- Jun 28, 2021
Is it safe to take hydroxyzine with methadone? My doctor prescribed it but ever since I got off the hard shit, I have an irrational fear of dying from pills.
Hydroxyzine definitely potentiates opioids but most notably rectally(plugging). Realistically all anti-histamines do but I believe without actually looking it up hyrdoxyzine is on the weaker side?You said it best, your fear is irrational. Street drugs are more risky and cut. With a quick search I was able to find this.
"Opioids, sedatives, and alcohol can make hydroxyzine side effects more intense. These include drowsiness and confusion. Hydroxyzine also interacts with amiodarone, antipsychotics, and some antibiotics. These medications may raise the risk of serious heart rhythm changes."
Looks like you should be fine as it is an allergy medication and has no recreational value. I can't imagine you would be taking more of the Hydroxyzine than prescribed.
That, in UK terms, would be considered a reasonably large dose. At such levels we would likely consider having someone ECG tested to ensure long-QT wasn't an issue. But splitting the dose is absolutely the best way to minimize that risk. It's not methadone itself that is cardiotoxic but one of it's metabolites (specifically dinormethadone). People do metabolize methadone at different rates and in different ways. It's far from perfect but it's been in use for decades so specialists have a lot of experience.
By dinormethadone I assume you mean mixed stereoisomers (Dextro and Levo) normethadone?