• Select Your Topic Then Scroll Down
    Alcohol Bupe Benzos
    Cocaine Heroin Opioids
    RCs Stimulants Misc
    Harm Reduction All Topics Gabapentinoids
    Tired of your habit? Struggling to cope?
    Want to regain control or get sober?
    Visit our Recovery Support Forums

Stimulants Amphetamines and depression

mcflurry

Bluelighter
Joined
Feb 14, 2019
Messages
41
Location
Berlin
WWII studies by allies revealed adding d-amphetamine to morphine sulphate significantly increased the analgesic properties.

Desoxyn, Desbutal, Dexamyl all amazing antidepressant

Methylphenidate (Ritalin) gave me amazing antidepressant effects when I started ….sadly, the euphoria fades. People always badmouth Ritalin, but it’s an inverse against nearly identical to Cocaine and is more potent than Cocaine. IV Ritalin (proper Pharma glass vials of pure powder) is a heavy hitter

Methylphenidate & Phenmetrazine are extremely euphoric antidepressants

Oxycodone was the best antidepressant I’ve ever taken…..I would formulate a special cocktail.

Dexedrine or Ritalin
Oxycodone IR
Diazepam

Oxycodone was the first drug to give me true euphoria. The second was one of the classic amphetamines…..Methylphenidate (Ritalin). Why do I feel so happy and outgoing? Why does it feel like my brain is cumming with dopaminergic euphoric bliss ?

im sorry but antidepressants are not supposed to give u euphoria or make u ‚ happy‘. all the substances u just listed numb our feelings - each in their own way. on top of that they create a physical and mental dependance. they cause more problems in the long term than they solve in the short term. antidepressants should be seen as ,brain fertilizers‘ that help with brain plasticity (creating new or enhancing existing neural pathways/synapses).

i dont mean to say ur comment is trash, but since this is a harm reduction forum, i totally do :)
 

DeathIndustrial88

Bluelighter
Joined
Jan 23, 2020
Messages
2,250
Location
The Land Of Nod
^^^^^^^
I'd say SSRIs/SNRIs/Antipsychotics just "numb" your feelings. They're also terrible on the body & come with their own host of dangerous risks.

I still experience my feelings, some times with even richer depth while on drugs. So that';s not universally true,

Also, the only reason it's thought that AD's shouldn't give anyone "euphoria" is due to stigma. Society has been conditioned to believe "feelings of well-being" are a bad thing.
Opioids were once even used for psychiatry and worked pretty well due to their ability to create "feelings of wellbeing".

As a person with incredible treatment resistant depression, I'd say "feelings of well-being" is a hell of a lot better for quality of life than being depressed everyday.
Also, if those drugs only "numbed" feelings, then "feelings of well-being" and "euphoria" wouldn't be "side effects", since those need to be "felt".
Not to mention that most clinical severe depression is not going to be "cured" by a round of antidepressants, so in reality, taking something to feel better becomes the only real option.

Of course the differences between stimulants & opioids & other drugs & personal body chemistry come into play as well. What works for other might not work for some. For example I have no idea how I know people who use meth everyday & enjoy it. Just like those same people can't see how I could use opioids everyday & enjoy it.
The most functional era of my life was when I used tramadol & heroin all the time. (minus when I was in withdrawal obviously). Can't say the same about my experiences on SSRIs/Antipsychotics.
 
Last edited:

Ismene2

Bluelighter
Joined
Oct 29, 2018
Messages
2,079
Speed is an antidepressant while you are on it - its when you come off it you want to die. And if you take it more often it can send you round the fucking loop. Worst and most devastating drug Ive ever taken, far more dangerous than heroin for causing severe mental problems. I will never touch the shit again as long as I have a hole in my arse.
 

plumbus-nine

Bluelighter
Joined
Apr 4, 2021
Messages
3,195
Location
CDMX
Also, the only reason it's thought that AD's shouldn't give anyone "euphoria" is due to stigma. Society has been conditioned to believe "feelings of well-being" are a bad thing.
Opioids were once even used for psychiatry and worked pretty well due to their ability to create "feelings of wellbeing".
Oh yeah, it's quite ironic that antidepressants mustn't feel good to be approved - many drugs with possibly great potential got shelved because the human volunteers likened the drugs. They rater let some organ toxicity slip through than the possibility of something making you feel great. I say they wouldn't approve morphine/oxy/etc if it was a novel drug these days. Rather deal with the pain.

Interesting that they approved ketamine for depression because that one does make you feel good but it's seriously restricted to infusions in specialized clinics. I think nobody besides a few selected chronic pain patients ever get ketamine for take home.

