I think I had been poisoned from an MDMA pill i took.

[lonelyDude]

I think a lot of the research into parkinsons is actually located around the DAT system or dopamine rather than serotonin.

again SARs and pharma are not my thing I like to build lego so to say

 

[DeathIndustrial88]

now your in my territory

I have overdosed a few times just to find were the limit was so I could tell others who used my products in the past.

shakes overheating and screamming pain in the head.

I used to have to do breathing excersises to get through it.

I never got the parkinsons symptoms after thankfully but it destroyed my seritonine production for years.

I used to be quite bipolar when I was younger but now I do not feel as much as I used to and I attribute this directly to brain damage.

my memory and focus still have some problems but with training and hard work as you guys know I can excel in nearly anything.

though I have met people who used massive doses all the time (I only did it for testing purposes) and they are truly what I call etarded.

there focus is so bad that a lot of the time they stare of into space.

MDMA does not work like normal psychedelics as it pushes seritonine out of the reuptake terminals which distorts them.

this makes for a leaky axon which I am not sure if it repairs or not.

from my experience I would say that it does to an extent or maybe due to neural plasticity it remaps but that is just me making shit up to

fit with my experience and not science.

I think a lot of the research into parkinsons is actually located around the DAT system or dopamine rather than seritonine.

again SARs and pharma are not my thing I like to build lego so to say

I've had these episodes on high doses of effexor, dxm, being overamped on meth & from long term tramadol use.

I'm not totally positive my myoclonic jerks are correlated. They started after I stupidly took DXM ontop of my effexor 8 years ago.
And instead of getting a trip, my toes began to curl up & I couldn't stand on my legs anymore as they had started convulsing. I took a klonopin & the convulsing stopped about 20-30 mins later. It took me awhile after that to realize what had happened to me. Not long after, I started having uncontrollable body jerking that has come & gone.

I've also had numerous times on antidepressants (yes, I will shamefully admit in the past when I was low, desperate & had nothing else to do, I would pop higher than normal doses of AD's just to 'change' my mood state), along with DXM (not usually at the same time, except for that time with effexor) and the like where I will get that sweating but cold, but feeling like your insides are burning up & losing your balance and vision/hearing fading in & out. For the longest time, I thought it was just 'side effect', but I grew to learn that it was most likely mild (and some times moderate) serotonin syndrome. So I started making sure to take a benzo if I start feeling that way, which has probably saved my life many times.

Had it once or twice on MDMA too, but I haven't done MDMA since I was a teenager.

Some doctors have said my jerks are probably related to brain damage from drug use, but they couldn't find any "brain damage" on my catscan.
I also was bit by a random tick not too long before the DXM/Effexor/Leg Convulsion episode. But I haven't been tested for lyme that I'm aware of.

I've been trying to figure out for years ever since what's causing these tics & jerks in me. Some times they are full body shocks like I've being electrocuted. Other times it's my legs that jerk or my torso. Usually when I'm at rest of laying down & relaxing, but some times they'll happen now when I'm upright & awake.

Some times my jerks will go away for 2 months or so & I'll think they're gone for good, only to pop back up again & some times more intensely. And I'm only 34. So I shutter to think how my limb control ability is gonna be when I'm like 65, if I even live that long.


As you said though, I've always thought movement was involved with dopamine. But I'm curious what if any role serotonin might also play into that.
I've read taking 5-htp depletes dopamine & that taking l-tyrosine can deplete serotonin, so they may be related or cross over some how. But I'm still slowly learning about stuff like this. lol
It can be really frustrating getting any answers!

 

[Purple pills]

In reply to your post death. I was given tramadol a long time ago when doing hi doses of it. Was maybe 20 at time. On Like 500mg plus a night. Apart from drink wasn't into drugs. When I was put onto morphine I had horrific night time jerks. Literally kick ppl out of bed lol.
Even taking lot of opiates apparent still did it. Mine took maybe a decade to stop.

 

[Desgueis]

@Purple pills Hey I'm still alive. Therefore maybe tramadol should help me? Take in consideration that is not pain what I feel. It's a pressure that seems to be press more & more my head as time passes by. But I'll definitely try Tramadol to see if I can improve. Thank you very much.

 

[lonelyDude]

think ssri or snri both block the reuptake terminals were MDMA is trying to un-naturally push the serotonin out of.

something has to give one is blocking the door the other is trying brake it down god knows what its really doing to you but for sure the axon and reuptake terminals will be screwed after.

never take an antidepressant and MDMA or MDA.

never seen this problem with acid or shrooms though I have heard it is possible to have problems with antidepressants and tryptamines but I have seen many poor bunnies in tears at rave parties because they

took XTC when on antidepressants.

but to be honest we all know this as you have said

back in my time on the stuff we used 5-htp to boost the serotonin then on the way down many (not me) used prozac to stop the come down.

now I look back on the idea with horror but its what the go was back in the 90's and 00's.

