With increasing batches, i've found decreasing mania. The first actual crystalline batches were the ones that turned me into Terence McKenna. Then, my more later tan batch seems so be much more grounding and medicinal. I'm currently on my 4th gram of Meo within a year's span, the white fluff batch which seems to have a peculiar quality.
This white batch seems to have mild anti depressive effects underneath 20-30mg, which is what i'm after. I think a lot of the way this is unfolding is due to tolerance, which is fine because ultimately I was looking for an anti-depressant that actually works. (Coming from a history of Heroin, Crack, MDPV, Phenaz, and a variety of other substances, I'm pretty happy to currently be using Kratom, Alcohol, Weed, and Meo as my medicinal regimen.) Once I get over the 30mg mark, incredibly strong mania ensues. This fourth batch seems to induce something quite undesirable at high doses, whereas my initial chunky crystalline batches produced a remarkably godlike mania at doses above 15mg.
Overall, I haven't experienced any truly detrimental effects other than coming down which can have a slight rebound effect, yet the overall positives seem to very strongly outweigh the negatives since my life is improving on a grand scale in a way I would have never thought possible. I'm able to use psychedelic drugs occasionally once again to connect to my surroundings and have the best experiences imaginable which is what I was after in the first place when dabbling in drugs about 14 years ago.
So, to conclude for now, psychedelics and dissociative drugs have saved my life and 3-meo-pcp has probably been the real turning point. I have about 250mg or so left of the tan flour batch, and have begun crossfading dosing into the white batch. More to come. . .
Side note - The current tan batch seems to be 2x as strong as the white fluff, and has a far more caustic/burning lasting reaction to the tongue (way more bitter). I much prefer the tan to the white batch, which has a strange mildewy trombone-like flavor.