Venlafaxine has an almost unbearable withdrawal syndrome, as do many of the short acting SSRIs like paroxetine, citalopram etc. just by switching to fluoxetine with a 2-3 weeks long half life and using kratom I could stop it.
 

Vrachox

Bluelighter
Joined
Sep 20, 2022
Messages
53
^^^^^^^
I'd say SSRIs/SNRIs/Antipsychotics just "numb" your feelings. They're also terrible on the body & come with their own host of dangerous risks.

I still experience my feelings, some times with even richer depth while on drugs. So that';s not universally true,

Also, the only reason it's thought that AD's shouldn't give anyone "euphoria" is due to stigma. Society has been conditioned to believe "feelings of well-being" are a bad thing.
Opioids were once even used for psychiatry and worked pretty well due to their ability to create "feelings of wellbeing".

As a person with incredible treatment resistant depression, I'd say "feelings of well-being" is a hell of a lot better for quality of life than being depressed everyday.
Also, if those drugs only "numbed" feelings, then "feelings of well-being" and "euphoria" wouldn't be "side effects", since those need to be "felt".
Not to mention that most clinical severe depression is not going to be "cured" by a round of antidepressants, so in reality, taking something to feel better becomes the only real option.

Of course the differences between stimulants & opioids & other drugs & personal body chemistry come into play as well. What works for other might not work for some. For example I have no idea how I know people who use meth everyday & enjoy it. Just like those same people can't see how I could use opioids everyday & enjoy it.
The most functional era of my life was when I used tramadol & heroin all the time. (minus when I was in withdrawal obviously). Can't say the same about my experiences on SSRIs/Antipsychotics.
Omg you hit the the core problem with this one,,my country is afraid of euphoria and good feelings substances like hell.
So i need to manage my adhd,depression and others problems on my own,,amph is only thing that makes me alive,,i am very sad its illegal due to stigma.
Tnx
 

Vrachox

Bluelighter
Joined
Sep 20, 2022
Messages
53
Oh yeah, it's quite ironic that antidepressants mustn't feel good to be approved - many drugs with possibly great potential got shelved because the human volunteers likened the drugs. They rater let some organ toxicity slip through than the possibility of something making you feel great. I say they wouldn't approve morphine/oxy/etc if it was a novel drug these days. Rather deal with the pain.

Interesting that they approved ketamine for depression because that one does make you feel good but it's seriously restricted to infusions in specialized clinics. I think nobody besides a few selected chronic pain patients ever get ketamine for take home.

Venlafaxine has an almost unbearable withdrawal syndrome, as do many of the short acting SSRIs like paroxetine, citalopram etc. just by switching to fluoxetine with a 2-3 weeks long half life and using kratom I could stop it.
You are right,,omg you are so right.
All things that helped me with depression are illegal in my country,,including stims:
Also i was on venalafaxine 300mg for 3 years,,coming down of that shit was horror and it did nothing for my depression.
Tnx sending you much love
 

Dextro .45

Bluelighter
Joined
Apr 15, 2017
Messages
361
Location
Canada
Not just analgesic, they also increase euphoric properties when taken together. Once I got a prescription for methadone and methylphenidate which was among the most euphoric drug experiences and certainly the most euphoric prescription. Didn't take it for too long though, so I can't tell about how bad tolerance grows over time. Also I don't remember why I stopped it, I don't think it was due to side effects.


Different groups of antidepressants. SSRI is selective serotonin reuptake inhibitor, like Prozac/fluoxetine. SNRI is serotonin norepinephrine reuptake inhibitor like venlafaxine. TCA tricyclic antidepressant. Tetracyclics are like mirtazapine.
Lol, yes I am also on Methadone 80mg and Methylphenidate 30mg, combined with a Jin cocktail it’s VERY euphoric

Speedball and Brompton Cocktail are amazingly euphoric due to the dopaminergic stimulant in combination with the Opioid narcotic. Methadone & Ritalin + Ethanol = Pure Pleasure :)
 

kongoman

Bluelighter
Joined
Sep 26, 2022
Messages
409
Hello brothers!
I have some questions. I'm being prescribed with venlafaxine a couple of months ago and It was no working for my depression so my doc have decided to put on it bupropion. Do you think It's a good combo?
Nowadays I discovered amphetamine paste and this helped me a lot. Do you think I can combine venlafaxine225mg-bupropion150mg-amphetamine paste-methadone50mg ? I have a terrible insomnia, do you think there's so much stims?
Thank you in advance.
I send you positive vibez and lots of ❤️❤️
 

