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Tryptamines The Big & Dandy Bufotenine (5-HO-DMT) Thread - The Truth is Out There


5-OH-DMT suspended in Acetone. Add some Lye... What do you think happens? bk-DMT HCl maybe?

No, I already told you a group isn't removed / displaced or converted so easily. You can't just cut and paste the ketone function out of acetone onto DMT, that is not how chemistry works.
Sorry but I don't feel like explaining all this stuff to you if you can't be bothered to learn introduction to chemistry first. What would be the point? Until then: no, just no.

NBOMe tryptamines have been made apparently, it doesn't seem they were that good on paper. Do a BL google search on that and you will probably end up somewhere in the ADD / NSP forum.

Slap a mescaline onto something? :?

Toad venom IIRC isn't the obvious source for bufotenine, better to get it out of the proper seeds (Vilca? IDK right now). I think toad venom contains 5-MeO-DMT and a lot of other gunk. What is your aim really? Asking questions from a semi-automatic?
better to get it out of the proper seeds (Vilca? IDK right now). I think toad venom contains 5-MeO-DMT and a lot of other gunk. What is your aim really? Asking questions from a semi-automatic?

Vilca/cebil/yopo contains an absolutely ridiculous amount of bufotenine. I think I've seen up to 12% of the weight of the seed is bufotenine. And they are so cheap. It is a great plant for one to learn the skills of extracting and purifying alkaloids...not to mention salting and basing alkaloids. What a fun and fruitful hobby. And the fact that bufotenine has such unique properties that only certain forms of it will be psychedelic means you have to learn a little bit about the BBB too. Great educational tool. And yeah, the trip from them is astounding.
Four seeds were prepared with baking soda; the effects were incredibly powerful visually. There was almost no nausea as well, which I found to be odd (probably because of cannabis). The pain in the nostrils was horrid but it was forgotten about after 15min. It took about that long for visuals to begin. It was like the entire field of vision had an infinitely large constantly changing multicolored pattern superimposed over it. Upon closing the eyes, the pattern was the exact same. There was little distortion of objects mainly just patterning that wasn't derived from pre-existing patterns on the surfaces, as the pattern was sort of superimposed over everything. Upon trying to stand up extreme pain was felt in the feet when pressure was put on them, enough so that it was given up upon. There was also a random pinching pain in the left calve. The experience was over completely after an hour; the effects on the onset and comedown were abrupt in appearing and disappearing.The other day he same snuff was prepared but instead pulled with 91% isopropyl alcohol 4 times and evaporated to yield a flaky/kind of oily/semi-crystalline solid. Results will be posted in due time.
It almost makes me angry how the people that extracted didn't use the redbaron's tek posted here.

iv got some seeds coming my way but they're just 25 seeds of cebil and not 100 grams, how can I modify this tek to use it. walk me through the quantities, will post results

"RebBaron's Yopo Extraction

Here’s what’s needed:

* Acetone: available at most hardware stores. This solvent is actually present in the human body in small amounts. It’s best to use distilled acetone that you distilled yourself if you’re at all worried about contaminants. KleanStrip acetone is pure acetone and 100.0 % volatile according to their MSDS, so there will be no residue left behind after evaporating it. SWIM uses this brand, always distills it, and never finds any left over residue. It seems to be very clean.

* Pickling Lime: available at some grocery stores. It’s used to make pickles crispier. It’s not as poisonous or dangerous as the sodium hydroxide commonly used to extract DMT. Pickling lime is edible but only if greatly diluted.

* Citric acid: available as “sour salt” in some grocery stores. It’s often used in canning. It’s available from many health food or vitamin shops. This is found naturally in fruit.

* Filtering system: coffee filters aren’t that good but will work. For best filtering results it’s better to use a lab filtering system (glass micro-fiber filters, a vacuum pump, and a filtering flask, Buchner funnel, etc.)

Here's the extraction steps:

1) Prepare citric acid solution by adding 1 gram of citric acid to 10 ml of acetone. We’ll use it later so put this aside, go onto step 2, but mix the citric acid solution occasionally. It will eventually all dissolve after about an hour or so.