I would not be surprised if this lead to people being etarded much quicker than they would have otherwise.

this guy might be of some interest too you.

David E. Nichols - Wikipedia

en.wikipedia.org

this link has his email address.

David E. Nichols | MCMP

Faculty official web pages

www.mcmp.purdue.edu

if you were polite I would not be surprised if he would even talk to you about it and I think he is probably the best of us all when it come to this stuff.

 

[Desgueis]

never seen this problem with acid or shrooms though

Yeah that's why I'm so concerned. I looked a lot on the internet and I can't neither find anyone which is having this problem i'm having. Plus went to several doctors by now, and they don't have any clue either. The only thing they said is that I have a pre-psychotic stage, but I'm sure I'm not pre-psychotic, and everything feels so much physical, to the point that feels like if my head is going to explode or a vein on the brain is going to pop-up. I don't know what's really happening tbh. I'll keep you updated.

 

[Mr. Krinkle]

E-tards

 

[Desgueis]

to clarify: e-tard is retard?

 

[lonelyDude]

not quite its when XTC has done enough damage to the brain to leave the person hollow and without emotion.

often full swings of depression to go with it.

kind of like a broken android with absolutely no focus at all.

it happens more often than you would believe but mostly its due to the user not being responsible for them selves though not always we all have

limits and until you hit them you have not idea what they are.

some hit them like me and go ouch and stop others just keep on going and end up etarded.

remember shulgin took this drug religiously nearly every week just to write his journals on.

he was responsible and it did fuck all to him.

but then he was not trying to blow his past away in a night club either.

 

[lonelyDude]

another one to look into is the symptoms of saint anthony's fire (ergotism) just for interest really its not what you have but it is similar to serotonin syndrome in many ways
(well the mental effects not so much the black bits dropping off but the hallucinations and burning head and migraine are as I experienced it.)

St Anthony's Fire: The Tragic Illness That Plagued History - Grunge

Throughout history are instances of an illness that brought mass hallucinations. It was widely known as St. Anthony's Fire, and it had a very earthly origin.

www.grunge.com

were in the land of witchcraft here thats for sure

anyone for some ergot wine.

I really hope you can find the cause and then some relief with modern medicine.

please remember im just an ex cook though and not a doctor.

 

[Mr. Krinkle]

to clarify: e-tard is retard?

yea when your brain isn't working quite right after doing E

 

[Desgueis]

Hi all, specially @Endopharm which recommended me to do this,

I booked an MRI with angiography, which basically means that they're going to see the veins of the brain too. Its scheduled for the 8th of August.

If i live to see the results, i'll tell you what they see.

If i not update my status after 8th of August, then assume i'm death.

Best regards.

 

[Endopharm]

Hi all, specially @Endopharm which recommended me to do this,

I booked an MRI with angiography, which basically means that they're going to see the veins of the brain too. Its scheduled for the 8th of August.

If i live to see the results, i'll tell you what they see.

If i not update my status after 8th of August, then assume i'm death.

Best regards.

Solid choice just to make sure dood!

You'll be ok and can't wait to see ya back on the boards chatting!

Also, if you see any abnormalities, ask your Dr. About lions mane. It's a remarkable mushroom/supplement that can help regenerate neurons in the brain and can help a tonne with brain related injuries.

I've had plenty of concussions and after 6 months of lions mane my Dr. Was pretty shocked in the catscan at how well my brain function was recovering

 

[Phobos]

to clarify: e-tard is retard?

A blend of Extacy and Retard, to describe the condition of those that took enough MDMA/pills to negatively affect their cognitive abilities.

 

[BlueBull]

A blend of Extacy and Retard, to describe the condition of those that took enough MDMA/pills to negatively affect their cognitive abilities.

Seeing people's lips move, hearing the noises that they're making perfectly but not understanding a word a of what they're saying or completely misunderstanding it, is such a weird feeling. That, or saying something yourself that makes perfect sense in your head, but then people look at you funny and apparently you've just made some random noises that don't mean anything. I kind of love that state of mind, though it feels very weird and I only like it when among people that I know well

 

[DeathIndustrial88]

I had to go to the ER this morning.

Woke up at 4AM with my insides burning and projectile vomitted 4 times.

This is the 3rd time in 2 weeks that it's happened to me. Has happened to me before on other AD's, but I always tried to pass it off as "side effect".
Indeed nausea from AD's is common but this was accompanied by high internal body temperature, tremors, ataxia, etc...

