Just want to say, in response to the paper at the start, claiming to have induced bladder damage in rats; take a look at the mg/kg dose that it took. The equivalent dose in humans would have people in a state of surgical anaesthesia 22 hours a day. Given enough, anything is toxic (salt, sucrose, even water & oxygen). What is important is the 'theraputic ratio (effective dose : toxic dose). With methoxetamine, it has a far better theraputic ratio than ketamine (which was one of the targets in its design).
So, not saying it won't damage your bladder, just you'll need someone to give it to you, as you're effectively dead, 22 hours a day. Strange that, seeing the widespread use of it, there have been no recorded incidents of bladder damage, in humans, since its creation.
The defence rests...