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The Big & Dandy 6-APB Thread (Part 5)


Feb 8, 2021
The increased cardiotoxicity caused by 5HT2B agonism doesn't help its case either.
The N-methylated benzofurans actually have a similar agonist activity at 5HT2B compared to MDMA. 5-APB and 6-APB on the other hand are very selective and have considerably higher affinities at that receptor.



Staff member
Sep 7, 2020
The Great White North
Okay, I have posted this in every Big and Dandy and I'm also going to post it here since I just added 6-APB and a few others to the survey.

PLEASE, if you have tried 6-APB, fill out my survey I'm about to describe and link to? And if you get a chance I'd like for you to also fill it out for any other psychedelic you've done. Thanks!


I wanted to take a minute to let everyone know in each of the substance Big and Dandies about the community project of the PD forum which has been being worked on for the past 2 years or so, the Psychedelic Effects Profile survey. This survey asks you a number of questions, starting with the substance taken, the dose, the method of administration, other substances (non-psychedelic) ingested during the trip, and set and setting, and then it goes on to ask about a variety of specific effects, and you can select whether or not you experienced them and if so, the intensity level of that effect on a 5-point scale.

Thank you for your help with this! For this to be of any use whatsoever, we need as many responses as we can possibly get, so please take it as many times as you have time for, for as many substances as you have had proper trips on. We want to gather the full range of effects possible so feel free to take it for positive as well as negative experiences, for earth-shattering and average. Each time taking the survey is for a single trip on a single substance - no combinations please, as it taints the data for each substance. In the future I may make another survey for combinations. The survey takes about 5 minutes to get through so it's not too much of your time.

(You can report on combinations, just not combinations with other psychedelics)

For further discussion of this project, please see the stickied thread at the top of the forum that starts with "Community Project". To take the survey, please click on this link: http://freeonlinesurveys.com/rendersurvey.asp?sid=hvw6fx9mmvzz82l599169

Were the 6-APB results ever posted?


Staff member
Feb 8, 2006
In the mountains
No, they weren't, unfortunately. Not enough participation, and I also rethought the design of the survey partway through. I never ended up posting any results. That's why I was excited about your idea though. I still am, it's just a question of time and energy.


Jul 13, 2022
I though because 4-fa is a light releaser of serotonin and mostly dopamine that I'd be fine, but apparently amphetamine the days coming up to a roll can make it very weak. Guessing this is the case with 4-fa due to the chemical similarity. techzpod download mobdro
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