I took a klonopin and went back to bed for a bit but told my doc about this morning & they made me go to the ER.
Of course by then a lot of the symptoms had subsided. Had to take my whole daily doses of clonazepam to get my hands to stop shaking.
Got an IV shot of Zofran & sent home. Bloodwork was normal.

Could these 3 episodes in 2 weeks be mild episodes of "serotonin syndrome"? I mean, internal burning, confusion & ataxia accompanied it.


Also, there's no proof that low serotonin is what causes depression. So if my serotonin levels are normal & then I get on a steady diet of AD's, couldn't that result in SS?

This AD has a half life of 32 hours. And it's not the only one that's done this to me before.

Either way I am really disillusioned and I'm afraid I'll be told to keep taking it anyway or be looked at as "non-compliant" for not wanting to deal with these side effects.

Why are all these psychiatric drugs so toxic and with vile side effect profiles? At least for me they are. Antipsychotics included.

Should the serotonin theory of depression be abandoned?

The serotonin theory of depression should be discarded as there is no credible evidence to support it according to a recent review

hospitalhealthcare.com

 

[Purple pills]

So many of the scripted meds effect each other , like i mentioned earlier the tramadol and ssri caused me seizures/confusion. it even said on gp screen cant be prescribed together . then get found bleeding from mouth after biting thru tongue, so scared nearly hit paramedic as he tried to help. they were insisting id taken something which apart from the high amount or tram hadn't.
also something similar to symptoms u mentioned from mirtrazapine and opiate, first exacerbates second massively. suprisingly this wasnt a contra on gps screen at time so makes u wonder how many things they fook up in this regard , maybe even 3 meds causing same thing. are u on anything new etc? gabapentine, amitripylene , ssris , maois all dont mix well for example

 

[DeathIndustrial88]

So many of the scripted meds effect each other , like i mentioned earlier the tramadol and ssri caused me seizures/confusion. it even said on gp screen cant be prescribed together . then get found bleeding from mouth after biting thru tongue, so scared nearly hit paramedic as he tried to help. they were insisting id taken something which apart from the high amount or tram hadn't.
also something similar to symptoms u mentioned from mirtrazapine and opiate, first exacerbates second massively. suprisingly this wasnt a contra on gps screen at time so makes u wonder how many things they fook up in this regard , maybe even 3 meds causing same thing. are u on anything new etc? gabapentine, amitripylene , ssris , maois all dont mix well for example

I'm on Buprenorphine, Gabapentin, Clonazepam. Clomipramine, Propranalol & Prazosin.

I'm fine until I try to take the clomipramine, which is new. Same thing happened when I tried Effexor.
Ironically my doc took me off the effexor cause I was having the same issue with it & then goes & puts me on this new one. which does the same thing. lol

I'm fine when on the other meds, but as soon as I try an SSRI/SNRI. I just feel constantly sick & get shaking hands & chattering teeth.

 

[lonelyDude]

ye sounds like something is wacky with your seritonin.

some people just cant take seritonergic compounds.

really seritoninergic compounds dont stop depression they just mask it by making the person more docile and dopy.

think of morphine and pain.

the pain is still there but you dont notice it as much due to the opiate.

I found I was still as depressed when taking ssri's but did not wish to dwell on it as my mind was numb.

depression doesnt even have to be about chemicals in the head it can also be thought patterning or emotions triggered by events in life.

to be honest I would not be taking ssri's if I had any of those problems when taking them.

if your right and it is mild serotonin syndrom the more you do it the worse it will get.

take a record of your mood when your not on them and if its in exceptable parameters I would tell the doc you dont want them.

if its not in execeptable parameters I would be talking about alternatives that are not working on that part of the brain.

but if you keep a diary of your problems on the drugs and your emotional state off them the doctor will more than likely listen

as they have evidence of the situation and can act without as much fear of screwing up.

 

[Purple pills]

yea really not a fan of gabapentine, im sure more ppl are selling it than taking their scripts, lot of kids buy it etc. my effects from that and ssris were similar.
nm the fact it seems to effect kidneys or at least makes u pee all night, and addictive, stopping it compares to opiate wd imo.
Also prazosin gives many of the side effects u exp before AnE, again who knows which meds or combos exacerbate the side effects , the gps sure dont hey.
effexor causes cramps etc too as you prob know.
check out that program how to change your mind on netflix, lot of theorys on microdosing or one off lsd trips massively changing ppls way of life suffering depression or ptsd. Even mdma as covered in some other threads. it def works short term but obv cant say the long term benefits (i'll let you know if i end up in street naked with a sock as someone put it : ) ) . doubtfully worse than what youre going thru.
be interested to hear if u find the cause . gl