Opioids Citalopram and codeine

[Survival0200]

I've noticed, that I won't get as much euphoria from codeine as before. I think the culprit might be citalopram, which I'm taking 40 mg a day, and it's a weak CYP2D6 inhibitor.

Before, I used to get nice feelings from codeine for a few hours from as small dose as 100 mg. Today, if I take 200 mg, I get mild euphoria, which lasts an hour.

So, I was wondering if others taking citalopram have noticed the same thing happening?

 

[Survival0200]

Any thoughts about this?

 

[Snafu in the Void]

SSRIs blunt a lot of drugs, including opioids

"Stanford researchers found that SSRIs reduce the effectiveness of hydrocodone and codeine"

Common opioids less effective for patients on SSRI antidepressants

Patients taking antidepressants known as selective serotonin reuptake inhibitors do not respond well to hydrocodone, such as Vicodin, Stanford researchers report.

med.stanford.edu