Benzos Ketazolam? WTF is this?!

[RandomClean3]

I'm about to start taking ketazolam for non-recreational reasons (as much an addict trrying to quit methadone can) and what you guys are missing is that ketazolam is a daily pill, diazepam is recomended to be taken 3 times a day, so when you compare them you're comparing taking 1 pill of each and the effects it has for how long. If triazolam for example was compared to diazepam not considering this, it would be 1mg to 10mg of diazepam instead of 0,25mg. What I'm saying is 30mg of ketazolam are more equivalent 10mg of diazepam 3 times in one day. Druggies like us prefer fast-acting short lasting drugs but for the long time we know how bad they are for you. I'm taking this so I drop methadone and move the fuck on with my life, I was already addicted to benzos for over a decade. And when I'm done with this, I won't even have to switch to diazepam since this is smoother.

One more thing, I am biochemist (It's just my job, for some reason people think I'm lying as if I said I was an astronaut in these types of conversations). This molecule wants to die in the human body. Oxazolobenzodiazepines which are analogues to ketazolam are already reactive for near 100% conversion. But ketazolam 1) Is has a 6 membered ring, a lot more unstable 2) It's not an amine but a lactone, which tend to have half life of minutes in the body, specially with the steric involvement of the diazepine ring 3) The oxygen closest to the phenyl is conjugated to not only a double bond, a carbonyl and a carbonyl of a carboxylic acid (after the hydrolisis of the lactone) making it an incredibly good leaving group that leaves, remaking the double bond. This is a very, very well engineered drug, there's a reason I chose it over diazepam (that I was already taking) Also, basically everything I just said is org chemistry more than anything so I think plenty of people can see just how reactive this is and how much it wants to be diazepam, but still over a period of time that makes it a 24 hour pill. God that was long, I'm tired of myself already.

 

[Jabberwocky]

I'm about to start taking ketazolam for non-recreational reasons (as much an addict trrying to quit methadone can) and what you guys are missing is that ketazolam is a daily pill, diazepam is recomended to be taken 3 times a day, so when you compare them you're comparing taking 1 pill of each and the effects it has for how long. If triazolam for example was compared to diazepam not considering this, it would be 1mg to 10mg of diazepam instead of 0,25mg. What I'm saying is 30mg of ketazolam are more equivalent 10mg of diazepam 3 times in one day. Druggies like us prefer fast-acting short lasting drugs but for the long time we know how bad they are for you. I'm taking this so I drop methadone and move the fuck on with my life, I was already addicted to benzos for over a decade. And when I'm done with this, I won't even have to switch to diazepam since this is smoother.

One more thing, I am biochemist (It's just my job, for some reason people think I'm lying as if I said I was an astronaut in these types of conversations). This molecule wants to die in the human body. Oxazolobenzodiazepines which are analogues to ketazolam are already reactive for near 100% conversion. But ketazolam 1) Is has a 6 membered ring, a lot more unstable 2) It's not an amine but a lactone, which tend to have half life of minutes in the body, specially with the steric involvement of the diazepine ring 3) The oxygen closest to the phenyl is conjugated to not only a double bond, a carbonyl and a carbonyl of a carboxylic acid (after the hydrolisis of the lactone) making it an incredibly good leaving group that leaves, remaking the double bond. This is a very, very well engineered drug, there's a reason I chose it over diazepam (that I was already taking) Also, basically everything I just said is org chemistry more than anything so I think plenty of people can see just how reactive this is and how much it wants to be diazepam, but still over a period of time that makes it a 24 hour pill. God that was long, I'm tired of myself already.

You can take diazepam once a day. The half-life of diazepam and desmethyldiazepam (it's primary metabolite) is on the order of DAYS. Oxazepam and Temazepam are extremely minor metabolites. After taking diazepam for a week, it's useless to take it three times a day. The entire dose can be taken in the morning. With no real disruption of plasma concentrations of diazepam or its metabolites.

Wikipedia is wrong about demoxepam. It is a metabolite of chlordiazepoxide (Librium) NOT diazepam, in fact, it's used to test whether chlordiazepoxide has been administered.

Use of direct-probe mass spectrometry as a toxicology confirmation method for demoxepam in urine following high-performance liquid chromatography - PubMed

The identification of the metabolite demoxepam in human urine establishes that chlordiazepoxide, a common benzodiazepine, has been administered. Like N-oxide metabolites of other drugs, demoxepam cannot be detected by gas chromatography-mass spectrometry (GC-MS), due to thermal decomposition...

pubmed.ncbi.nlm.nih.gov

I actually prefer chlordiazepoxide to diazepam.

 

[RandomClean3]

You can take diazepam once a day. The half-life of diazepam and desmethyldiazepam (it's primary metabolite) is on the order of DAYS. Oxazepam and Temazepam are extremely minor metabolites. After taking diazepam for a week, it's useless to take it three times a day. The entire dose can be taken in the morning. With no real disruption of plasma concentrations of diazepam or its metabolites.

Wikipedia is wrong about demoxepam. It is a metabolite of chlordiazepoxide (Librium) NOT diazepam, in fact, it's used to test whether chlordiazepoxide has been administered.

Use of direct-probe mass spectrometry as a toxicology confirmation method for demoxepam in urine following high-performance liquid chromatography - PubMed

The identification of the metabolite demoxepam in human urine establishes that chlordiazepoxide, a common benzodiazepine, has been administered. Like N-oxide metabolites of other drugs, demoxepam cannot be detected by gas chromatography-mass spectrometry (GC-MS), due to thermal decomposition...

pubmed.ncbi.nlm.nih.gov

I actually prefer chlordiazepoxide to diazepam.

