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Thread: Can paracetamol be separated from diphenhydramine HCL?

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    Can paracetamol be separated from diphenhydramine HCL? 
    #1
    I would like the experience of diphenhydramine despite the many criticisms of it as inducing terrible hallucinations. I heard that it can be good at lower doses.

    The only problem is, I'm in Ireland and unlike the US or UK, the diphenhydramine OTC products contain paracetamol which definitely isn't too good for the liver or stomach seeing as each tablet contains 25mg of the deliriant and I would need to take several to get any effect.

    I believe I read on another forum that the process is too complex, time consuming and costly. Apparently, it's cheaper to fly to the US or UK than try and separate the paracetamol from the deliriant.
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    #2
    Bluelighter SheWasLvL18's Avatar
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    Based on the information at https://pubchem.ncbi.nlm.nih.gov I believe a Cold-Water Extraction might be sufficient. How much paracetamol is in each tablet?
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    #3
    Quote Originally Posted by SheWasLvL18 View Post
    Based on the information at https://pubchem.ncbi.nlm.nih.gov I believe a Cold-Water Extraction might be sufficient. How much paracetamol is in each tablet?
    500mg.
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    #4
    Bluelighter SheWasLvL18's Avatar
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    Quote Originally Posted by cowardescent View Post
    500mg.
    According to the site acetaminophen's solubility in water is 1 to 5 mg/ml at 72 degrees Fahrenheit.
    So I would perform a cold-water extraction with 500 ml of water to be safe. (1 water bottle)
    It's been some time since I have done a CWE personally, so if I am wrong someone please correct me.
    Steps:
    1. heat 500 mL of water to lukewarm heat (above 72 fahrenheit)
    2. Crush tablets and pour the powder into the lukewarm water
    3. Place in the freezer for 30 min and once a white powder (paracetamol) has formed in the solution take it out.
    4. Strain through cheesecloth or coffee filter and throw away the filter and white powder
    5. Drink up and enjoy!

    EDIT: I believe this should work because DPH seems to be very soluble in water, whereas paracetamol requires the heated water to dissolve. Therefore, once the solution has cooled the paracetamol should have "crashed out" so to speak.
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    #5
    Quote Originally Posted by SheWasLvL18 View Post
    According to the site acetaminophen's solubility in water is 1 to 5 mg/ml at 72 degrees Fahrenheit.
    So I would perform a cold-water extraction with 500 ml of water to be safe. (1 water bottle)
    It's been some time since I have done a CWE personally, so if I am wrong someone please correct me.
    Steps:
    1. heat 500 mL of water to lukewarm heat (above 72 fahrenheit)
    2. Crush tablets and pour the powder into the lukewarm water
    3. Place in the freezer for 30 min and once a white powder (paracetamol) has formed in the solution take it out.
    4. Strain through cheesecloth or coffee filter and throw away the filter and white powder
    5. Drink up and enjoy!

    EDIT: I believe this should work because DPH seems to be very soluble in water, whereas paracetamol requires the heated water to dissolve. Therefore, once the solution has cooled the paracetamol should have "crashed out" so to speak.
    Thank You .

    Hopefully the trip doesn't go south as many people on erowid and here say.
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    #6
    Bluelighter SheWasLvL18's Avatar
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    No problem! I've only had one experience with DPH at the end of a DXM trip and it was fun, but definitely crazy. It felt like whenever I closed my eyes I was in a dream. Like I would close my eyes and see lines of soldiers and then I would open them and only 30 seconds would have passed, rather than hours that I had felt.
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