2) Mix 100 grams of crushed Anadenanthera seeds (either peregrina or colubrina works) with and equal volume of pickling lime (calcium hydroxide) and add enough water to form a paste. Let it sit for about 1 hour, mixing it a few times. Dry it completely in an oven at 150 F.

3) Break apart the dried materal. Add 500 ml of acetone. Mix for about 5 minutes. Let the dry material settle to the bottom. The acetone should be reddish amber in color. Pour the acetone through a good quality filter.

4) Add 10 ml of citric acid solution (from step 1) to the filtered acetone and mix. Tiny crystals will form which look like yellow dust. Let the crystals settle to the bottom. Poor off the acetone, being careful not to pour off the crystals. Discard the acetone. Wash the crystals by adding 100 ml of fresh acetone, mix, let the crystals settle, and then carefully pour off the acetone and discard it (EDIT: you might want to let the acetone evaporate down to about 50 ml before discarding, as more precipitates might form. Keep in mind that a small amount of the alkaloids won’t precipitate out of the acetone. A small portion of this contains the tiny amount of DMT present in the seeds. If you save the acetone, you could extract the last bit of alkaloids using an A/B extraction, but It’s not really worth the trouble). Let all the acetone evaporate off the crystals. They’ll start absorbing water from the air and become dark brown goo once all the acetone has evaporated.

5) Mix the crystal goo with an equal volume of pickling lime. Add enough water to form a thin watery paste. Let it sit for about 1 hour while mixing a few times. Dry in an oven at 150 F.

6) Break apart the dried material. Dissolve in 100 ml acetone for about 5 minutes, mixing a few times. Filter off the pickling time. Evaporate the acetone leaving behind 5-HO-DMT freebase as a single solid mass of amber micro-crystals (and a few other active freebase alkaloids). It looks like amber candy, not crystals. It’s very difficult to form large crystals, so don’t bother. Just scrape it up and store in an air tight container away from light.

You can repeat steps 3-6 with the same seed mix up to 4 more times to recover nearly all the alkaloids if you like, but since the seeds are so cheap, it’s probably not worth the effort."
Hi, my fish has tried a couple of freebase extractions with Anadenanthera Peregrina. The first one left my fish with a powder which was kept and tried later (having a one large hit and holding it from a pipe with direct flame) . The experience did not feel toxic at all but rather had a heavy sort of nice euphoric feeling to it, and would make my fish want to sit down. This would subside within about 10 minutes and my fish was always quite drunk when trying the powder.

My fishes second extraction seemed to go a little better. She sampled the powder having 2 large hits from a pipe with direct flame (maybe only 4 beers this time). The first one she held in and the second one she blew out quite quick out of fear of having too much. This caused a 'spiky' feeling on the back of her head for around 20 seconds. Two of my fishes mates also tried it. Her friends only had one hit and found their muscles felt weak/relaxed/tingly. All three felt something else as well, which was quite strange, and all three decided to go outside for a smoke and felt like sitting down. My fish wonders if she had, had more hits she may have started tripping as if on DMT. The substance seemed to lose strength over time(or it may have been to much beer), as trying multiple times a few weeks later, the same heavy eurphoric feeling took the place of the prickly head almost tripping feeling.

My fish has acquired everything needed to do the below extraction, and she will be trying this next. I imagine you have all seen this but I will post it anyway as I think this is the best my fish has found yet. I will post my fishes findings to confirm his report

repeatedsmokedAnadenanthera colubrina(extract)

repeatedsublingualAnadenanthera colubrina(extract)

250 lb

When I was in Brazil I became quite familiar with Anadenanthera colubrina and have used it orally, sublingually, and by vaporizing it. After initially playing around with the powdered beans, I realized I needed to find a way to make an extract from these if I was going to experience their full effects. While in Brazil, I started to do many experimental extractions.

