- Nov 19, 2016
I've heard a few times that taking cholinergic and glutamatergic nootropics can seriously potentiate classical psychedelics. For those of you who have combined classical psychs with nootropics, what nootropics were you using, for how long, and at what dose? And did it potentiate the classical psych experience any, or not significantly affect it, or even diminish it?
Noopept, phenylpiracetam and in lesser extent pramiracetam cause excruciating glutamatergic headaches with most psychedelics, especially lysergamides. Aforementioned noots potentiated looped thinking and hypomania. I like using them by themselves or in combo with low dose stimulant, they are great for increasing focus, attention, reducing appetite, increasing initiativeness and provide a mild level of stimulation themselves.
CDP-Choline was fine in low doses combined with psychs until it started causing chest pains and other side effects of acetylcholine overexpression so I discontinued it's use entirely.
I prefer lecithin and eggs as a choline source, Centrophenoxine is also really good, but dont take too much of it or it might make you depressed!
My favorites to go with Psychedelics are:
Aniracetam - great music potentiation and slight increase of visual activity, no noticeable side-effects combined with different variety of psychs.
When comboed with a psych, use about 400-800mg, by itself - about 800-1600mg.
Centrophenoxine - adds cold analytical vibe, greatly enhances memory recollection for me, adds minor stimulation and increases initiative function.
When comboed with psych, use about 100-200mg, by itself - about 200-400mg.
Oxiracetam - very nice and sparkly addition to psychedelic adventures. A much better version of Piracetam (which becomes obsolete when you have Oxiracetam) - increases memory recollection, pattern recognition, visual effects. Not by a huge margin but noticeable enough. No noticeable side-effects combined with different variety of psychs.
When comboed with a psych, use about 500-1000mg, by itself - about 800-1600mg.
Agmatine Sulphate - not really a nootropic as far as the molecular structure goes but it is very nice and interesting substance acting in many ways: as a natural neurotransmitter on it's own, NO - promoting vasodilator, weak NMDA antagonist and imidazoline receptor agonist (MDMA also posses good affinity for imidazoline receptor for example). Goes nicely with pretty much everything. Increases general effects slightly, "smoothes" things over.
Pretty much always take about 500mg of it, sometimes more, sometimes less.
Magnesium - is another notable supplement that is often considered a nootropic. It is a good remedy for body loads, vasoconstriction, cramps and such things. Make sure to use the bioavailable form of citrate, glycinate or similar, not the oxide one - this one most likely will just work as a mild laxative. :D
I should mention that certain psychedelics, such as DMT for example, do not really go with nootropics at all - it becomes too weird, too complicated, hard to bear with experience. It also might happen with any other psychedelic, there are just too many variables at play.
- Does Gingko Biloba also trigger dysphoria in you ? I will now avoid products with it, because the trade-off is way off for me
Yes it certainly does to me. It also makes me feel cold and robotic. I dont use it for that particular reason too.
- Did anyone realize a positive effect from consuming choline-derivates (CDP-choline for instance) ? I got the feeling, that it is all placebo. I rather eat a lot of eggs rather than buying expensive placebo (?) supplements
Plenty of effects, in fact, too much in my taste - it easily can cause acetylcholine overexpression symptoms, such as chest pains, tightness, muscle cramping, eye ticking. I prefer Lecithin, eggs and occasional Centrophenoxine as a source of choline.
- How high do you guys rank Huperzine, I guess it is essential in a stack ?
I use it pretty much exclusively when I go to sleep to have more dreams and to wake up more refreshed with less hours. It has numerous interactions and you gotta be very careful on redosing as it seems to last quite long. I like experimenting with it though and it's high potency definitely allures me
I suppose I would just want to extract the good stuff from it (caffeine, theanine, antioxidants?)
I just had a pouch of about 3 oz in the pantry that my ex had left and since I?ve gotten heavily into making kratom extracts I figured I would just give it a shot. I?m not a tea drinker but I like the idea of putting things in convenient little capsules.
So I did end up trying it. Seemed to work out fine. It dried nice and easy; much more so than kratom. I started with a quarter gram and felt nothing. Tried a half gram next day and maybe felt a little something. Today I?ll try a full gram.
While making it I realized it?s probably just the same as this stuff I used to buy at the vitamin shop. Oh well, it was fun, but it?s so inexpensive to buy in capsule form that if I ever want it again I won?t bother to put all that effort into making it.
I know very little about nootropics, just recently started hearing the word but I?m very curious.
A lot easier to just purchase a green tea extract or matcha tea extract - different standardized extracts out there that are pretty cheap and very effective. Fun to work with powders yourself though, I totally get it!