• Psychedelic Drugs Welcome Guest
    View threads about
    Posting RulesBluelight Rules
    PD's Best Threads Index
    Social ThreadSupport Bluelight
    Psychedelic Beginner's FAQ
  • PD Moderators: Esperighanto | JackARoe |

MXE LSD Cross-Tolerance

I can promise you one thing - it is ABSOLUTELY NOT going to dampen the experience in any way. Every time I've ever take LSD and MXE together, it made the acid seem way trippier, WAY more visual - to the point of being overpowering and having to sit the fuck down, and it always made my doses seem WAY fucking stronger per tab. I usually don't take less than 5 hits if I'm eating acid by myself............when I started using MXE daily - I cut back to 2 doses at a time and they felt like eating fucking 5. The synergy is AMAZING and super fun. I highly recommend this combo. You will NOT be disappointed. I have some Benzo's on hand tho - MXE can make LSD get kind of confusing at times when you least expect it. Also, if you do any MXE while your tripping, cut the dose down by 20-30%. The acid gives the MXE some xtra kick as well. Enjoy, just be safe. This is an INTENSE combo. Be aware.
 
Mr. Meowfish said:
I can promise you one thing - it is ABSOLUTELY NOT going to dampen the experience in any way. Every time I've ever take LSD and MXE together, it made the acid seem way trippier, WAY more visual - to the point of being overpowering and having to sit the fuck down, and it always made my doses seem WAY fucking stronger per tab. I usually don't take less than 5 hits if I'm eating acid by myself............when I started using MXE daily - I cut back to 2 doses at a time and they felt like eating fucking 5. The synergy is AMAZING and super fun. I highly recommend this combo. You will NOT be disappointed. I have some Benzo's on hand tho - MXE can make LSD get kind of confusing at times when you least expect it. Also, if you do any MXE while your tripping, cut the dose down by 20-30%. The acid gives the MXE some xtra kick as well. Enjoy, just be safe. This is an INTENSE combo. Be aware.
Click to expand...

I might actually try this but I was actually just asking if MXE the day *before* acid would detract from the trip. From what you're saying though it sounds like there is no cross-tolerance
 
There is not at all. MXE has such a long half-life, as soon as you take that LSD the next day - I guarantee it kicks the MXE from the previous day back in to an extent. This always happened to me anyways, but I also used MXE daily quite heavily over a 2+ year period. Could make a difference in the extra effects I got. It made the L WAY more visual for only 2doses. You're gonna have fun, I guarantee.
 
Well there is no tolerance because mxe doesn't effect the same receptors as LSD.

I doubt that it would make much difference to your lsd trip if you took mxe the day before. Maybe you'll get a nice afterglow from the mxe that will put you in a good head state for the lsd but unless you are particularly new to either substance I doubt anything more would happen
 
There is definitely no tolerance.
Mxe and other dissociatives work on NMDA receptors mainly whereas LSD works mainly on serotonin receptors.
In fact using dissociatives and psychedelics together feels AMAZING
But tread lightly, they greatly potentiate the effects of one another and can lead to a very frightening confusing trip if you aren't careful
My fav was 20mg 2c-e and ketamine, made everything I was seeing go into this ridiculous choppy frame by frame vision, simply fantastic
 
hmmm... correct me if im wrong but....

i thought RC dissasociatives work on serotonin receptors too... perhaps not to the same degree or with the same affinity, but i remember reading about serotonin syndrome danger from mxe and mdma combos, and also 3meo pcp is supposedly a serotonin releaser....
 
kingme said:
hmmm... correct me if im wrong but....

i thought RC dissasociatives work on serotonin receptors too... perhaps not to the same degree or with the same affinity, but i remember reading about serotonin syndrome danger from mxe and mdma combos, and also 3meo pcp is supposedly a serotonin releaser....
Click to expand...

I think the difference is MXE is a mild serotonin reuptake inhibitor while LSD is an agonist at specific 5-HT receptors. So no noticeable tolerance effect should be observed (and this is backed up by personal experience using mxe and classic psychedelics)
 
kingme said:
hmmm... correct me if im wrong but....

i thought RC dissasociatives work on serotonin receptors too... perhaps not to the same degree or with the same affinity, but i remember reading about serotonin syndrome danger from mxe and mdma combos, and also 3meo pcp is supposedly a serotonin releaser....
Click to expand...

3-meo-pcp is an inhibitor of the serotonin transporter, not releaser. However LSD is not a serotonin inhibitor or releaser, so there is no problem.
 
thickskin said:
I think the difference is MXE is a mild serotonin reuptake inhibitor while LSD is an agonist at specific 5-HT receptors. So no noticeable tolerance effect should be observed (and this is backed up by personal experience using mxe and classic psychedelics)
Click to expand...

Exactly.

I have to also recommend doing psychedelics with MXE. They synergize perfectly, as long as the dosages aren't too high.
 
You must log in or register to reply here.
Top