This one is a bit like the dissociative version of bungee jumping at high doses. It seems physically safe but holy shit, have a solid trip sitter that has done dissos before
Over all it has helped me, it has made me confront my own mortality and shown me what I want to do in life. I would just highly suggest a trip sitter if you take high doses.
up to 50mg seems rather comfortable quite MXE like
higher doses (for instance 86mg at once first dose) The "hole" is often terrifying, apocalypse, trips through hell type stuff. Also, mobile so please have a trip sitter if you plan on going deep into this one.
I have tried high doses several times in the 70-86mg range and taken approx 150mg-165mg maximum in a night (stepping up to "desired" state) and reaching MXiPr's hole state has generally been a very scary experience. After the peak subsides it has this divine mystical quality though. Could just be my current frame of mind and I have been abstinent from dissociatives for about a year. My tolerance is impossible to really gauge right now I suppose.
Over all, it is certainly worth a try. I have been through many high dose dissociative experiences and this one has truly scared the shit out of me. It has helped me confront my own mortality and left me wanting more however, so it is odd. I reiterate, have a (preferably experienced, sober trip buddy) going deep.
Not for the new or faint of heart.