Vyvanse not working: questions about trypsin, anti-psych, depression, PAWS, tolerance

[ToastedAlmonds]

Backstory: I was prescribed 40mg Dextroamphetamine IR for ~10 years, circa 2003-2013, and even after daily use the whole time, the meds still never failed to make me euphoric/productive/energetic. During that period of time, I weighed between 70-100lbs (I was anorexic). 2010-2014, I was prescribed large amounts of Oxycodone and Fentanyl Patches which I abused and although I could still feel the energy from the amps, I was too high off the opiates to really do anything with the energy. (I'm a normal weight now, but figure the weight has a lot to do with the effects of the dose- 40mg daily for someone weighing that little is a LOT)

I finally got off the opiates in late-March of this year (2014) and while in detox, I was taken off the Dexedrine. I also started back on Latuda (a newer anti-psychotic) because of amphetamine-induced psychosis.

A few weeks ago, in late-July, I was prescribed 30mg Vyvanse by my psychiatrist to combat the lazy/fuzzy feeling from the Latuda. The first week or so was great, I was euphoric and hyper focused again. However, after that first week, the effects became increasingly less noticeable- I took a double dose a few times (60mg) and the first few times of the increased dose, I felt high-ish again, but definitely not low the first few days. (Yes, I know I shouldn't be upping my Vyvanse dose by myself, so please no lectures!)

Yesterday, my psychiatrist upped my dose to 40mg, but of course I've been taking more-upwards of 100-120mg daily. This morning, about 3 hours ago, I dosed 100mg at once... I know that the Vyvanse has already kicked in, but I only feel awake- not euphoric or energized in the least. Anything below 100mg just leaves me with a tired, spacey feeling. It seems that I just can't get any sort of high back though, regardless of how much I take.... my eyes don't even dilate! (But I guess the Vyvanse is kind of working if I can write such a long post...)

So, I have a bunch of questions:
I know the Latuda can negate the amphetamine's effects, but I was able to get high while taking it several weeks ago, so I'm not sure that the Latuda is the cause of my issues.
-Can anti-psychotics randomly inhibit dopamine? Sometimes allowing me to get high and other times not?
I also know that long-term amp abuse can burn out the dopamine receptors, sometimes permanently. Maybe after a few months off of the Dexedrine, my receptors started repairing themselves only to quickly burn out again after restarting the amps?
-Would taking a few days off the Vyvanse or taking a dopamine precursor like L-Lysine help any?

Long-term opiate abuse causes post-a it withdrawal after cessation which so know effects dopamine production/regulation for up to a year or more.
-Is there any chance I will be able to get high off amps again after 1yr off of opiates?

I also believe that I have clinical depression, I've been treated with various SSRI's since ~1999 on and off, most recently prescribed Prozac beginning in March- it truly worked wonders. However, my psychiatrist stopped the Prozac 2 weeks prior to starting the Vyvanse because we tried Strattera first which she said works as an anti-depressant. She doesn't want add Prozac back in right now since we're still titrating the Vyvanse dose and she wants to eliminate any variables so we can figure out the right Vyvanse dose.
-Can a chemical imbalance caused by depression effect the amp's effects?

I know that Vyvanse depends on trypsin production to activate the D-amp. I have gastroparesis (delayed stomach emptying) so I may have lower levels than normal of digestive enzymes. I always take my Vyvanse with half a protein shake (26g protein) to encourage trypsin production, but haven't really noticed a difference from the times I don't have any protein intake with my meds.
-Would taking a few Pancreatin enzymes with the Vyvanse help? Or possibly dissolving the Vyvanse with a few Pancreatin caps and letting it sit for a while?

-Could simple tolerance be my problem, seeing as I was taking ~1mg+/kg of D-amp before and am now taking ~.15mg/kg, which is less than 1/6 of my previous dose?
-If so, does Vyvanse really have a "ceiling" dose (I've read multiple debates about this)... it's just not feasible for me to take the 600mg of Vyvanse that would give me to equivalent ~1mg/kg dose as before.

Anything else you can think of? I know there's a lot of variables, but I'm wondering which ones are most suspect and if there's any remedy to perhaps solve the issue(s)... Or if it's just totally impossible for me to get high off amps anymore?
Sorry, I know this is long- but thanks in advance for anything you can offer!!!

 

[AlphaMethylPhenyl]

I wouldn't take a dopamine pre-cursor...

If you're trying to get high, I can't really help you. If you're looking for therapeutic effects, please consult your doctor.

Yes, depression can make the amphetamine work less well, or better, depending on the kind of depression.

I wouldn't know if it has a ceiling dose - never took more than prescribed.

 

[Riddleme]

I was previously on 2 x 20 Adderall daily. My Doctor put me on 40mg of Vyvanse daily recently. I can hardly stand the stuff. When the therapeutic window is working on vyvanse, which is about 3-5 hours it actually works better than the adderall. However, It is like signing a contract with the devil lol. After the window has passed, I feel extremely anxious and depressed beyond any type of depression I have ever experienced so I stopped taking it. It does not matter what time of the morning I take it either. Or what I eat. Protein / trypsin etc does not stop the insomnia. I am on 1 mg of xanax to help to sleep at night but it does not touch the insomnia. I like to control my medication. Is there a way to make vyvanse instant release. A simple way? without side effects as mentioned above? I have been perusing the forums and I am new so looking for something that works that does not have the horrible side effects. Any info would be greatly appreciated. No the Dr. will not give me Dex IR. Its Adderall or Vyvanse.

 

[Tdog1776]

ToastedAlmonds, one thing with amps is that tolerance builds fast, so at first it made you feel euphoric, but now your tolerance is up & as u keep increasing your dose, the higher and higher your tolerance will be. If you were to take a break from it for a while, your tolerance will go down. Riddleme, Vyvanse is a pro-drug, meaning it does not start working until your body metabolizes it. You cannot snort it and there's no way to make it instant release, as it is not in active form like Adderall is. Unlike Vyvanse, Adderall can be snorted and taken in other ways other than orally, whereas Vyvanse can only be taken orally for it to work. Hope I was of some help.

 

[Riddleme]

Thank you for the reply, Tdog1776! I have done much research on adderall vs vyvanse these last few months. Seems to me Shire released the vyvanse knowing the therapeutic window lasts the same amount of time as instant release. Tried a recipe on the forums to cleave off the l Lysine from my 40 mg tab. It worked great. Did not feel like I took a medicine. I don't want to feel my meds. I don't want to feel side affects from them either. However, I did sleep great after cleaving off the l lysine molecule but felt like "sickish" this morning, much like adderall side affects. Sigh. I do not know why peeps wanna do this crap recreationally. Also, the brain does not become tolerant to these meds, it merely becomes desensitized. I know weird grey area. I read on here that it is Sorta like you aren't tolerant to the clothes you wear, your brain desensitizes that they are on your body so you don't notice them. Thank you so much for your kind input. I will prolly switch drs.

 

[Riddleme]

Also as a follow up to previous post, and not to spam, I am going to ask for an antagonist from dr so I do not have to escalate my meds.

 

[AlphaMethylPhenyl]

^? a dopamine antagonist might attentuate negative side effects, but it probably won't decrease tolerance.