Vrachox

Bluelighter
Joined
Sep 20, 2022
Messages
53
I tried all possible antidepressants including venlafaxine and bupropion they did nothing for me
 

mcflurry

Bluelighter
Joined
Feb 14, 2019
Messages
41
Location
Berlin
i think my comment was a bit misunderstood.

depression is not about being sad/in a bad mood/dysphoric. depression is when youre stuck in that bad mood and nothing can pull u out of it. its about affective modulation. ergo: making somebody feel good all the time is not the solution per se.

euphoria and being only happy regardless of whats happening around is not healthy. to me its just another twisted form of numbness. lets compare it to the necessity of bodily pain in our life - painkillers are supposed to take away exessive pain, but when u accidentally cut urself with a kitchen knife, youre still supposed to feel it.
same with antidepressants …

yes, the antidepressants we have today are not the only solution and are only proven to be effective in severe depression. they do have side effects. there is certainly a lot of room for improvement. i was just trying to outline the general concept of antidepressant medication.
 

Rainman1964

Bluelighter
Joined
Jun 18, 2016
Messages
130
Location
California
It isn't natural for the human being to not feel their emotions. The problem -- and why there is drug addiction and other behavior society partakes in today that is so unhealthy -- is that these companies came along, you know what companies I'm taking about, the pharmaceutacal companies. And with advancements and discoveries in science over the last 100 years, chemists have formulated pills for everything. Pills to feel up when you feel down, or down when we're too high, pills just to feel different...you name it. It became the norm to try and not feel how we were feeling -- to go out of our way and avoid any feeling we did not like. The result is that we avoid our problem, what we need to face to fix our problem and most of us avoid knowing ourselves and can go through an entire lifetime missing out on everything.

Life if to be live and to feel everything, no matter how unpleasant it may seem. That's the gravy....

V
 

kongoman

Bluelighter
Joined
Sep 26, 2022
Messages
409
well said, great post @Rainman1964
most
of Us have the problem and the solution!
I
will take IT in considerity and I will think about it, dude...Meds and drugs possibly ruined my hole life ! I'll write on a paper all your post to have it in a visibility place so I'll can see your words . I'm have to react as soon as possible cause I'm immersed in a medical mood that I CAN'T escape...
thanks
brother!
You write well mister !
Send you😚😚
 

Rainman1964

Bluelighter
Joined
Jun 18, 2016
Messages
130
Location
California
well said, great post @Rainman1964
most
of Us have the problem and the solution!
I
will take IT in considerity and I will think about it, dude...Meds and drugs possibly ruined my hole life ! I'll write on a paper all your post to have it in a visibility place so I'll can see your words . I'm have to react as soon as possible cause I'm immersed in a medical mood that I CAN'T escape...
thanks
brother!
You write well mister !
Send you😚😚
Be Well!!
 

Skipperslilbuddy

Greenlighter
Joined
Dec 19, 2012
Messages
10
^^^^^^^
I'd say SSRIs/SNRIs/Antipsychotics just "numb" your feelings. They're also terrible on the body & come with their own host of dangerous risks.

I still experience my feelings, some times with even richer depth while on drugs. So that';s not universally true,

Also, the only reason it's thought that AD's shouldn't give anyone "euphoria" is due to stigma. Society has been conditioned to believe "feelings of well-being" are a bad thing.
Opioids were once even used for psychiatry and worked pretty well due to their ability to create "feelings of wellbeing".

As a person with incredible treatment resistant depression, I'd say "feelings of well-being" is a hell of a lot better for quality of life than being depressed everyday.
Also, if those drugs only "numbed" feelings, then "feelings of well-being" and "euphoria" wouldn't be "side effects", since those need to be "felt".
Not to mention that most clinical severe depression is not going to be "cured" by a round of antidepressants, so in reality, taking something to feel better becomes the only real option.

Of course the differences between stimulants & opioids & other drugs & personal body chemistry come into play as well. What works for other might not work for some. For example I have no idea how I know people who use meth everyday & enjoy it. Just like those same people can't see how I could use opioids everyday & enjoy it.
The most functional era of my life was when I used tramadol & heroin all the time. (minus when I was in withdrawal obviously). Can't say the same about my experiences on SSRIs/Antipsychotics.
You sure are right about that. I've noticed people usually have a preference when it comes to abusing opioids or meth-amphetamines. They say opioids and heroine are addictive, but even if I had an unlimited supply I couldn't care less. It's like paying good money to take something that puts me to sleep. Forget that, give me access to meth, then you better have a lot of it. But as far as antidepressants go, anyone that does meth or opioids while on taking antidepressants is wasting their time and their doctors time. And any thoughts on how ineffective they are should be taken with a grain of salt. It's been proven that they work for some people. But I highly doubt they will work for people like me who smoke out of a glass pipe every day. In fact I don't see how they would given the fact that I artificially cause my brain to release intense feelings of pleasure every time I take a hit. For certain people that don't do drugs and their depression is caused by a chemical imbalance in the brain... they can work wonders. Any side effects a person has can then be weighed against how effective the drugs are to them.
It isn't natural for the human being to not feel their emotions. The problem -- and why there is drug addiction and other behavior society partakes in today that is so unhealthy -- is that these companies came along, you know what companies I'm taking about, the pharmaceutacal companies. And with advancements and discoveries in science over the last 100 years, chemists have formulated pills for everything. Pills to feel up when you feel down, or down when we're too high, pills just to feel different...you name it. It became the norm to try and not feel how we were feeling -- to go out of our way and avoid any feeling we did not like. The result is that we avoid our problem, what we need to face to fix our problem and most of us avoid knowing ourselves and can go through an entire lifetime missing out on everything.