I tried many A/B extractions based on DMT, using naphtha, as the non-polar solvent, and it failed completely. I tried it with xylene, then heptane, and still no results! It turns out that bufotenine, the active chemical in the beans, is too polar for a typical A/B extraction to be of much use. Eventually I tried a more polar A/B extraction based on Jonathan Ott’s A/B extraction technique. It was the first one of several I tried that actually worked.

Here’s what worked. I soaked the powdered beans in isopropyl alcohol (made pH 3 with hydrochloric acid) for 1 day in a flask with a mixing bar constantly mixing the beans. I then filtered out the beans and evaporated most of the alcohol. Then I added 2 parts water. I used dichloromethane as a safer alternative to chloroform to de-fat the seeds. It took 10 de-fats! It was horribly inefficient and would form emulsions easily if shaken too much. Then I adjusted the pH to 8.5 using ammonia creating free base bufotenine.

Then I extracted free base bufotenine, and quite a bit of other stuff, into dichloromethane (instead of chloroform). It took 10 extractions to get all the free base bufotenine. Again, very inefficient. After evaporating the dichloromethane, I had an amber waxy oily substance that I could easily vaporize. It smelled like peanut oil. To my disappointment, I found the extract not that strong. It took 25 mg to equal a 10 mg dose of free base bufotenine. I did skip the re-crystallization steps done by Ott, so my extract was not pure free base bufotenine. I hate doing re-crystallization, it is so time consuming.

Not being at all satisfied with Jonathan Ott’s technique I played around with the free base bufotenine extract to find out which solvents it was soluble in, in hopes of finding a better extraction technique. I found free base bufotenine was soluble in water, acetone, isopropyl alcohol, dichloromethane, methyl ethyl ketone, and not soluble in xylene, naphtha and heptane. At pH 8-9 it was less soluble in water and more soluble in dichloromethane, however at a higher or lower pH, it was much more soluble in water! This made a typical A/B extraction inefficient because even at pH 8.5, free base bufotenine was still somewhat soluble in water!

So I played around quite a bit and finally invented my own very extraction technique. Here’s how it’s done. Boil the powdered beans in water made pH 3 with hydrochloric acid for about an hour, and then filter out the beans, and repeat 2 more times with new water, also made pH 3 with hydrochloric acid. Concentrate the combined water extracts down and evaporate to leave some solid brownish gunk. Weigh this gunk and measure out an equal portion of calcium hydroxide (the same pickling lime used to make Yopo and Vilca snuff!).

Dissolve the gunk in a small amount of isopropyl alcohol, just enough to make it a thick syrupy liquid, then add an equal portion of water, then mix in the calcium hydroxide. Mix it very well. You don’t want any clumps. It should be the consistency of thick pea soup. Let it sit for about 6 hours for the calcium hydroxide to react with the bufotenine, creating the basic salt calcium bufotenate. Now evaporate it (you can use an oven at 300 F for this step). Once it’s evaporated completely add a generous portion of acetone. Mix it well. The acetone won’t dissolve any of the calcium hydroxide, or much else, but will easily dissolve the calcium bufotenate. Let it sit an hour or more for the non-soluble particles to sink to the bottom, once the acetone takes on a clear dark amber color, poor your mix through a filter to obtain the acetone.

You can repeat the acetone extraction with new acetone a few more times until its clear. Evaporate the combined acetone to get an extremely potent extract that is nearly 90% pure calcium bufotenine, which is one of the most potent forms of bufotenine. It’s the form found in properly make Yopo and Vilca snuff that has been used for thousands of years in South America. It’s more psychoactive than free-base bufotenine and much more psychoactive than the acidic salt form found in the unprocessed beans.

When I first tested the extract in Brazil I didn’t know it was nearly 90% pure bufotenine. I assumed it was maybe 30% bufotenine. Sitting at my desk, I measured 15 mg of the extract weighed using an accurate digital scale. I placed it in the bottom of a glass test tube. I put a 2-hole rubber stopper into the top of the test tube. I attached a rubber hose to one hole, and then I attached a long glass tube to the other whole. The glass tube extended down into the bottom of test tube to allow fresh air into the test tube near the extract. The rubber tube was placed in my mouth. I lit a candle. I placed the bottom of the test tube directly over the candle flame, but not touching it. This way the candle flame was directly under the glass in the test tube were the extract was sitting.

