Fertile
Bluelighter
- Joined
- Mar 31, 2022
- Messages
- 1,628
I'm wondering if the N-phenylethyl homologue of morphine (x8 morphine in potency) has the same duration as morphine. After all, in MOST classes, when you swap from N-methyl to N-phenylethyl, the duration goes down. This is entirely dependent on if an appropriate enzyme will 'fit' with the biosteric bulk of the class.
For fentanyl CYP3A4 removes the N-phenylethyl.
Not many other classes have has specific metabolism of the N-phenylethyl homologues examined. I presume that is why BDPC has such a long duration. Their is no N-phenylethyl.
For fentanyl CYP3A4 removes the N-phenylethyl.
Not many other classes have has specific metabolism of the N-phenylethyl homologues examined. I presume that is why BDPC has such a long duration. Their is no N-phenylethyl.