So a couple things about your deck. First of all you want to pick a single archetype and go with that rather than mixing multiple ones together. For example, you have discard mixing with zoo and random other stuff.
so you need to pick one theme and make everything in your deck work cohesive together so that you can maximize your efficiency.
Here is a good ongoing deck. Lots of synergies going on. Klaw and Namor. Iron man with Captain America and Spectrum. Sometimes if you get a lucky draw you can have Ant man, Cap, Klaw, Onslaught in one lane , namor in the other.
Colossus is very good in the early game for locations like negative zone and necrosha , his ability plus klaw can win those locations easily.
Another good play is playing onslaught on top of mister fantastic. That's 4 power in the left and right lanes.
Youll get the hang of it. Also: cosmo is good to protect your cards from enchantress. And spectrum is a great turn 6 surprise card to buff all your ongoing cards.
(paste this into your deck builder)
I'm at collection level 761. I recently acquired Gladiator, who is one of my favorite Marvel characters.