Life if to be live and to feel everything, no matter how unpleasant it may seem. That's the gravy....

V
That's a lot of BS. Why think it's a pharmaceutical company's fault when millions of people go to the doctor to get treated for depression. People are asking for these prescriptions, and then they are prescribed. Anyone taking antidepressants should know that they aren't formulated or created to make you feel good. None of them are. The intention is to restore a person that's having extended periods of depression back to normal,(whatever that may be for them) by correcting the levels of Serotonin or norepinephrine in the brain. If a person's depression isn't caused by an imbalance of either of those, Then they probably won't be of much help. If I want to "feel good" right now, I sure as heck wouldn't expect any help from a pharmaceutical company. Your blame of those companies is misplaced. If nobody ever went to the doctor for depression, their wouldn't be an industry built around treating it.
 

Boredmomma1983

Greenlighter
Joined
Dec 14, 2019
Messages
3
Please stay away From amphetamines , if you play with fire you will eventually get burned. Almost ruined my life.
 

DeathIndustrial88

Bluelighter
Joined
Jan 23, 2020
Messages
2,250
Location
The Land Of Nod
You sure are right about that. I've noticed people usually have a preference when it comes to abusing opioids or meth-amphetamines. They say opioids and heroine are addictive, but even if I had an unlimited supply I couldn't care less. It's like paying good money to take something that puts me to sleep. Forget that, give me access to meth, then you better have a lot of it. But as far as antidepressants go, anyone that does meth or opioids while on taking antidepressants is wasting their time and their doctors time. And any thoughts on how ineffective they are should be taken with a grain of salt. It's been proven that they work for some people. But I highly doubt they will work for people like me who smoke out of a glass pipe every day. In fact I don't see how they would given the fact that I artificially cause my brain to release intense feelings of pleasure every time I take a hit. For certain people that don't do drugs and their depression is caused by a chemical imbalance in the brain... they can work wonders. Any side effects a person has can then be weighed against how effective the drugs are to them.

That's a lot of BS. Why think it's a pharmaceutical company's fault when millions of people go to the doctor to get treated for depression. People are asking for these prescriptions, and then they are prescribed. Anyone taking antidepressants should know that they aren't formulated or created to make you feel good. None of them are. The intention is to restore a person that's having extended periods of depression back to normal,(whatever that may be for them) by correcting the levels of Serotonin or norepinephrine in the brain. If a person's depression isn't caused by an imbalance of either of those, Then they probably won't be of much help. If I want to "feel good" right now, I sure as heck wouldn't expect any help from a pharmaceutical company. Your blame of those companies is misplaced. If nobody ever went to the doctor for depression, their wouldn't be an industry built around treating it.
Agreed.
I've noticed that a lot of people who's DOC is methamphetamine, tend to just get sleepy from heroin & opioids & don't enjoy them. I'd say it's probably cause meth releases way more neurotransmitters than opioids. So you're not really gonna feel that unadulterated bliss of opioids if you already prefer meth. I've always found a stimulant + an opioid to be better than either alone. I always noticed that my heroin would feel a lot less euphoric if I used it after a meth binge.


But opioids feel more natural to me, where as if I do too much of a stimulant, I'll eventually start to get paranoia and anxiety. Along with sleep deprivation. Opioids however give me a few hours of clean feeling energy & motivation (not to mention a content feeling that nothing else in the world can give) & then eventually I can go to bed or take a nap. I can get all kinds of shit done while under the acute effects of an opioid but even meth doesn't give me any motivation to clean or get anything done, unless it's sex related. lol Just goes to show how differently we are all wired.

True point, that I can't understand how these doctors who know drug users are use to feeling complete euphoria are gonna get any better from a non euphoric drug like an AD.
 
Top