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Thread: Study: FLP-7 Neuropeptide Triggers Fatburning in Gut

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    Study: FLP-7 Neuropeptide Triggers Fatburning in Gut 
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    As anyone who's dabbled with MDMA and other serotonin-releasing compounds may have noticed, fatloss seems to be a pretty common side-effect. Obviously that's partly related to the poor nutrition, lack of appetite and high energy output that tends to accompany use.

    However a new paper published in Nature on Friday is helping to uncover another of the probable links between serotonin release and fat metabolism: the neuropeptide FLP-7.

    As the researchers state: "a neural circuit in the brain produces serotonin in response to sensory cues, such as food availability. This signals another set of neurons to begin producing FLP-7. FLP-7 then activates a receptor in intestinal cells, and the intestines begin turning fat into energy."

    Now I'm not suggesting bodybuilders should go out and pop an E before training (!) since (as you probably know) serotonin is intricately involved in numerous other critical physiological functions. However this finding could have interesting implications for those suffering from depression and/or poor mood who often seem to put on weight. And unlike serotonin itself, FLP-7 appears to have fewer extraneous effects outside fatloss, so may be another potential miracle cutting agent (alongside asprosin blockers) to watch out for in the future.

    Anyway for a magazine-style run through of the paper, read >>this<< article from ScienceDaily. For the abstract and link to the full (free) paper, read below:


    A tachykinin-like neuroendocrine signalling axis couples central serotonin action and nutrient sensing with peripheral lipid metabolism (2017)

    Lavinia Palamiuc, Tallie Noble, Emily Witham, Harkaranveer Ratanpal, Megan Vaughan & Supriya Srinivasan

    Serotonin, a central neuromodulator with ancient ties to feeding and metabolism, is a major driver of body fat loss. However, mechanisms by which central serotonin action leads to fat loss remain unknown. Here, we report that the FLP-7 neuropeptide and its cognate receptor, NPR-22, function as the ligand-receptor pair that defines the neuroendocrine axis of serotonergic body fat loss in Caenorhabditis elegans. FLP-7 is secreted as a neuroendocrine peptide in proportion to fluctuations in neural serotonin circuit functions, and its release is regulated from secretory neurons via the nutrient sensor AMPK. FLP-7 acts via the NPR-22/Tachykinin2 receptor in the intestine and drives fat loss via the adipocyte triglyceride lipase ATGL-1. Importantly, this ligand-receptor pair does not alter other serotonin-dependent behaviours including food intake. For global modulators such as serotonin, the use of distinct neuroendocrine peptides for each output may be one means to achieve phenotypic selectivity.

    http://www.nature.com/articles/ncomms14237
    Last edited by CFC; 29-01-2017 at 22:05.
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    Bluelighter Intense's Avatar
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    So does this also mean that if we stand in front of a bakery shop and see all the food availability that our Serotonin will spike thus causing us to shed fat?




    Would be nice if so lol.
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    Looks like the research was done on roundworms, would be interesting to see if same results occurred in humans..
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    For the sake of science I'm prepared to volunteer lol
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    I suppose I would too if it's for research. My lady would also volunteer..
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    So the serotonin fluctuation is sufficient for FLP-7 production, but is it necessary? Or will the idea be to introduce this to the fitness market without messing with one's serotonin?
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    The idea would be to introduce it without messing with 5-HT. We'd need studies on humans to determine both efficacy and side-effect profile. Though frankly - depending on how easy it is to synthesise - I'd anticipate it coming to the market long before then, as you might imagine.
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