Tested yellow Philip Plein in a laboratory.

[Fertile]

Well Wikipedia gives a very good definition.

But put simply, it's the ratio of how soluble a compound is in water to how soluble it is in fat tissue.

So a compound has to have SOME water solubility so that it can be absorbed by the stomach, transported by the blood stream and transported into the. But important to remember that the brain is essentially fatty. That's why all psychoactive compounds have to have a LogP of 0.5-5.

It's worth reading about Lipinski's 'Rule of Five' which shows all the major factors that influence absorption, distribution and redistribution.

But 3.2 is quite high so MDMA is lipophilic.

 

[Mjäll]

Didn't Shulgin say 'not more than 1.5mg per Kg of bodyweight' or similar? Interesting since MDMA has a LogP of 3.2 so most of it will migrate to fat tissue. That a limit is set on bodyweight strongly suggests that it's toxic to the fatty organs of the body.

Are there other ways to set a recommended max dose for a substance?

 

[Fertile]

Study Comparing Three Doses of MDMA Along With Therapy in Veterans With Posttraumatic Stress Disorder - Full Text View - ClinicalTrials.gov

Study Comparing Three Doses of MDMA Along With Therapy in Veterans With Posttraumatic Stress Disorder - Full Text View.

clinicaltrials.gov

Well, in medical settings they seem to go for 125mg i.e. ⅛ gram which is often regarded as the 'classic' dose. Back when it cost £20/pill, they were reliably 120-125mg. 90+