Within 20 seconds the extract started to boil and began vaporizing. With the rubber tube in my mouth I began to slowly inhale the vapor. The vapor was hot but easy on the lungs. I inhaled all of the vapor with one long slow inhalation. I held the vapor in my lungs for 30 seconds. Before exhaling, the effect began. After exhaling, I put the test tube back on its rack and I blew out the candle. Initially there was a bit of a hot tingling felt in the back of my head, then an uneasy feeling in the stomach was felt. Within 30 seconds intense visual effects were noticed. The visuals were getting stronger by the second. After about 1 minute the uneasy feeling in the stomach was completely gone. The tingling in the back of the head moved to the front part of my head and became much more pleasant.

After about 2 minutes into it I started sweating. I felt a little bit nervous but mentally focused. The visual effects were extremely intense. Everything around me appeared to be swirling. The opened eyed visuals were seen in 3-dimensions, something I’ve never experienced, even from high doses of DMT. They were morphing and twisting all around me. I felt quite sweaty, so I looked at my arm to see if there was much sweat. I could not see any actual sweat. My skin looked normal, but there were swirling patterns all over my arm. The hairs on my arm were bending and twisting like little snakes. Everything in the room was swirling.

After about 5 minutes the sweating stopped, and I felt much more relaxed. The visuals were still extremely intense. I could also hear faint voices and sounds from all around that weren’t actually there. I decided to close my eyes, I suddenly started seeing all sorts of fantastic complex morphing shapes pulsating and changing all at a really intense speed. They were more intense and faster moving that previous experiences with DMT. I could hear unusual hypnotic rhythmic sounds playing in my mind. My body disappeared and I was floating engulfed in the most amazing visual experience I had ever had. Colorful neon lights were zooming past me. Fantastic 3-dimensional shape shifting objects were dancing all around me. I felt like I was traveling through a sea of visual data. Everything was pulsating and moving at an incredible speed. This continued for a good ten minutes.

At this point I became aware of my body again. I could feel the tingling sensation all over my body. It was a little alarming. I wasn’t sure what to make of it. My pulse was fine, my breathing was fine, I felt completely relaxed and mentally very clear, so I decided to ignore the tingling sensation. It was actually quite pleasurable. I got up out of my chair and walked around a bit. It was a little tricky to walk. I felt a little twitchy. My movements were a little bit jerky. Everything looked as if it was made of liquid. I saw patterns all over the walls and furniture. If I gazed at anything for a few moments, 3-dimenional images of faces would appear superimposed on the objects around me. This lasted for about 1 hour and slowly faded until after about 2 hours when the effects were completely gone.

After playing around with the acetone extract, I found vaporizing 10 mg to be a very good visual experience. Vaporizing 2 mg was enough to experience the first level of visuals, which were mostly a shimmering effect. Vaporizing 5 mg was enough to have true visuals seeing 2-dimensional patterns. Vaporizing 10 mg was enough to produce 3-dimensional visuals as well as closed eyed visuals. Vaporizing 15 mg is a little too intense and causes a short-lived speedy feeling that makes me feel a little sweaty for the first few minuets. To date I’ve not intentionally gone past 15 mg. For me 15 mg is enough to have intense out of body experiences more intense than anything I’ve experienced from DMT, LSD, psilocybin, ayahuasca, mescaline, or LSA.

I’ve read other reports of people getting nausea and vomiting from Anadenanthera colubrina beans. This is most likely do to the acid salt forms of bufotenine. The bufotenine in the beans needs to either be converted to free base bufotenine or calcium bufotenate or the effects are not as enjoyable. I experimented with different forms of bufotenine. I found the most unpleasant forms were acid salt forms and the most pleasant form was the calcium based basic salt form of it. For example, bufotenine hydrochloride can be made my dissolving calcium bufotenate (a basic salt form) in dilute hydrochloric acid.

