they shouldn't have any msg at all? Or just not in large amounts? My dog eats our leftovers which can sometimes contain msg.
    Reply With Quote
     

  20. Collapse Details
     
    #45
    Bluelight Crew Solipsis's Avatar
    Join Date
    Mar 2007
    Location
    NL
    Posts
    15,177
    As the toxic quantities are just lower and it can be hard to gauge MSG content in something like chinese takeout, I would really avoid letting your dog eat that... personally.

    Question is: when is the amount of MSG added really tiny? If it's that tiny it may either be pointless for your flavor of the food or it's unintentionally an ingredient in an ingredient you cooked with yourself: a trace I guess. (possible example perhaps is yeast extract in some chicken stock that you added to your risotto... It's probably okay in situations like that although the parmesan may be way too salty for your pets too, but it's probably better to avoid things like Chinese with a bunch of ve tsin thrown in.

    I won't tell you what to do with your pets but I myself wouldn't use dogs or cats as a "dumpster" (not meant agressively or offensively) with maybe the odd exception when you know what you're giving. I guess leftovers are not during your dnner, but I also have experience with dogs and cats begging at the dinner table, but IMO / IME you need boundaries as not to reinforce that behavior and if you love your pet I think you should not give them your food on a regular basis (i.e. just anything), rather than thinking you are doing them a favor as a treat... The dumpster thing (to avoid wasting food by throwing it away) seems better spent on pigs or goats although there are still limits.
    Not that I know much about parenting, but sometimes you gotta say no (just get quality dog food that is nutritionally healthy for dogs if you want to be good to em - at the risk of them getting dependent on it and getting high standards / spoiled).

    If you live in the countryside a couple of pigs is pretty cool as a livestock type pet... we used to have 2 pigs at the biological fruit / veg garden I worked at in the past, they lead quite a nice life I believe, and got some veg waste etc... I applied for part of their bio meat when they were getting old and it was time to put an end to their lives. It's a bit weird that I used to know the animals, but it helps that they weren't treated like an object nor suffered.
    Last edited by Solipsis; 08-04-2017 at 15:00.
    Reply With Quote
     

  21. Collapse Details
     
    #46
    Bluelighter MDPV_Psychosis's Avatar
    Join Date
    Mar 2012
    Location
    Norcal
    Posts
    738
    I said leftovers but I meant that it begs around the dinner table until somebody gives in.

    This has prompted me to do some research. I was already aware of some things dogs should not eat apparently I was not fully up-to-date.

    Dog already gets quality dog food. I just need to convince all those at the dinner table to not give in so much.

    Thank you for the response.
    Reply With Quote
     

  22. Collapse Details
     
    #47
    Bluelight Crew Solipsis's Avatar
    Join Date
    Mar 2007
    Location
    NL
    Posts
    15,177
    Was 13-HO-LSD ever further tested pharmacologically? I thought Nichols was planning on doing that, but I don't recall hearing about confirmation of it's supposedly highly potent dopaminergic effects.
    Reply With Quote
     

  23. Collapse Details
     
    #48
    Bluelighter Nagelfar's Avatar
    Join Date
    Nov 2007
    Location
    Vancouver, Washington USA
    Posts
    1,951
    An endogenous ligand of the brain sigma/PCP receptor antagonizes NMDA-induced neurotransmitter release. Brain Res. 1987 Jul 21;416(1):84-9. PMID: 2887250

    ^What's the deal with the above? An endogenous ligand found for the PCP receptor (an *orphan* receptor), but this publishing is from '87!
    Reply With Quote
     

  24. Collapse Details
     
    #49
    Moderator
    Neuroscience and Pharmacology Discussion
    sekio's Avatar
    Join Date
    Sep 2009
    Location
    Atreides Palace
    Posts
    18,590
    I thought it had been established that "PCP receptors" were sigma receptors or NMDArs, not some exotic new unclassified GPCR.
    Guidelines for OD ||| OD Standards ||| OD Directory Read Me First! ||| NPD Rules
    Please read the links above or PM me if I lock your post. Stay Safe. R.I.P. F28
    Reply With Quote
     

  25. Collapse Details
     
    #50
    Bluelight Crew Solipsis's Avatar
    Join Date
    Mar 2007
    Location
    NL
    Posts
    15,177
    https://archives.drugabuse.gov/pdf/monographs/133.pdf go nuts?

    It seems that in part of the brain PCP receptors are coupled to NMDA receptors / part of the complex while in other parts of the brain they are not coupled to a functional NMDAr complex (unsure what it might be coupled to there) and these types behave differently. PCP receptors and sigma receptors apparently differ in their ability to complex with the NMDAr and they have a different distribution in the brain, plus particular differences in affinity of certain exogenous ligands.
    They haven't specified these different PCP receptors with certain names or designation?

    And there are endogenous PCP and sigma receptor ligands with various types of activity which are all at least partially peptide-like in nature.

    Quick 'odd' question: what is the best explanation for me getting terribly tight and painful feelings on the inside of my thighs in particular from lysergamides and does anyone else get that? Feels like a super stiff tendon just running down the inside of my legs... I do know there is a quite slim muscle there, but can't figure out why that area would be the main issue with after effects...
    Last edited by Solipsis; 19-05-2017 at 21:32.
    Reply With Quote
     

Page 2 of 3 FirstFirst 123 LastLast

Posting Permissions

  • You may not post new threads
  • You may not post replies
  • You may not post attachments
  • You may not edit your posts
  •