If you are an addict you prefer drugs than don't hit you fast. Diazepam is very fast, it's way more likely to completely destroy my like. Also, you're confusing duration of action and half life. All of these drug are lipophilic and protein bound. Diazepam is know to be very protein bound, 98-99%, and most of it distribute into fatty tissue, so it doesn't last as long as the half life, in my experience it's 6-8 hours. This is shared by a lot of people. If it lasts mean you think phenobarbital fucks you up for a week? You're way oversimplifying how this works. And we haven't mentioned volume of distribution that's probably the most important aspect asides from half-life. The diazepam kicks infor a few hours, then the protein-bound and fat tissue dissolved diazepam is slowly released and metabolized, that's the half life. The amount of diazepam that can bind to GABA receptors goes does a lot more quickly than the half life. Metadone has a half-life of let's say 24 hours (It's very complicated, but let's go with that as average) A person in the hospital arrives with severe pain, they give them 5 mg of methadone, the pain subsides. You think that patient won't need more pain relief for 24 hours? Methadone duraction of effect is 4-8 hours. All of this to say, half-life =/= duration of action..

 

[Señor Moreno]

I have been prescribed Ketazolam (brand name Sedotime, years ago) 15 and 30mgs. Many times. It 100% sucks.
Very weak as anxyolitic, no value as a sleeping aid, not enough muscle relaxation if you don't overdo it.
The benzo effect of ketazolam is a "meh" and sad kind of dullness. And not even that as an actual and evident feeling, but as a lazy promise, if that makes sense.
It is similar to oxazepam but even worse, and If I were to compare it to other benzos, I would say ketazolam is as boring as lorazepam but as weak as Librium.
It has nothing to do with actual diazepam.

And last but not least, it has the biggest depression- leading potential that I have ever seen in a benzo.

 

[RandomClean3]

I have been prescribed Ketazolam (brand name Sedotime, years ago) 15 and 30mgs. Many times. It 100% sucks.
Very weak as anxyolitic, no value as a sleeping aid, not enough muscle relaxation if you don't overdo it.
The benzo effect of ketazolam is a "meh" and sad kind of dullness. And not even that as an actual and evident feeling, but as a lazy promise, if that makes sense.
It is similar to oxazepam but even worse, and If I were to compare it to other benzos, I would say ketazolam is as boring as lorazepam but as weak as Librium.
It has nothing to do with actual diazepam.

And last but not least, it has the biggest depression- leading potential that I have ever seen in a benzo.

Well, that's the point, they want to keep junkies away and what you consider a high most people consider a bad side effect, it was literally designed to be milder (less high). In my case, as an aid to come off methadone it's been really useful. Doesn't give me as much cravings as diazepam or flunitrazepam or clonazepam, I've already had to leave benzos after a decade long addiction, I already seizured, I hallucinated, I nearly killed myself. I'm fucking done, but I need something to keep sane as I drop the methadone. Also, this is a prodrug, it's gonna be very different for different people, some will feel it as pretty much diazepam, some won't feel it at all.

 

[RandomClean3]

Never did, even when I did heroin and I wanted to sleep I would take mirtazapine, it was my go to sleep/anxiety aid. Small doses sleep, bigger anxiety. Such a good benzo, at least my stash was

Did you call mirtazapine a benzo? I'm confused.

 

[Señor Moreno]

Well, that's the point, they want to keep junkies away and what you consider a high most people consider a bad side effect, it was literally designed to be milder (less high). In my case, as an aid to come off methadone it's been really useful. Doesn't give me as much cravings as diazepam or flunitrazepam or clonazepam, I've already had to leave benzos after a decade long addiction, I already seizured, I hallucinated, I nearly killed myself. I'm fucking done, but I need something to keep sane as I drop the methadone. Also, this is a prodrug, it's gonna be very different for different people, some will feel it as pretty much diazepam, some won't feel it at all.

Yes, I totally get your point about a non abusable benzo being safer for people prone to abuse them, but, at the same time, this laking of abusability also means that that specific benzo is not suited for situations were you need a hard benzo effect, as a good dose of alprazolam for a panic attack, certain level of muscle -esqueletic ( sp?) relaxation. Very weak benzo for most acute benzo purpouses, maybe useful for chronic matters.
Anyway, that's my only my experience and it's fantastic that ketazolam works for you.

 

[RandomClean3]

Yes, I totally get your point about a non abusable benzo being safer for people prone to abuse them, but, at the same time, this laking of abusability also means that that specific benzo is not suited for situations were you need a hard benzo effect, as a good dose of alprazolam for a panic attack, certain level of muscle -esqueletic ( sp?) relaxation. Very weak benzo for most acute benzo purpouses, maybe useful for chronic matters.
Anyway, that's my only my experience and it's fantastic that ketazolam works for you.

I wouldn't use it for a panic attack, it takes a couple of hours to kick in and by then you suffered the panic attack (Yes, this literally happened to me lol) I asked to keep a few valiums in case I need something quick. But I will say, it's very slow, but I really wouldn't call it weak. It can maintain high concentrations of diazepam and nordazepam for a very long time, you take for a while and once you stop you'll have high concentrations of benzos for 10 days. I'd think it would make a great anti-epileptic but diazepam is not that good for that. The way I see it is akin to using a fent patch and having roxies as rescue.

One more thing, it's not very fun to abuse at normal to high ranges, But if you're a maniac and decide to take 10 at once, you just commited yourself to be very fucked up for a couple of days. If someone is in that stage of their addiction, I imagine it can be a scary drug.