In one test I took 10 mg of calcium bufotenate, a very strong visual dose for this form, and I converted it to bufotenine hydrochloride inside a test tube. After the liquid evaporated, I vaporized it. The effects are dramatically different. 10 mg of this acidic salt form produces very slight visual shimmering, no actual shapes or patterns are seen, I feel pressure in the head and body, and unpleasant nausea is felt for 2 hours straight! However, there is more euphoria felt. The pressure and nausea ruin the experience.

I also tried vaporizing 5 mg of bufotenine hydrochloride along with equal portions of calcium bufotenate. The effects are very synergistic. Producing an LSD like experience, without the unpleasant mental effects of LSD. At this dose of bufotenine hydrochloride there is not much nausea felt, mostly euphoria and a pleasant excited feeling felt in the body with improved sense of touch.

I also played around with free base bufotenine. This is more psychoactive than the acidic salt versions, and almost like calcium bufotenate, but not quite as visual, and produces a little nausea sometimes. I found that calcium bufotenate produces the strongest visuals and the least nausea of them all, if any. However, not as much euphoria is felt.

When calcium bufotenate is vaporized, even at high doses, at most I might feel a little uneasy in the stomach for about 1 minute. That’s it. The remaining 2 hours are purely enjoyable. I’ve never felt actual nausea from vaporizing calcium bufotenate. I’ve also used it sublingually. Sublingually the effect is more like psilocybin or LSD, with a deeper psychedelic experience that is not as visual as when vaporized. Again, I’ve not felt any actual nausea from using it this way.

Bufotenine is rather stable, even samples of snuff several thousand years old still contain quite a bit of bufotenine in them. When I came back to the US, I had left some calcium bufotenate sitting on my desk in the open air back in the humid hot Brazilian summer climate for many months. When I returned to Brazil, the calcium bufotenate had become a sticky goo, but when I tested it I found no noticeable loss of potency.

I’ve had an accidental over dose once from old left over bufotenine melting and then vaporizing along with my newly added bufotenine causing me to experience a trip equivalent to approximately 30 mg of bufotenine. For the first three minutes my stomach felt very uneasy, on the verge of feeling nausea, and I felt very nervous and sweaty, I was pacing back and forth and couldn’t enjoy it much. After about 3 minutes into it these bad effects started to fade, at the peak I had a long out of body experience, after that I had a hard time walking around. I kept forgetting what I was doing, my bodily movements were very clumsy. The effects from such a large dose lasted about least 3 hours. At such a dose, visual effects are longer lasting but not any more intense than a 15 mg dose, however annoying side effects start to really kick in.

All in all, I found calcium bufotinate, extracted from Anandenanthera colubrina, to be one of the best psychedelics. It doesn’t have the unpleasant mental effects of LSD. It doesn’t last as long as LSD, mescaline, psilocybin, or ayahuasca, so it’s easier to integrate into a busy lifestyle. It’s neither a stimulant nor a sedative, so it doesn't make me stay up all night like LSD, mescaline, or psilocybin, and it doesn't make me drowsy or mentally clouded like LSA. If fact I feel completely normal and clear headed. I can easily sleep during the effects if I like. I’ve done this and had amazing dreams from it. Or I can easily do something that takes an alert mind.

The only other psychedelic I know of that has some of the qualities of calcium bufotinate is vaporized DMT. Vaporized DMT is nice, but it doesn’t last long enough. As soon as I start to enjoy it, it’s beginning to fade away. Vaporized calcium bufotinate does have more tingling effects than DMT, the visual effects are a little different, but these are not negatives. The tingling felt in the body is quite pleasant after a few minutes. The onset of the effects is much slower, which allows me more time to get comfortable with the experience. And of course it lasts much longer so I have time to really enjoy it. I find DMT is more dreamy in its visual effects, producing softer smoother looking visual effects, while calcium bufotinate produces sharper more defined patterns that are more rapidly changing. Both produce colorful visions. The visual effects of calcium bufotinate are a little more chaotic. But both DMT and calcium bufotinate can bring me to the same place, with only minor differences. When I combine calcium bufotinate with peganum harmala, the effects are stronger and more DMT-like producing very dreamy, more meaningful visual effects. However, I find this combination a little bit sedating.
Very nice! I never cared very much to try yopo (or paricá, as we call it here), but this sound very good!
Will definetly try it!
Nice write up!!

