Tihkal entry for MIPT said:EXTENSIONS AND COMMENTARY : This is the simplest tryptamine with the somewhat magical pair of nitrogen substituents, a methyl group and an isopropyl group. Why should this combination allow a molecule to be orally active, even though the conventional thinking is that if there is a methyl group there, the amine oxidases will destroy it? My sense is that it is the N-small-group that does the job in the brain, and it is the N-big-group that keeps the inactivating oxidase enzymes away from the nitrogen atom. This is consistent with the N,N-dimethyl compound (DMT) not being orally active. Lying midway between DMT and DIPT is the ethyl compound, N-ethyl-N-methyltryptamine, or MET. It can be made by adding ethyl acetate to a reaction mixture where the formamide of tryptamine (see under NMT) has been reduced to NMT but there is still a goodly excess of hydride still remaining. The free base, as an oil, shows oral activity in the eighty to one hundred milligram range, so going from a methyl to an ethyl does indeed protect the compound from total enzymatic annihilation when taken orally.
Tiapan said:From Erowid report for DET
The best comparison would be to that of a very high dose LSD or Psilocybin experience, entering at the peak immediately, rather than waiting for 2-3hrs. The initial DET effect is far stronger than anything experienced with high LSD doses. The initial effects begin within 30secs increasing in strength at a massive rate reaching peak of maximum effect within 5 minutes The 'non-compus stage' (immobile stage - you really dont feel inclined to move much) this part of DET peak lasts around half an hour gradually weakening in effect to the level of a high LSD peak after about an hour. (One could walk relatively easily again). The effect diminished gradually for a further 2-3hrs, fading back to normality and ending with virtually no indication the experience had occured - very clean finish.
Psychedelics_r_best said:GUYS!.................Damnit. This is just like DMT except it has a methyl and an ethyl group instead of two methyls. You don't need to go slack jawed, googly-eyed, and drooling when you see something a tiny bit different. !
hugo24 said:-If its a salt,it will go into solution before it melts...