San Pedro + Caapi vine was an amazing combo, even if one of those is mostly just a potentiator. You have to be careful with that combo though because its possible to OD, where its very difficult to OD with the cactus by itself.
Mescaline and MDMA was divine bliss.
Peyote and opium was visionary.
Im a big fan of mescaline all around.
I have always wanted to try a speedball (or an opiate/coke solution, at least) , but i live in the country, and i wouldn't dare shoot the coke around here.
Instead I use meth and opiates in the same shot. I've always called it a super speedball, for lack of a better term. But I've heard shootin yay is actually better than shootin crank. I can believe the rush is, but I think I would still choose a meth injection over a yay injection, for duration of the high. The whole reason I hardly do coke in the first place.
Compared to the rush from coke, the meth rush is pathetically weak. You could always just add some meth in for a longer duration, but I'd just snort it along side, the meth would detract from the pure pleasure and synergy of the coke+opiate shot.