I once tried to do an extraction on those seeds, like you said trying to do it like DMT and not getting much out. But what little bit I did get out I remember smoking and getting really unique effects and amazing visuals when combined with DMT. I also remember it giving me this unique depth perception distortion effect like distance of objects were all screwed up.. which is impossible to explain. I remember mixing it with DMT and it made the visuals waay more amazing.
I noticed this in the bufotenin entry of Tihkal:

The are two structural variations of bufotenine that I feel would be interesting to explore. One deals with the ethers of the 5-hydroxyl group. The O-methyl ether is, of course, 5-MeO-DMT. It is mentioned above under the name O-methylbufotenine. What about the very obvious O-ethylbufotenine, 5-EtO-DMT? It had once been synthesized from 5-ethoxytryptophol in a physostigmine study, and had been converted to bufotenine with aluminum chloride. If the analogy from the phenethylamines applies here (MEM is as potent as TMA-2) then 5-EtO-DMT should be as potent as 5-MeO-DMT. And probably would have to be smoked for the very same reasons. Another variation deals with possible esters on that 5-hydroxyl group. Finding activity in things like the bisulfate bufoviridine would be unlikely, but perhaps an acetate ester (easily made from bufotenine and acetic anhydride) would allow it to make it into the CNS, in a manner similar to the acetate of the 4-hydroxy analogue, psilocin.

Hmm... someone should try to convert it to 5-AcO-DMT and see if it works better :).
I've been reading erowid reports.. there is a bufotenin section, and also a section with a ton of reports of people smoking or snorting the seeds/snuff. Apparently it doesn't even burn that bad. Sounds worth a try without even doing an extraction.


I also typed a report years ago, and found at least 2 other reports where people also described the distortion in size I experienced years ago that was really weird/unique.


Another interesting common visual effect I keep reading about is the loss of detail in objects, like a cell phone will have no buttons, peoples faces don't have a mouth/eyes/nose, everything looks like its made of a solid block etc. I wonder if these effects happen more because the molecule is closer to serotonin than most other psychedelics? The level of WEIRD seems similar or more intense than what DMT does!
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I posted a report on here earlier:

Here's a quick update on smoked/vaporized 5-HO-DMT / bufotenin: SUCCESS

So, I took the advice of a forum poster and took the same extracted bufotenin that I had been failing at with vaporization and changified it.
See: http://bufotenine.weebly.com/bufo-changa.html

The bufotenin was dissolved in solution with extracted Peganum harmala alkaloids, added to a mixture of dried plant matter, and evaporated.

The result was a harsh but effective smoke, every bit as active as the whole alkaloid extraction over catnip that I had attempted a decade or so ago. Gone are the unpleasant somatic symptoms and weak, yellow-tinged OEV- visual effects. Instead, I get a feeling of chest pressure, face and neck tingles, flushing, and a sense of impending nausea that never materializes provided that I sit still. These subside in about four minutes, replaced by ostentatiously detailed, 3D open-eyed hallucinations. Common themes are irridescent yellow curtains drifting in an invisible breeze, brightly colored vortices, and portals in the walls of the room. These are remarkably persistent, staying constant as I get up and move around. They do not form if there is to great a distance between my eyes and my focal point, though.

Closed eye visuals vary. Sometimes, I get black and red geometric shapes strobing at such a rapid speed that it makes me quite motion sick. At other times, I get fully realized, occasionally intimidating inner worlds ala n,n-DMT. Really, the experience is quite similar to DMT minus the mental component of the psychedelic experience. I do occasionally experience audio hallucinations towards the end of the experience, usually in the form of a vaguely menacing deep, male voice.

