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Thread: (825mg Pregabalin, 225mg Venlafaxine) - average- This is an easy and incredible combo

  1. #1
    Bluelighter delphinen's Avatar
    Join Date
    Mar 2007

    Lightbulb (825mg Pregabalin, 225mg Venlafaxine) - average- This is an easy and incredible combo

    I just want to write down that I have been enjoying high amounts of Pregabalin (Lyrica) 650-1000mg with a medium amount of Venlafaxine (Effexor), enough to inhibit the reuptake of Dopamine in theory, and it is a incredible combo.
    When I mix Pregabalin with Tramadol which has a similar structure to Venlafaxine I don't get the "power" and "happiness" I feel right now. I could swear there is some little opioid feeling, specially in my legs and arms, so I searched in Wikipedia...

    Quote Originally Posted by Wikipedia
    ..Venlafaxine indirectly affects opioid receptors (mu-, kappa1- kappa3- and delta-opioid receptor subtypes) as well as the alpha2-adrenergic receptor, and was shown to increase pain threshold in mice. When mice were tested with a hotplate analgesia meter (to measure pain), both venlafaxine and mirtazapine induced a dose-dependent, naloxone-reversible antinociceptive effect following intraperitoneal injection. These findings suggest venlafaxine's seemingly superior efficacy in severe depression as opioids become increasingly used as a measure of last resort for refractory cases.
    so it feels a little similar to very low dose of Tramadol or Codeine, with the stimulating effect of Venlafaxine (it can be mistaken as Cocaine in some tests!), and the blessing in general of a really high dose of Pregabalin is awesome.

    +Both drugs are easy to get, I'm Bipolar II, that's why I get them
    +None of the drugs are dangerous if you have at least 10mg Diazepam in case you flood Serotonin in your brain because of the Venlafaxine
    +Last 24 hours
    -Increase appetite
    -have to wait at least 4-5 days to feel it again

    Tagged by Xorkoth
    Last edited by Shadowmeister; 09-11-2018 at 21:10.

  2. #2
    Bluelighter delphinen's Avatar
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    Mar 2007
    I added 400mg of Codeine with Coca-Cola. Will edit and report later.

    +2 hours later

    The "high" of Venlafaxine and Pregabaline were changed for a feeling of well being, and pleasure on the limbs thanks to the Codeine. I believe I am an extensive metabolizer of CYP2D6 (have multiple copies of the enzyme) , because both the Venlafaxine and Codeine works with it, and even taking the Venlafaxine the Codeine worked .... amazing.

    I feel calm. Not happy, not angry, I feel nothing nothing but calm, a little more social than usual, and feel a lot of pleasure on my body. I am a little addict to Codeine and never works this well, who knows why it's being metabolizing so well today.

    So... if I take something more or something interesting happens I will post it.

    Imagine a world were opioids and opiates are legal
    Last edited by delphinen; 09-11-2018 at 22:22.

  3. #3
    Senior Moderator
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    Shadowmeister's Avatar
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    Feb 2006
    Thanks for sharing. I love pregabalin, I have never heard of combining it with venlafaxine, but I have heard some real horror stories about venlafaxine, however.

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