The pathogenesis of ketamine cystitis (KC) has been recently linked with immune response to patients but the same has not yet been established. Hence, this study aims to propose a possible immune mechanism of irreversible bladder damage caused by KC. A total of 53 KC patients and 21 healthy...pubmed.ncbi.nlm.nih.gov
I cited the study to show it damages rat bladders. It was the bulk of my disso use and it damaged my bladder. An above poster also blamed MXE for bladder dysfunction. MXE amd ketamine are similar in pharmacology. People can come to their own conclusions from these pieces of information.If you think the rat studies with MXE had no relevance to human pharmacology, you can't cite the results to say it's urotoxic in humans.
Also, you must either be predisposed to bladder damage on the basis that I had access to an endless amount of free MXE, courtesy of vendor I was helping (and god did I hammer it), yet really it took really really heavy ketamine use to give me a dose of bladder pain. I'd think 2-FDCK could be bad for bladder damage, as it requires doses similar to ket and lasts about as long (makes me think halogen groups at the 2 position, along with a keto group on the cyclohexyl ring are the most likely to cause damage.
I don't know if what youre implying is that the milligram dosage amount or the chemicals structure of a drug itself is what is responsible but I keep hearing people say that.
I think it's purely based on pharmacogical effect which results in immunological cascades downstream that cause the disease. This mechanism is discussed in the paper incited earlier and I have requoted above.
The structure doesn't matter. The milligram amounts put into the body being less because 3meoPCP is more potent than K doesn't matter. It's the extent of immunological response caused by the drug.
Plenty of science on non drug induced interstitial cystitis suggests similar immune based mechanisms of cystitis. Here's a paper connecting the immunological etiology of the disease and ketamines pharmacology facilitating these immune cascades. Good luck explaining that ketamine analogues like mxe don't do the same thing while having very similar targets and pharmacology, just different structures and far higher potency...knowing that it damages rat bladders and knowing there are reports of users developing the same issues as ketamine.
What is so different about mxes pharmacology from ketamine that would make you think it doesn't do the same thing ketamine does discussed in the above cited Paper?
What I see people saying is almost akin to saying that fentanyl is less likely to overdose someone because you take less milligrams of it than heroin.
Us addicts will tell ourselves anything to convince ourselves a drug is safe.