My current ratio of bufotenin to harmala alkaloids leaves something to be desired. At present, the peak does not seem like it is substantially extended beyond 5-10 minutes by their presence, but the tail of the experience drags on for about an hour. As there is nothing really going on mentally during this time, it's more of a bother than anything. I occasionally get a bit of nausea towards the end, which may be related to the presence of harmalas. It's not generally advisable to go mixing them with 5-MeO-trypts regardless. The joy of the experience really is in the peak, while the rest is more debilitating than enjoyable in my opinion. As before, I don't get any insight through this method. I've heard that other ROAs are more insightful, but the reported side effects are such that I'm not interested in exploring them. The chemical has a nicotinic burn to it on mucous membranes already, so I can't even imagine how much it would hurt to take it nasally. I have found it enjoyable to combine with n,n-DMT, but I prefer them separately.

The few people that I have shared this with, unfortunately, still seem to get vasoconstriction, nausea, and other effects rather than the good ones, which is a real bummer.

Anyway, I hope this contributes to the confusion surrounding 5-HO-DMT's activity. For whatever reason, it seems that the key to getting it to work reliably is through either basification and insufflation (yuck) or through using it on enhanced leaf.
This is one I want to try some day. Its similarity to serotonin really interests me and the reports I've read where it was ingested properly suggest very powerful activity.
Funny enough I read through some of my book library that I have had for 35 years and all of them dismiss bufotenine as not worthy. Johnathon Ott in Pharmacotheon was the last place I read it although that book is from the 90's. In Hamilton's Pharmacopeia episode on bufotenine it had an anticlimactic ending (I was psyched too!). Yet we see all kinds of new data, techs and experiements that sound a lot more promising. Interesting times when we have to revisit something that was written off years ago.
from reading the various reports, i bet that not everyone is capable getting really deep with it, at least not without serious body load (which some people don't seem bothered by); also, it seems perhaps the different salts (and the freebase) have different effects, and especially the different ROAs... seemingly moreso than any other tryptamine.

i would love to try the dmt x bufotenin combo (even though dmt scares the piss outta me)
@nepalnt21 Have you tried 5-MeO-DMT? Wondering if DMT scares more pants off of you or less than 5-MeO-DMT.
i've never done 5-ho-dmt, nor 5-meo-dmt [would love to try either] but i've done my fair share of dmt (been years, not sure i've got the gall to revisit after my last adventure)
I have a very sizeable quantity of Anadenatnera peregrina arriving shortly. Multiple consumption methods shall be used - insufflated seeds, smoked seed preparation, bufotenine extract ingested in every which way possible! (intranasal, oral, sublingual, rectal...intrathecal, intracerebral, intrapenile)...

Has anyone here tried a concomitant ingestion of both bufotenine and moclobemide (or any other MAOI, although I choose moclobemide due to its lack of cardiovascular/peripheral NS side-effects)? I am very eager to prolong the notoriously short duration of bufotenine.
I have combined Syrian Rue alkaloids with bufotenin in enhanced leaf. It works quite well. I've heard that taking a RIMA orally or sublingual before smoking extends the duration much more. I seem to remember trying this a long time ago and finding that only the tail end was prolonged, and that it was more annoying than anything. I've never tried insufflation, so can't speak to that.

As to the safety of this, I don't know. I've never had any issues at the unmeasured, smoked doses that I've used, but that's not much data. There are a whole lot of variables to consider.
I have a very sizeable quantity of Anadenatnera peregrina arriving shortly. Multiple consumption methods shall be used - insufflated seeds, smoked seed preparation, bufotenine extract ingested in every which way possible! (intranasal, oral, sublingual, rectal...intrathecal, intracerebral, intrapenile)...

Has anyone here tried a concomitant ingestion of both bufotenine and moclobemide (or any other MAOI, although I choose moclobemide due to its lack of cardiovascular/peripheral NS side-effects)? I am very eager to prolong the notoriously short duration of bufotenine.

This post was made almost a year ago. Do you have an update for us?
One of components(bufotenin)of notorious cane toad from southern parts of U.S.,Mexico....Australia along with 5-Meo DMT excreted from parotidal glands.I am curious is this the same with Bufo Alvarius,which is common in Europe?🤔