- Feb 8, 2021
The N-methylated benzofurans actually have a similar agonist activity at 5HT2B compared to MDMA. 5-APB and 6-APB on the other hand are very selective and have considerably higher affinities at that receptor.The increased cardiotoxicity caused by 5HT2B agonism doesn't help its case either.
3,4-Methylenedioxy-N-methylamphetamine (MDMA) has been shown to be effective in the treatment of post-traumatic stress disorder (PTSD) in numerous clinical trials. In the present study, we have characterized the neurochemical binding profiles of three MDMA-benzofuran analogues...