Search results for query: SSRI and cocaine

Unless you’re doing a 20 year bid…..Bupropion is a mild stimulant with negligible dopaminergic properties, and has very little abuse potential….as it does NOT induce euphoric effects. Methylphenidate (Ritalin) & Cocaine are nearly identical as “Inverse Agonists” at DAT/SERT/NET and increasing /...

F@ck….I’ve been using Cocaine daily for many months…..3-4 maybe….replacing my daily Methylphenidate (Ritalin) but usually after my Methadone 80mg, Lyrica 300mg…in 45min breakfast, then a mixed drink and a few nice lines before enjoying drink with a cigarette $200 for 2 grams….lasting 2-3 days...

That combination of medication (SSRI + antipsychotic + lithium) is going to significantly blunt the effects of cocaine as well as certain other drugs. It could also potentially cause some dangerous side effects.

Just out of interest, could you compare methylphenidate and bupropion effects when used orally at typical doses?

Bupropion (Wellbutrin) I’ve used off and on for years….smoking cessation, an antidepressant, off label ADHD, and others to augment effects of SSRI, increase sexual desire in women who are uninterested in sex, increases sexual desire in both sexes, often used to reverse effects from SSRI meds I...

Can you explain how comes Cocaine nullifies a MDMA high. Which afaik is a triple releaser and inhibitor. Same for an SSRI, on a SSRI forget MDMA while Coke and MPH will work.

I think it is because cocaine attaches to the transporters directly and inverses them while amphetamines work indirectly (e.g. over trace amino receptors) to release transmitters. When the transporters are blocked, indirect activity gets nullified. Same for plain transporter antagonists like...

I have no idea if this is true just something I thought about. Do you guys think that could be? I have s theorynthat they only start working after so long is because they become addicted to it in those first few weeks so it's like getting a drug you're addicted to, and once you get it your...

Zoloft or any SSRI can indeed work. Ive tried them all and stopped each SSRI within one week after starting. I then got on Klonopin, and took 1-2mg daily for 4 years. I can tell you Klonopin or benzos arent the answer… I took them just to make blow comedowns easily bearable.. If you actually...

This my worst advice in ages, harm reduction wise. No, do it the other way around. If you are keen on the combo. Cocaine is among other's, a SSRI. These are, Fluoxetine Setraline and Paroxetine (Fluvoxamine is toxic imo). But they are al known known to completely blok MDMA. And also used in...

Yeah, methylphenidate has been studied for use in cocaine addicts, it's pharmacologically the closest thing to cocaine we have around, both are inverse agonists at monoamine transporters, just that cocaine binds to the SERT addictionally which MPH doesn't do. So maybe could a SSRI antidepressant...

it’s 13 years and in future that’s fine also we don’t say UTFS any-more Nice try pfizer xD

To me first month of invega felt like I just had major head trauma and I was going through cocaine and opioid withdrawal I had excruciating back pain too it eased up on month 2 then even more on month 3 then month 4 I had felt the anti psychotic withdrawal but it didn’t feel like what I said...

Wow, anhedonia is quite a severe symptom. More than just hormonal going on with all of these symptoms. r/depressionregimens, r/MAOIs, r/anhedonia Anyways, there are a few things that work for anhedonia. May wanna consult Dr. Ken Gillman or email him. Ketamine IVs, TCA, MAOI are the main meds...

100% agreed! There are some small studies showing efficacy of Buproprion (atypical SSRI, cathinone) or NAC. Don't know about Baclofen from my own experience. Pregabalin and F-Phenibut have helped myself with quitting stims. Be careful though not to trade the cocaine habit for another compound...

Yah man, I agree with the Paxil guy, an ssri might really help you, then you could slowly wean off of it. I know you said weed made things worse, but have you tried high CBC low THC weed? I’d recommend something with 5% or less THC, and 15% or more cbd. Maybe gabapentin, kava kava, black seed...

Cocaine is some sort of SSRI or SRI, so it actually cancels out MDMA. Couple that with the rapid hardbeat, sweating and totally different vibe. Not a nice combo. Cocaine after coming down of MDMA did work. Opposed to coming down of Amphetamine which makes MDMA shine. Couch lock shine with...

Age 16 - alcohol Age 17 - DXM, psilocybin, weed, SSRI (prescribed), ephedrine Age 19 - mephedrone Age 20 - dexamphetamine and methylphenidate (prescribed) Age 22 - methoxetamine, alpha-PVP, RTI-111 and other RCs Age 24 - buprenorphine, methadone Age 26 - cocaine, 4,4'-dimethylaminorex Age 29 -...

Just some of my personal experiences (inc. rx stuff that I didn't abuse/isn't recreational) SSRI - Sertraline (Zoloft) - found is VERY hard to cum for 2-3 weeks, like took forever and really had to fantasize a lot. After that it was harder than usual to come for some months, then gradually...

I never said a full blown-up roll. However, my physiology is such that I get major euphoria and horniness from SSRI's at normal doses. So yeah, 25-30 mg of sass or 5/6-APB DEFINITELY elevates me. It's above the threshold dose for regular people anyway. I've probably been rolling before you...